Recruiting

Genetic StudiesMolecular Genetics Studies of Cancer Patients and Their Relatives

Sponsor:

City of Hope Medical Center

Code:

NCT04185935

Conditions

Malignant Neoplasm

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Interventions

Biospecimen Collection

Questionnaire Administration

Study Details

Brief summary:

This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.

Conditions

Malignant Neoplasm

Study ID

NCT04185935

Start date

Apr 18, 1997

Status verified date

Jun, 2026

Completion date

Aug 18, 2033

Anticipated

Primary completion date

Aug 18, 2033

Anticipated

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Inclusion Criteria:

Individuals must have a personal history of cancer and/or a family history of cancer suggestive of the presence of an inherited predisposition. This inherited predisposition might manifest as:

Young age cancer diagnosis
Multiple primary neoplasms in affected member
The presence of rare tumor types in the family
Congenital malformations
Any other family clustering of cancer
Any other cancer-predisposing genetic diseases/conditions
Individuals may also be eligible by participation in the City of Hope Cancer Screening \& Prevention Program Network (CSPPN) clinical service or on the basis of membership in a group known or suspected to have an increased risk of carrying a genetic alteration or of sustaining a particular exposure that would place that at increased risk of cancer. (Examples would include members of occupational cohorts like asbestos workers, individuals with multiple dysplastic nevi in the absence of a family history of cancer, and individuals descended from a particular tribe in the American Southwest who have an increased incidence of a rare genetic alteration associated with an increased risk of a specific cancer.)
Individuals and families may be referred to us in a number of different ways. After initial contact is made with a individual or family by family studies personnel; an individual within the bloodline will be identified as the historian. There may be more than one historian within a family
At least one historian must be wiling to provide information or access as needed to contact appropriate family members for documentation of cancer and for consent. An individual is considered to be eligible to participate if they criteria; contact with relatives is not always indicated
Individuals who are under 18 are eligible for study if they meet the criteria. Consent for participation must be given by a legal guardian or parent
Deceased patients may be included in the study. Public records, such as death certificates, can be used to confirm information from individuals or family members. If medical records are needed, consent for these records will be obtained from the deceased's next of kin. Next of kin refers to the following hierarchy of relatives; spouse, offspring, parents, and siblings. (Any further use of next of kin in this protocol should relate back to this hierarchy.) Archived tissue samples, such as pathology blocks or snap frozen tumor from a pathology department tumor bank (discard specimens) may be used for genetic research

Exclusion Criteria:

A family may be ineligible for study if the historian will not allow access to anyone within the family and thus, the accuracy of the family history cannot be established

Study Design

Enrollment

999999 participants

Anticipated

Interventions and Outcome Measures

Arms

Ancillary-correlative (biospecimen collection)

Participants may provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of urine, and/or stored tumor or healthy tissue.

Interventions

Biospecimen Collection

Provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of urine, and/or stored tumor or healthy tissue

Questionnaire Administration

Ancillary studies

Primary outcome measure

Cancer risk assessment [ Time Frame: Up to 10 years ]
Exploratory biomarkers for future studies [ Time Frame: Up to 10 years ]

Central Contacts and Locations

Central contacts

Stephen Gruber

sgruber@coh.org

Locations

Valleywise Comprehensive Health Center - Phoenix

Recruiting

Phoenix, Arizona, United States, 85008

Contacts

Ian K. Komenaka

602-344-5368 Ian_Komenaka@dmgaz.org

Principal Investigator:

Ian K. Komenaka

John Muir Medical Center-Concord Campus

Recruiting

Concord, California, United States, 94520

Contacts

Shellie Campos

925-947-3322 shellie.campos@johnmuirhealth.com

Principal Investigator:

Shellie Campos

City of Hope Medical Center

Recruiting

Duarte, California, United States, 91010

Contacts

Jeffrey N. Weitzel

626-218-4334 jweitzel@coh.org

Principal Investigator:

Jeffrey N. Weitzel

Saint Jude Medical Center

Recruiting

Fullerton, California, United States, 92835

Contacts

William E. Lawler

714-446-5801 William.Lawlor@StJoe.org

Principal Investigator:

William E. Lawler

Saddleback Memorial Medical Center

Recruiting

Laguna Hills, California, United States, 92653

Contacts

Jeffrey N. Weitzel

626-218-4334 jweitzel@coh.org

Principal Investigator:

Jeffrey N. Weitzel

USC / Norris Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Charite Ricker

323-409-7710 Charite.Ricker@med.usc.edu

Principal Investigator:

Charite Ricker

Saint Joseph Hospital - Orange

Recruiting

Orange, California, United States, 92868

Contacts

Jeffrey N. Weitzel

626-218-4334 jweitzel@coh.org

Principal Investigator:

Jeffrey N. Weitzel

Sutter Cancer Centers Radiation Oncology Services-Roseville

Recruiting

Roseville, California, United States, 95661

Contacts

Kristie A. Bobolis

916-782-5106 bobolis@surewest.net

Principal Investigator:

Kristie A. Bobolis

Cancer Center of Santa Barbara

Recruiting

Santa Barbara, California, United States, 93105

Contacts

Frederic C. Kass

805-563-5854 fkass@ccsb.org

Principal Investigator:

Frederic C. Kass

Lynn Regional Cancer Center - West

Recruiting

Boca Raton, Florida, United States, 33428

Contacts

Louise E. Morrell

561-955-2141 LMorrell@brrh.com

Principal Investigator:

