Recruiting

Pediatric Liver Cancer

Sponsor:

University of Pittsburgh

Code:

NCT03959800

Conditions

Childhood Liver Cancer

Liver Malignant Tumors

Embryonal Sarcoma of Liver (Disorder)

Hepatoblastoma

Hepatocellular Carcinoma

Eligibility Criteria

Sex: All

Age: 0 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this retrospective and prospective project is to understand the molecular and genetic basis of liver cancer of childhood. Understanding the molecular and genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition.

Conditions

Childhood Liver Cancer

Liver Malignant Tumors

Embryonal Sarcoma of Liver (Disorder)

Hepatoblastoma

Hepatocellular Carcinoma

Study ID

NCT03959800

Start date

Jun 22, 2015

Status verified date

Aug, 2026

Completion date

Jun 30, 2035

Anticipated

Primary completion date

Jun 30, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Prior or current treatment for a childhood liver tumor, malignant or benign, at age <21 years.
  • Biological parents and siblings of eligible children.

Exclusion Criteria:

  • No prior or current treatment for a childhood liver tumor.
  • Non-biological parents, legal guardians, or non-biological siblings of eligible children.

Study Design

Enrollment

1600 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Gene sequencing [ Time Frame: Recurrence free survival at 2 years ]
  • Gene expression analysis [ Time Frame: Recurrence free survival at 2 years ]
  • Status of genome-wide chromatin accessibility [ Time Frame: Duration of active chemotherapy to two years after surgical treatment ]
  • Epigenetic change [ Time Frame: Duration of active chemotherapy to two years after surgical treatment ]
  • Tumor infiltrating cells which express immune checkpoints [ Time Frame: Duration of active chemotherapy to two years after surgical treatment ]

Central Contacts and Locations

Central contacts

Morgan Paul, BSN

(412) 692-8472Morgan.Paul2@upmc.edu

Daniel Pieratt, MPA

(412) 692-6692pierattdw@upmc.edu

Locations

UPMC Children's Hospital of Pittsburgh

Recruiting

Pittsburgh, Pennsylvania, United States, 15224

Contacts

Morgan L Paul, BSN

412-692-8472Morgan.Paul2@upmc.edu

Daniel Pieratt, MPA

4126926692pierattdw@upmc.edu

Principal Investigator:

Rakesh Sindhi, MD

More Information

Sponsor

University of Pittsburgh

Last update posted

Aug 10, 2026

Last verified

Aug, 2026

Keywords

  • Hepatoblastoma
  • Hepatocellular Carcinoma
  • Pediatric Liver Cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Pittsburgh on 2026-08-10.