Recruiting

CHANGEGRADIENTS

Sponsor:

UCLA

Code:

NCT04110756

Conditions

Alcohol Drinking

Self Efficacy

Adolescent Behavior

Risk-Taking

Cancer

Eligibility Criteria

Sex: All

Age: 15 - 17

Healthy Volunteers: Accepted

Interventions

ChangeGradients

Study Details

Brief summary:

As most adolescents visit a healthcare provider once a year, health behavior change interventions linked to clinic-based health information technologies hold significant promise for improving healthcare quality and subsequent behavioral health outcomes for adolescents (Baird, 2014, Harris, 2017). Recognizing the potential to leverage recent advances in machine learning and interactive narrative environments, the investigators are now well positioned to design health behavior change systems that extend the reach of clinicians to realize significant impacts on behavior change for adolescent preventive health.

The proposed project centers on the design, development, and evaluation of a clinically-integrated health behavior change system for adolescents. CHANGEGRADIENTS will introduce an innovative reinforcement learning-based feedback loop in which adolescent patients interact with personalized behavior change interactive narratives that are dynamically personalized and realized in a rich narrative-centered virtual environment. CHANGEGRADIENTS will iteratively improve its behavior change models using policy gradient methods for Reinforcement Learning (RL) designed to optimize adolescents' achieved behavior change outcomes. This in turn will enable CHANGEGRADIENTS to generate more effective behavior change narratives, which will then lead to further improved behavior change outcomes. With a focus on risky behaviors and an emphasis on alcohol use, adolescents will interact with CHANGEGRADIENTS to develop an experiential understanding of the dynamics and consequences of their alcohol use decisions. The proposed project holds significant transformative potential for (1) producing theoretical and practical advances in how to realize significant impacts on adolescent health behavior change through novel interactive narrative technologies integrated with policy-based reinforcement learning, (2) devising sample-efficient policy gradient methods for RL that produce personalized behavior change experiences by integrating theoretically based models of health behavior change with data-driven models of interactive narrative generation, and (3) promoting new models for integrating personalized health behavior change technologies into clinical care that extend the effective reach of clinicians.

Conditions

Alcohol Drinking

Self Efficacy

Adolescent Behavior

Risk-Taking

Cancer

Study ID

NCT04110756

Start date

Feb 12, 2024

Status verified date

Oct, 2025

Completion date

Sep 30, 2026

Anticipated

Primary completion date

Jul 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 15 - 17

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adolescents between the ages of 15 and 17 years of age
  • Report current alcohol use
  • Presenting for a well-visit at UCSF Pediatric primary care clinics (the Mt. Zion Pediatric Primary Care Practices at UCSF and The Adolescent/Young Adult Clinic at UCSF)

Exclusion Criteria:

  • Non-English speakers

Study Design

Enrollment

200 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Treatment (ChangeGradients)

Adolescent participants will be introduced to the intervention through a brief introductory video trailer during their clinic visit and receive a link that enables them to engage with CHANGEGRADIENTS interactive narratives at home over a course of four weeks (i.e., one per week) on a personal computing device (e.g., laptop or tablet).

no intervention: No Intervention (Usual Care)

Participants will receive usual care at the clinic.

Interventions

ChangeGradients

CHANGEGRADIENTS is an interactive web-based tool which includes narrative-centered behavior change experiences that are dynamically generated.

Primary outcome measure

  • Mean scores on assessment of Alcohol Use [ Time Frame: 30 days ]
  • Mean score on a Self-efficacy tool developed by Drs Elizabeth Ozer and Dr. Albert Bandura [ Time Frame: 30 days ]
  • Quality of Care: Adolescent Report of the Visit (AROV) [ Time Frame: 1 day, immediately following baseline clinic visit ]

Central Contacts and Locations

Central contacts

Locations

University of California San Francisco Adolescent and Young Adult Medicine Clinic

Recruiting

San Francisco, California, United States, 94107

Contacts

Principal Investigator:

Elizabeth M Ozer, PhD

More Information

Sponsor

University of California, San Francisco

Last update posted

Oct 31, 2025

Last verified

Oct, 2025

Keywords

  • Alcohol- Prevention/Control
  • Adolescent behavior
  • Video games- psychology

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2025-10-31.