Recruiting
Early Phase 1

Cryo-Ablation

Sponsor:

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Code:

NCT04122807

Conditions

Atrioventricular Node Arrhythmia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Cardiac catheter ablation

Study Details

Brief summary:

In this study a new technique for ablation in atrioventricular nodal reentrant tachycardia using cryo-energy will be studied in cases where the standard approach has higher risk.

Conditions

Atrioventricular Node Arrhythmia

Study ID

NCT04122807

Start date

Nov, 2019

Status verified date

Nov, 2019

Completion date

Dec, 2021

Anticipated

Primary completion date

Dec, 2021

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Documented supraventricular tachycardia (SVT)
  • Planned to undergo electrophysiology (EP) study and ablation
  • PR interval on ECG <220ms (Group 1) or >220ms (Group 2)

Exclusion Criteria:

  • Pregnancy
  • Age <18 years
  • Inability to provide consent
  • High likelihood of tachycardia mechanism other than AVNRT (e.g. Pre-excitation on surface ECG, atrial tachycardia)

Study Design

Enrollment

20 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Mapping

Standard treatment involving ablation of the slow pathway with cryotherapy

experimental: Ablation

Mapping and ablation of the retrograde fast pathway with cryotherapy

Interventions

Cardiac catheter ablation

Cryoablation

Primary outcome measure

  • Termination of AVNRT [ Time Frame: One day ]

Central Contacts and Locations

Central contacts

Matthew K Rowe, MBBS

1-519-663-3746matthew.rowe@lhsc.on.ca

Allan Skanes, MD

1-519-663-3746allan.skanes@lhsc.on.ca

Locations

Lawson Health Research Institute

Recruiting

London, Ontario, Canada, N6A5A5

Contacts

Matthew K Rowe, MBBS

1-519-663-3746matthew.rowe@lhsc.on.ca

Allan Skanes, MD

1-519-663-3746allan.skanes@lhsc.on.ca

Principal Investigator:

Allan Skanes, MD

More Information

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Last update posted

Nov 20, 2019

Last verified

Nov, 2019

Keywords

  • AVNRT
  • Cryoablation
  • PR interval

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's on 2019-11-20.