Recruiting

T-Cell Repertoire

Sponsor:

University of Southern California

Code:

NCT03921047

Conditions

Acute Myeloid Leukemia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection

Laboratory Biomarker Analysis

Study Details

Brief summary:

This research trial studies characterization of T-cell repertoire through next-generation sequencing in patients with acute myeloid leukemia undergoing stem cell transplant. Characterizing T-cell repertoire may help to understand if immune system plays a significant role in high risk patients with acute myeloid leukemia.

Conditions

Acute Myeloid Leukemia

Study ID

NCT03921047

Start date

Apr 12, 2018

Status verified date

May, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of AML scheduled to undergo HSCT at University of Southern California (USC)

Exclusion Criteria:

  • Inability to provide consent because of severe mental disorders
  • Donor unwilling to provide consent

Study Design

Enrollment

250 participants

Anticipated

Interventions and Outcome Measures

Arms

Ancillary-correlative (next generation sequencing)

Patents undergo collection of blood samples before, on day 100, and 1 year after HSCT. Donors undergo collection of blood at the time of HSCT for RNA-based next generation sequencing of TCRA and TCRB genes.

Interventions

Biospecimen Collection

Undergo collection of blood samples

Laboratory Biomarker Analysis

Correlative studies

Primary outcome measure

  • Time to diagnosis of acute graft versus (vs.) host disease (aGVHD) [ Time Frame: Up to 4 years ]
  • Time to diagnosis of relapse [ Time Frame: Up to 4 years ]

Central Contacts and Locations

Central contacts

Christine Duran

323-865-0371Duran_C@med.usc.edu

Locations

USC / Norris Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Houda Alachkar

323-442-2696alachkar@usc.edu

Principal Investigator:

Houda Alachkar

More Information

Sponsor

University of Southern California

Last update posted

Jun 3, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Southern California on 2026-06-03.