Recruiting
Phase 1

HSV G207

Sponsor:

M.D. Anderson Cancer Center

Code:

NCT03911388

Conditions

Neoplasms, Brain

Glioblastoma Multiforme

Glioblastoma of Cerebellum

Neoplasms

Astrocytoma

Eligibility Criteria

Sex: All

Age: 3 - 22

Healthy Volunteers: Not accepted

Interventions

G207

Study Details

Brief summary:

This study is a clinical trial to determine the safety of inoculating G207 (an experimental virus therapy) into a recurrent or refractory cerebellar brain tumor. The safety of combining G207 with a single low dose of radiation, designed to enhance virus replication, tumor cell killing, and an anti-tumor immune response, will also be tested.

Funding Source- FDA OOPD

Conditions

Neoplasms, Brain

Glioblastoma Multiforme

Glioblastoma of Cerebellum

Neoplasms

Astrocytoma

Study ID

NCT03911388

Start date

Sep 12, 2019

Status verified date

Aug, 2026

Completion date

Sep 1, 2027

Anticipated

Primary completion date

Sep 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 3 - 22

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥ 36 months and < 22 years
  • Pathologically proven malignant cerebellar brain tumor (including medulloblastoma, glioblastoma multiforme, giant cell glioblastoma, anaplastic astrocytoma, primitive neuroectodermal tumor, ependymoma, atypical teratoid/rhabdoid tumor, germ cell tumor, or other high-grade malignant tumor) which is progressive or recurrent despite standard care including surgery, radiotherapy, and/or chemotherapy. A pathologically proven secondary malignant cerebellar tumor without curative treatment options is eligible.
  • A review of the MRI scan will be necessary to determine if the tumor location and size are such that the patient may be included in the study. The MRI scan must be reviewed and approved by the site neurosurgeon and/or study radiologist for enrollment. The following guidelines must be met: Lesion must be ≤ 3.0 cm in diameter and surgically accessible as determined by MRI. Larger tumors may be surgically debulked and treated if ≤ 3.0 cm after debulking. Tumor measurements should be confirmed on the Immunotherapy Response Assessment in Neuro-Oncology (iRANO) form or the institutional MRI report
  • Patients must have fully recovered from acute treatment-related toxicities of all prior chemotherapy, immunotherapy or radiotherapy prior to the date of G207 administration. All washout intervals below are measured relative to the date of G207 administration.
  • Myelosuppressive chemotherapy: patients must have received their last dose at least 3 weeks prior (or at least 6 weeks if nitrosurea) to G207 administration.
  • Monoclonal antibodies: patient must have received the last dose ≥ 21 days prior to G207 administration
  • Investigational/Biologic agents: patients must have recovered from any acute toxicities potentially related to the agent and received last dose ≥ 7 days prior to G207 administration (this period must be extended beyond the time during which adverse events are known to occur for agents with known adverse events ≥>= 7 days).
  • Viral therapy: Patients must have received viral therapy ≥ 3 months prior to G207 administration and must have recovered from all acute toxicities potentially related to the agent
  • Radiation: Patients must have received their last fraction of craniospinal radiation (>24 Gy) or total body irradiation ≥ 3 months prior to G207 administration. Patients must have received focal radiation to symptomatic metastatic sites or local palliative radiation ≥ 28 days prior to G207 administration.
  • Autologous bone marrow transplant: Patients must be ≥ 3 months since transplant prior to G207 administration.
  • Absolute neutrophil count > 1000/mm3
  • Platelets ≥ 100,000/mm\^3
  • Prothrombin time (PT) or partial thromboplastin time (PTT) ≤ 1.3 x control
  • Creatinine within normal institutional limits OR creatinine clearance >60 mL/min/1.73 m\^2 for patients with creatinine levels above institutional normal
  • Total bilirubin ≤ 1.5 mg/dl
  • Transaminases ≤ 3 times above the upper limits of the institutional norm
  • Patients < 16 years, Modified Lansky performance score ≥ 60; patients ≥ 16 years, Karnofsky performance score ≥ 60
  • Written informed consent in accordance with institutional and Food and Drug Administration (FDA) guidelines must be obtained from patient or legal guardian

Exclusion Criteria:

