Recruiting
Phase 2

Partial Breast Radiation Therapy

Sponsor:

Memorial Sloan Kettering Cancer Center

Code:

NCT04084730

Conditions

Invasive Ductal Breast Carcinoma

Invasive Ductal Carcinoma, Breast

DCIS

DCIS Grade 1

DCIS Grade 2

Eligibility Criteria

Sex: Female

Age: 45+

Healthy Volunteers: Not accepted

Interventions

Accelerated Partial Breast Irradiation

Study Details

Brief summary:

The purpose of this study is to determine if the dose of radiation therapy that is effective in producing a treatment response, delivered over a shorter treatment period, is a safe approach that causes few or mild side effects in women with newly diagnosed breast cancer or DCIS who have had a lumpectomy procedure.

Conditions

Invasive Ductal Breast Carcinoma

Invasive Ductal Carcinoma, Breast

DCIS

DCIS Grade 1

DCIS Grade 2

Study ID

NCT04084730

Start date

Aug 30, 2019

Status verified date

Sep, 2025

Completion date

Aug 30, 2026

Anticipated

Primary completion date

Aug 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 45+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Female
  • Age >/= 45 years
  • Unicentric pathological stage I (pT1 or T2 pN0\_M0) invasive ductal breast cancer or DCIS measuring <3 cm in longest diameter on pathology and/or mammogram that is histologically confirmed. If T2, the tumor must be less than 3cm in longest diameter. Note: Women ≥ 70 years or older with T1 invasive ductal carcinoma who are estrogen- receptor positive (ER+) with clinically negative axillary nodes, and do not undergo surgical lymph node mapping or dissection (i.e., if tumor deposit is 0.2 mm or less, regardless of whether the deposit is detected by immunohistochemistry or hematoxylin and eosin staining) will also be eligible. Patients age 50 or older who are clinically node-negative by physical exam and ultrasound and have a primary tumor that is <=2 cm and hormone-receptor positive, are also eligible.
  • Histologically negative tumor margin or no tumor in a re-excision specimen on final shaved specimen.
  • ECOG Performance Status of 0 or 1.
  • Negative serum pregnancy test within 14 days prior to study treatment if a woman has child-bearing potential. Subjects of child bearing potential are those who have not been surgically sterilized or have not been free from menses for > 1 year
  • Written informed consent obtained from subject and ability for subject or comply with the requirements of the study
  • Female subjects of childbearing potential should be willing to use 2 methods or birth control or be surgically sterile or abstain from heterosexual activity for the duration of study participation. Should a woman become pregnant while participating on study, she should inform the treating physician immediately.

Inclusion Criteria for intermediate risk substudy:

  • Post-NAC cohort patients: clinical T1-T2 (less than or equal to 5cm in longest diameter on available imaging) and clinical N0-N1 (on exam and imaging) with pathological ypT0, ypTis, or ypT1 (<=2cm) and ypN0 (any regimen of neoadjuvant chemotherapy agents is allowed)

OR

  • Oncotype RS score of 26 or higher

OR

  • PAM50 ROR scored as "HIGH"

OR

  • Presence or LVI (focal, limited or "not otherwise specified") in the lumpectomy specimen

OR

  • Age 40-49 years (ALL OF THE FOLLOWING MUST BE TRUE : 1) no history of prior benign breast biopsies, 2) no concomitant or prior atypia in either breast, 3) no concomitant or prior LCIS in either breast, 4) no family history of breast cancer in first degree relatives)

OR

  • Invasive lobular carcinoma

OR

  • Surgical margins less than 1 mm to invasive or in-situ disease.

Exclusion Criteria:

