Recruiting

Observational Study

Sponsor:

University of Massachusetts, Amherst

Code:

NCT04141722

Conditions

Sleep

Age

Emotional Valence

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Overnight sleep

Wake

Study Details

Brief summary:

Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression. Conversely, reactivating positive memories has been shown to reduce stress and symptoms of depression. In young adults, sleep is widely implicated in emotional processing, including consolidation of emotional memories. Evidence suggests that aging is associated with changes in emotion, including a positive memory bias and enhanced emotional well-being. These changes have been termed the "age-related positivity effect." However, the influence of sleep on these measures has not been investigated in healthy older individuals. The objective of this research is to understand the role of sleep in emotional memory consolidation and emotional well-being across adulthood. We hypothesize that sleep contributes to the age-related positivity effect in memory and affect. Our alternative hypothesis is that age-related decreases in sleep are responsible for reduced emotional memory processing over healthy aging.

Conditions

Sleep

Age

Emotional Valence

Study ID

NCT04141722

Start date

Dec 11, 2018

Status verified date

Oct, 2019

Completion date

May 31, 2020

Anticipated

Primary completion date

May 31, 2020

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18-30 or 50-80 years of age
  • Have no history of a sleep disorder
  • Have no history of neurological disease or injury
  • Have no history of psychiatric illness (anxiety or mood disorder, schizophrenia, etc.)
  • No history of chemotherapy
  • Not be taking medications which effect sleep
  • Habitually sleep more than 6 or more hours per night
  • Be able to walk freely and independently
  • Have normal to corrected-to-normal vision

Study Design

Enrollment

80 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Sleep

experimental: Wake

Interventions

Overnight sleep

Participant sent home to sleep overnight wearing PSG.

Wake

Participant sent to go about normal daily routine, instructed not to nap, drink caffeine, or engage in strenuous exercise.

Primary outcome measure

  • Memory bias [ Time Frame: 12 hr delay between encoding and recognition test ]

Central Contacts and Locations

Central contacts

Locations

University of Massachusetts, Amherst

Recruiting

Amherst, Massachusetts, United States, 01003

Contacts

More Information

Sponsor

University of Massachusetts, Amherst

Last update posted

Oct 28, 2019

Last verified

Oct, 2019

Keywords

  • Emotional Memory
  • Memory Consolidation
  • Age-Related Positivity Effect

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Massachusetts, Amherst on 2019-10-28.