Recruiting

Observational Study

Sponsor:

University of Southern California

Code:

NCT03916562

Conditions

Stroke

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Accepted

Interventions

Manipulation of spatiotemporal coordination during walking

Study Details

Brief summary:

This project seeks to identify the how walking impairments in stroke survivors contribute to mobility deficits through the use of behavioral observations and computational models. The chosen approach integrates biomechanical analyses, physiological assessments and machine learning algorithms to explain how asymmetries during walking influence balance and the effort required to walk. Ultimately, the results of this work may lead to more personalized rehabilitation strategies to improve walking capacity and efficiency, and ultimately reduce fall risk in stroke survivors.

Conditions

Stroke

Study ID

NCT03916562

Start date

Nov 13, 2018

Status verified date

May, 2023

Completion date

Nov 30, 2023

Anticipated

Primary completion date

Nov 30, 2023

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Accepted

Inclusion Criteria for Control Participants:

  • No musculoskeletal injury or conditions that limit walking ability
  • No history of neurological disorders or severe head trauma
  • Absence of cognitive impairment as demonstrated by a Mini-Mental score greater than 24

Inclusion Criteria for Post-Stroke Participants

  • Presence of unilateral brain lesion from a single stroke
  • Weakness confined to one side
  • Ability to walk on a treadmill for five minutes continuously without a cane or walker
  • Absence of cognitive impairment as demonstrated by a Mini-Mental score greater than 24

Study Design

Enrollment

108 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Healthy Participants

The investigators will determine how asymmetric walking constraints influence spatiotemporal coordination, energetic cost, and dynamic balance in healthy individuals. The investigators will manipulate spatiotemporal coordination using a special treadmill. Energetic cost will be quantified using expired gas analysis and inverse dynamic approaches. Stability will be evaluated by characterizing participants' ability to recover from unexpected perturbations.

experimental: Post-stroke Participants

The investigators will determine how different patterns of coordination during walking influence energetic cost and dynamic balance in people post-stroke. The investigators will manipulate coordination using a special treadmill. Energetic cost will be quantified using expired gas analysis and inverse dynamic approaches. Stability will be evaluated by characterizing participants' ability to recover from unexpected perturbations.

Interventions

Manipulation of spatiotemporal coordination during walking

A description of the intervention is included in the description of the study arms.

Primary outcome measure

  • Oxygen consumption (VO2) [ Time Frame: At the beginning of study day one ]
  • Correlation between oxygen consumption (VO2) and step length asymmetry [ Time Frame: During study day one ]
  • Angular momentum during walking [ Time Frame: At the beginning of study day two ]
  • Correlation between angular momentum and step length asymmetry during walking [ Time Frame: During study day two ]

Central Contacts and Locations

Central contacts

James Finley, Ph.D.

3234424837jmfinley@pt.usc.edu

Locations

University of Southern California

Recruiting

Los Angeles, California, United States, 90033

Contacts

James Finley, PhD

323-442-4837jmfinley@pt.usc.edu

More Information

Sponsor

University of Southern California

Last update posted

May 23, 2023

Last verified

May, 2023

Keywords

  • Walking
  • Gait
  • Stability
  • Energetic cost

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Southern California on 2023-05-23.