Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT03980886

Conditions

Eosinophilic Esophagitis

Eligibility Criteria

Sex: All

Age: 1 - 65

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Single center observational and specimen banking study for children with eosinophilic esophagitis EoE to gauge natural history and inflammatory markers

Conditions

Eosinophilic Esophagitis

Study ID

NCT03980886

Start date

Feb 11, 2019

Status verified date

Jun, 2026

Completion date

Dec 17, 2028

Anticipated

Primary completion date

Dec 17, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 1 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Have a known EoE diagnosis
  • Complain of dysphagia, vomiting, or abdominal pain, especially if recalcitrant to acid blocking therapy (but does not have to be recalcitrant to acid blocking medications)
  • Present with food impaction
  • Present with esophageal stricture
  • Have characteristic endoscopic findings of EoE of pallor, linear furrows, lichenification, white plaques, or concentric rings

Exclusion Criteria:

  • None

Study Design

Enrollment

1500 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • The longitudinal trajectory of symptoms, endoscopy, and histology in pediatric EoE during routine clinical care [ Time Frame: 10 years ]
  • The longitudinal trajectory of inflammatory markers in blood and biopsies in pediatric EoE during routine clinical care [ Time Frame: 10 years ]

Central Contacts and Locations

Central contacts

Angie Rodriguez Verdin, BS

8589661700anrodriguezverdin@health.ucsd.edu

Seema S Aceves, MD, PhD

8585342983saceves@ucsd.edu

Locations

Rady Children's Hospital San Diego

Recruiting

San Diego, California, United States, 92123

Contacts

Angie Rodriguez Verdin, BS

8589661700anrodriguezverdin@health.ucsd.edu

Seema Aceves, MD,PhD

8589665961saceves@ucsd.edu

Principal Investigator:

Seema Aceves, MD.PhD

More Information

Sponsor

University of California, San Diego

Last update posted

Jul 7, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Diego on 2026-07-07.