Recruiting

Observational Study

Sponsor:

University of Rochester

Code:

NCT04142697

Conditions

Vestibular Disease

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Heading direction adaptation

Study Details

Brief summary:

The purpose this study is to measure sensitivity to visual and vestibular or balance motion. It is hoped that the results may help researchers better understand how aging and disease affect motion perception.

Conditions

Vestibular Disease

Study ID

NCT04142697

Start date

Sep 15, 2020

Status verified date

Dec, 2025

Completion date

Sep 1, 2027

Anticipated

Primary completion date

Sep 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

Healthy subjects:

  • general good health

Vestibular Disease patients:

  • general good health
  • specific unilateral or bilateral vestibular loss

Exclusion Criteria:

Healthy subjects:

  • subjects who are institutionalized or otherwise not self-sufficient.
  • enduring sequelae due to diseases of the nervous system, eyes, ears, head and neck, and limbs, except for changes commensurate with normal aging (e.g. presbyacusic hearing loss, mild cataract, etc.).
  • abnormal cognitive function, which if in question can be determined as a score of <27 on the Mini-Mental State test.
  • corrected visual acuity worse than 20/20 up to age 65, worse than 20/40 if >65
  • abnormal binocular stereo-acuity or visual fields.
  • any defects in cranial nerve, oculomotor, cerebellar/coordination, and somatosensory functions.
  • any abnormal oculomotor and vestibular function (caloric tests)

Vestibular Disease patients:

  • Inability to perform the study tasks due to sensory, motor, or postural limitations

Study Design

Enrollment

300 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

active comparator: Healthy subjects

active comparator: Vestibular Disease patients

Interventions

Heading direction adaptation

Will adapt subject's perceived heading direction using exposure to visual environments that include rotation and situations where visual and inertial heading direction are systematically offset.

Primary outcome measure

  • Change in Mean Heading perception [ Time Frame: Baseline to 1 week ]

Central Contacts and Locations

Central contacts

Cesar Arduino

585-273-2043Cesar_Arduino@urmc.rochester.edu

Locations

University of Rochester Medical Center

Recruiting

Rochester, New York, United States, 14618

Contacts

Cesar Arduino

585-273-2043Cesar_Arduino@urmc.rochester.edu

Paul D Allen, PhD

585-275-1186paul_allen@urmc.rochester.edu

More Information

Sponsor

University of Rochester

Last update posted

Jan 12, 2026

Last verified

Dec, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Rochester on 2026-01-12.