Recruiting

Observational Study

Sponsor:

Centre Hospitalier Universitaire de Besancon

Code:

NCT03931148

Conditions

Decision Making

Dementia

Aging

Eligibility Criteria

Sex: All

Age: 70+

Healthy Volunteers: Not accepted

Interventions

Geriatric Assesment with neuropsychological test more specific on decision making

Functional RMI

High Resolution EEG

Qualitative interview

Study Details

Brief summary:

IMAGISION aims to explore, in a cohort of patients referred for geriatric consultation for neurocognitive evaluation, the contribution of functional neuroimaging (functional MRI and, if possible, high resolution EEG) to geriatric expertise, associated with the performance of a battery of neuropsychological tests in the evaluation of decision-making capacity.

Conditions

Decision Making

Dementia

Aging

Study ID

NCT03931148

Start date

Jan 5, 2020

Status verified date

Aug, 2021

Completion date

Apr, 2023

Anticipated

Primary completion date

Sep, 2022

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • French speaker
  • Recent diagnosis of neurocognitive disorder
  • Agreed with the study

Exclusion Criteria:

  • Delirium
  • Major depressive symptoms
  • MRI contraindication

Study Design

Enrollment

74 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Intervention

After first consultation for diagnosis of neurodegenerative disorder :

  • Geriatric Assessment with specific neuropsychologic tests of decision making
  • fRMI
  • EEG High Resolution
  • Qualitative interview

Interventions

Geriatric Assesment with neuropsychological test more specific on decision making

The following tests will be made : MoCA, FAB, TMT, Stroop-Victoria, JAT

Functional RMI

With specific test of decision making (IGT) specially adapted to the population

High Resolution EEG

With specific test of decision making (BART) specially adapted to the population

Qualitative interview

Qualitative semi-directed interviews with participants, their caregivers and their geriatrician to analyse everyday life decision making ability.

Primary outcome measure

  • Estimation of concordance/disordance between the standardized global gerontological evaluation and the objectification of the activation zones of prefrontal ventromedial and dorsolateral cortex by functional imaging [ Time Frame: 1 ]

Central Contacts and Locations

Central contacts

Thomas TANNOU, MD

+33381669003ttannou@chu-besancon.fr

Aurelie MARCEAU, PhD

++33677132916amarceau@chu-besancon.fr

Locations

CRIUGM

Recruiting

Montreal, Quebec, Canada, H3W1W6

Contacts

Thomas TANNOU, MD

+15143403540thomas.tannou@umontreal.ca

Sven JOUBERT, PhD

+15143403540sven.joubert@umontreal.ca

Principal Investigator:

Sven JOUBERT, PhD

More Information

Sponsor

Centre Hospitalier Universitaire de Besancon

Last update posted

Aug 23, 2021

Last verified

Aug, 2021

Keywords

  • Neuroimaging
  • Dementia
  • Decision making
  • Neuropsychology
  • Aging

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Centre Hospitalier Universitaire de Besancon on 2021-08-23.