  • Patients with distant metastasis
  • Patients who are pregnant or breastfeeding
  • Patients with diffuse (>1 quadrant or >5cm) suspicious microcalcifications or patients with known multicentric OR multifocal disease. (microscopic multifocal disease that may be unifocal and/or appear multifocal due to sectioning is allowed after review with PI).
  • Prior radiation therapy to the ipsilateral or contralateral breast or thorax.
  • Histological evidence of extensive lymphovascular invasion (LVI)
  • Histological evidence of extensive intraductal component (EIC), defined as the presence of intraductal carcinoma both within the primary infiltrating ductal tumor (comprising at least 25% of the tumo area) and intraductal carcinoma present clearly beyond the edges of the invasive tumor.
  • Patients are not required to undergo BRCA1 and BRCA2 or other genetic mutation tests in order to enroll on the study. Note: in the event a patient is tested and is found to be a mutation carrier, she would be excluded from the study. It would be an extremely rare/unlikely scenario for patients to be discovered BRCA positive after the completion of PBI, as all patients with risk factors for BRCA mutations (positive family history, Ashkenazi Jewish descent, ER-/PR-/her2-neu-negative receptor status) are usually tested prior to radiation. Should such a situation exist, these patients will be given the option of remaining on the breast conservation paradigm or opting for mastectomy (as is done in this rare scenario is standard of care practice). The patient will be replaced on the trial.
  • History of cosmetic or reconstructive breast surgery.
  • Medical condition such as uncontrolled infection (including HIV), uncontrolled diabetes mellitus, or connective tissue diseases (lupus, systemic sclerosis, or other collagen vascular diseases) that, in the opinion of the treating physician, would make this protocol unreasonably hazardous for the patient.
  • Patients with a "currently active" second malignancy other than non-melanoma skin cancers. Patients are not considered to have "currently active" malignancies if they have completed therapy and are considered by their physicians to be at <5% risk of relapse within 3 years.
  • Patients who are already enrolled in or planning to enroll in other adjuvant systemic therapy protocols for both non-invasive or invasive breast cancer
  • Expecting to conceive within the projected duration of the trials, starting with screening visit through 180 days after the last dose of trial treatment
  • Concomitant anti-neoplastic treatment is not allowed during protocol treatment and should be completed at least 2 weeks prior to commencement of protocol treatment, with resolution of associated acute toxicities. Bisphosponates are permitted without restriction even during protocol treatment. Note: This does not apply to hormonal therapies such as tamoxifen or AIs, which are permitted. This does not apply to anti-Her2 therapies such as trastuzumab or TDM-1, which are also permitted.
  • Ongoing therapy with other investigational agents. Patients may not be receiving any other investigational agents.

Study Design

Enrollment

280 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Participants with Breast Cancer

Participants will have unicentric pathological stage I invasive ductal breast cancer or Grade 1 or 2 DCIS measuring <3cm in longest diameter on pathology and/or mammogram that is histologically confirmed at MSKCC.

Interventions

Accelerated Partial Breast Irradiation

Treatment will consist of APBI delivered using external beam RT techniques to a dose of 24 Gy in 3 fractions of 8.0 Gy delivered on consecutive weekdays

Primary outcome measure

  • Toxicity with novel APBI schedule as determined by CTCAE version 5 [ Time Frame: 24 months ]

Central Contacts and Locations

Central contacts

Atif J Khan, MD

848-225-6334khana7@mskcc.org

Simon Powell, MD, PhD

212-639-3639powells@mskcc.org

Locations

Norwalk Hospital

Recruiting

Norwalk, Connecticut, United States, 06850

Contacts

Philip Gilbo, MD

203-845-4811

Baptist Alliance Miami Cancer Institute

Recruiting

Miami, Florida, United States, 33143

Contacts

Joseph Panoff, MD

786-596-2000

Memorial Sloan Kettering Basking Ridge

Recruiting

Basking Ridge, New Jersey, United States, 07920

Contacts

Atif J Khan, MD

848-225-6334

Memorial Sloan Kettering Monmouth

Recruiting

Middletown, New Jersey, United States, 07748

Contacts

Atif J Khan, MD

848-225-6334

Memorial Sloan Kettering Bergen

Recruiting

Montvale, New Jersey, United States, 07645

Contacts

Atif J Khan, MD

848-225-6334

Memorial Sloan Kettering Commack

Recruiting

Commack, New York, United States, 11725

Contacts

Atif J Khan, MD

848-225-6334

Memorial Sloan Kettering Westchester

Recruiting

Harrison, New York, United States, 10604

Contacts

Atif J Khan, MD

848-225-6334

Memorial Sloan Kettering Cancer Center

Recruiting

New York, New York, United States, 10021

Contacts

Atif J Khan, MD

848-225-6334

Memorial Sloan Kettering Nassau

Recruiting

Uniondale, New York, United States, 11553

Contacts

Atif J Khan, MD

848-225-6334

More Information

Sponsor

Memorial Sloan Kettering Cancer Center

Last update posted

Sep 16, 2025

Last verified

Sep, 2025

Keywords

  • Unicentric pathological stage I breast invasive ductal breast cancer
  • Breast Cancer
  • Memorial Sloan Kettering Cancer Center
  • 19-300

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center on 2025-09-16.