Louise E. Morrell

Holy Cross Hospital

Recruiting

Fort Lauderdale, Florida, United States, 33308

Contacts

Zdenka E. Segota

954-267-7709 Ena.segota@holy-cross.com

Principal Investigator:

Zdenka E. Segota

Kootenai Cancer Center

Recruiting

Post Falls, Idaho, United States, 83854

Contacts

Jeffrey W. Allen

208-625-4728 Mhander@kh.org

Principal Investigator:

Jeffrey W. Allen

John H Stroger Jr Hospital of Cook County

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Pamela Ganschow

312-864-4436 pganschow@cookcountyhhs.org

Principal Investigator:

Pamela Ganschow

Rush University Medical Center

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Lydia Usha

312-563-2200 Lydia_Usha@rush.edu

Principal Investigator:

Lydia Usha

Mercy Hospital

Recruiting

Cedar Rapids, Iowa, United States, 52403

Contacts

Amie Hass

319-398-6732 ahass@mercycare.org

Principal Investigator:

Amie Hass

Suburban Hospital

Recruiting

Bethesda, Maryland, United States, 20814

Contacts

Carolyn B. Hendricks

301-897-1503 carolyn.hendricks53@verizon.net

Principal Investigator:

Carolyn B. Hendricks

Frederick Oncology Hematology Associates

Recruiting

Frederick, Maryland, United States, 21702

Contacts

Patricia A. Rice

301-418-5010 price@fmh.org

Principal Investigator:

Patricia A. Rice

Steward Saint Elizabeth's Medical Center

Recruiting

Brighton, Massachusetts, United States, 02135

Contacts

Beth B. Herrick

617-789-3232 Beth.Herrick@steward.org

Principal Investigator:

Beth B. Herrick

Hunterdon Medical Center

Recruiting

Flemington, New Jersey, United States, 08822

Contacts

Kenneth B. Blankstein

908-788-2566 kblankstein@hhpnj.org

Principal Investigator:

Kenneth B. Blankstein

Lovelace Medical Center-Downtown

Recruiting

Albuquerque, New Mexico, United States, 87102

Contacts

Malcolm H. Purdy

505-727-3040 malcolm.purdy@ardenthealth.com

Principal Investigator:

Malcolm H. Purdy

New Mexico Oncology Hematology Consultants

Recruiting

Albuquerque, New Mexico, United States, 87109

Contacts

Annette C. Fontaine

505-480-1462 afontaine@nmohc.com

Principal Investigator:

Annette C. Fontaine

Presbyterian Kaseman Hospital

Recruiting

Albuquerque, New Mexico, United States, 87110

Contacts

Kenneth J. Smith

505-559-6143

Principal Investigator:

Kenneth J. Smith

Mount Kisco Medical Group at Northern Westchester Hospital

Recruiting

Mount Kisco, New York, United States, 10549-3417

Contacts

Nancy Cohen

914-242-7649 NCohen@nwhc.net

Principal Investigator:

Nancy Cohen

Health Quest Medical Practice PC-Cardio Thoracic

Recruiting

Poughkeepsie, New York, United States, 12601

Contacts

Jonathan Clyman

845-483-6279 jclyman@Health-quest.org

Principal Investigator:

Jonathan Clyman

Aultman Health Foundation

Recruiting

Canton, Ohio, United States, 44710

Contacts

Shruti Trehan

330-363-2286 Shruti.trehan@aultman.com

Principal Investigator:

Shruti Trehan

Saint Charles Health System

Recruiting

Bend, Oregon, United States, 97701

Contacts

Coralia B. Calomeni

541-706-5800 cbcalomeni@stcharleshealthcare.org

Principal Investigator:

Coralia B. Calomeni

Paoli Memorial Hospital

Recruiting

Paoli, Pennsylvania, United States, 19301

Contacts

Michael B. Dabrow

DabrowM@MLHS.ORG

Principal Investigator:

Michael B. Dabrow

Reading Hospital

Recruiting

West Reading, Pennsylvania, United States, 19611

Contacts

Terrence P. Cescon

484-628-8000 CesconT@readinghospital.org

Principal Investigator:

Terrence P. Cescon

The Don and Sybil Harrington Cancer Center

Recruiting

Amarillo, Texas, United States, 79106

Contacts

Anita Ravipati

aravipati@harringtoncc.org

Principal Investigator:

Anita Ravipati

Doctor's Hospital of Laredo

Recruiting

Laredo, Texas, United States, 78041

Contacts

Gary W. Unzeitig

956-726-3691 drgwu@laredobreastcare.com

Principal Investigator:

Gary W. Unzeitig

Covenant Medical Center

Recruiting

Lubbock, Texas, United States, 79410

Contacts

Isaac Tafur

806-725-7993 oncmd98@yahoo.com

Principal Investigator:

Isaac Tafur

Saint Agnes Hospital/Agnesian Cancer Center

Recruiting

Fond du Lac, Wisconsin, United States, 54935

Contacts

Michael W. Jones

920-926-4100

Principal Investigator:

Michael W. Jones

ProHealth Waukesha Memorial Hospital

Recruiting

Waukesha, Wisconsin, United States, 53188

Contacts

Christopher R. Hake

262-928-5539 chakemd@gmail.com

Principal Investigator:

Christopher R. Hake

Cheyenne Regional Medical Center-West

Recruiting

Cheyenne, Wyoming, United States, 82001

Contacts

Jennifer Van Horn

307-996-1517 Jennifer.VanHorn@crmcwy.org

Principal Investigator:

Jennifer Van Horn

More Information

Sponsor

City of Hope Medical Center

Last update posted

Jun 29, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by City of Hope Medical Center on 2026-06-29.