  • Acute infection, granulocytopenia or medical condition precluding surgery
  • Pregnant or lactating females
  • Diagnosis of encephalitis or central nervous system (CNS) infection ≤ 3 months prior
  • Receiving ongoing treatment for encephalitis, CNS infection or multiple sclerosis
  • Tumor involvement which would require ventricular or brainstem inoculation or would require access through a ventricle in order to deliver treatment
  • Patient requires an escalation in ongoing systemic corticosteroid therapy within 7 days prior to G207 inoculation or requires ongoing systemic corticosteroid therapy at a dose > 2 mg/day of dexamethasone (or equivalent) at the time of inoculation. For this study, 'systemic corticosteroids' include oral, intravenous, or intramuscular formulations. A single, non-consecutive dose does not constitute exclusion. Physiologic corticosteroid replacement therapy (e.g., hydrocortisone for adrenal insufficiency) is not considered immunosuppressive and does not constitute exclusion
  • Known human immunodeficiency virus (HIV) seropositivity
  • Concurrent therapy with any drug active against herpes simplex virus (HSV) (acyclovir, valacyclovir, penciclovir, famciclovir, ganciclovir, foscarnet, cidofovir) or any immunosuppressive drug therapy (except dexamethasone or prednisone)
  • Patients with a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment of the investigational regimen for this trial
  • Concurrent anticancer or investigational drug

Study Design

Enrollment

24 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: HSV G207

Single dose of HSV-1 (G207) infused through catheters into region(s) of tumor. If G207 is safe in the first cohort of patients, subsequent patients will receive a single dose of G207 infused through catheters into region(s) of tumor followed by a 5 Gy dose of radiation to the tumor given with 24 hours of virus inoculation.

Interventions

G207

Single dose of G207 infused through catheters into region(s) of tumor. If G207 is safe in the first cohort of patients, subsequent patients will receive a single dose of G207 infused through catheters into region(s) of tumor followed by a 5 Gy dose of radiation to the tumor (which includes progressive leptomeningeal disease or any site of gross tumor progressing in the brain parenchyma) within 24 hours of virus inoculation.

Primary outcome measure

  • Safety and Tolerability as Measured by Frequency of Grade 3 or Above Adverse Events [ Time Frame: Baseline to 15 years ]

Central Contacts and Locations

Central contacts

Kara Kachurak, CRNP

832-750-5661lkgkachurak@mdanderson.org

Gregory K Friedman, MD

gkfriedman@mdanderson.org

Locations

University of Alabama at Birmingham Cancer Center

Recruiting

Birmingham, Alabama, United States, 35233

Contacts

Laura K Metrock, MD

205-638-9285metrock@uabmc.edu

Principal Investigator:

James Johnston, MD

Siteman Cancer Center at Washington University

Recruiting

St Louis, Missouri, United States, 63110

Contacts

Mohamed Abdelbaki, MD

(314) 454-2002MohamedA@wustl.edu

Principal Investigator:

Mohamed Abdelbaki, MD

MD Anderson Cancer Center

Recruiting

Houston, Texas, United States, 77030

Contacts

Kara Kachurak, CRNP

832-750-5661kgkachurak@mdanderson.org

Gregory Friedman, MD

gkfriedman@mdanderson.org

More Information

Sponsor

M.D. Anderson Cancer Center

Last update posted

Sep 4, 2026

Last verified

Aug, 2026

Keywords

  • Brain Tumor, Recurrent
  • Glioma
  • Glioblastoma Multiforme
  • Gliosarcoma
  • Medulloblastoma
  • Anaplastic Astrocytoma
  • Oligodendroglioma
  • Rhabdoid Tumor
  • Ependymoma
  • Germ Cell Tumor
  • Choroid Plexus Carcinoma
  • Cerebral Primitive Neuroectodermal Tumor
  • Giant Cell Glioblastoma
  • Atypical teratoid/rhabdoid tumor
  • Secondary Malignant Cerebellar Tumor
  • Embryonal Tumor
  • Neoplasms
  • Oncolytic Virus Therapy
  • Virotherapy, Oncolytic
  • Immunotherapy
  • Central Nervous System Agents
  • Antineoplastic Agents
  • Pediatric
  • Pediatrics
  • Oncolytic
  • Virus
  • HSV
  • Herpes Virus
  • G207
  • Oncolytic Herpes Virus

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by M.D. Anderson Cancer Center on 2026-09-04.