Recruiting

Potassium

Sponsor:

University of Delaware

Code:

NCT04101188

Conditions

Cardiovascular Risk Factor

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Interventions

Moderate Potassium/Low Sodium Diet

Moderate Potassium/High Sodium Diet

High Potassium/High Sodium Diet

Study Details

Brief summary:

Americans continue to consume high amounts of sodium. Potassium is notable for its blood pressure lowering effects but less is known regarding its effect on the vasculature. This investigation seeks to determine the role of dietary potassium on the vasculature in the presence of a high sodium diet in salt-resistant adults.

Conditions

Cardiovascular Risk Factor

Study ID

NCT04101188

Start date

Jan 16, 2020

Status verified date

Mar, 2026

Completion date

Jul 31, 2026

Anticipated

Primary completion date

Jul 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

  • healthy
  • normal blood pressure
  • normal resting ECG

Exclusion Criteria:

  • hypertension
  • history of heart disease
  • diabetes
  • kidney disease
  • obese (BMI ≥30)
  • significant weight changes in the last 6 months
  • use of tobacco products
  • pregnant
  • on a special diet (gluten free; vegan)
  • take any medications for the above conditions
  • endurance trained athletes

Study Design

Enrollment

90 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Moderate Potassium/Low Sodium

Subjects will be provided with a diet that is moderate in potassium and low in sodium.

experimental: Moderate Potassium/High Sodium

Subjects will be provided with a diet that is moderate in potassium and high in sodium.

experimental: High Potassium/High Sodium

Subjects will be provided with a diet that is high in both potassium and sodium.

Interventions

Moderate Potassium/Low Sodium Diet

Consumption of 10 days of a diet moderate in potassium and low in sodium.

Moderate Potassium/High Sodium Diet

Consumption of 10 days of a diet moderate in potassium and high in sodium.

High Potassium/High Sodium Diet

Consumption of 10 days of a diet high in potassium and high in sodium.

Primary outcome measure

  • Conduit artery endothelial-dependent dilation [ Time Frame: on day 10 of the diet ]
  • Microvascular function [ Time Frame: on day 10 of the diet ]

Central Contacts and Locations

Central contacts

Shannon L Lennon, PhD

(302)831-2798slennon@udel.edu

Shannon L Lennon, PhD

3028312798slennon@udel.edu

Locations

University of Delaware

Recruiting

Newark, Delaware, United States, 19716

Contacts

Shannon L Lennon, PHD

302-831-2798slennon@udel.edu

More Information

Sponsor

University of Delaware

Last update posted

Mar 4, 2026

Last verified

Mar, 2026

Keywords

  • Dietary Potassium
  • Dietary Sodium
  • Vascular Health

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Delaware on 2026-03-04.