Recruiting

Magnetic Brain Stimulation

Sponsor:

University of Manitoba

Code:

NCT04193267

Conditions

Logopenic Progressive Aphasia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MagStim Rapid2 Transcranial Magnetic Simulation

Study Details

Brief summary:

The purpose of this study is to investigate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) - a form of non-invasive brain stimulation - to improve language functioning in individuals who have the logopenic variant of primary progressive aphasia (PPA-L) - a slowly progressive impairment of language, characterized by difficulties with word-finding, sentence repetition and sentence comprehension.

Conditions

Logopenic Progressive Aphasia

Study ID

NCT04193267

Start date

Jun 1, 2020

Status verified date

Mar, 2021

Completion date

Dec, 2022

Anticipated

Primary completion date

Aug, 2022

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of PPA-L (confirmed by a neurologist or neuropsychiatrist who has observed the patient for at least one year);
  • Mild to moderate language impairment as assessed by the Druks and Masterson Naming Task;
  • Native English speaker.

Exclusion Criteria:

  • Cerebrovascular disorders, hydrocephalus or intra-cranial mass, documented by MRI;
  • History of traumatic brain injury, seizures, or another neurological disease;
  • Significant medical problems (e.g. poorly controlled diabetes or hypertension or cancer within the past 5 years);
  • Major depressive disorder, bipolar disorder, schizophrenia, substance use disorder or mental retardation according to the criteria of the DSM-IV;
  • Any contraindication for rTMS (e.g., implanted metal devices; cardiac pacemaker or pacemaker wires; neurostimulators; implanted pumps, metal in the body \[rods, plates, screws, shrapnel, dentures, IUD\] or metallic particles in the body, surgical clips in the head, previous neurosurgery, cochlear implants, prosthetic heart valves);
  • Currently pregnant or breastfeeding.

Study Design

Enrollment

10 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Repetitive Transcranial Magnetic Stimulation (rTMS)

30 sessions of high-frequency (10Hz) repetitive stimulation applied over the posterior region of the left superior temporal gyrus in patients with logopenic primary progressive aphasia (PPA-L) using a MagStim Rapid2 Transcranial Magnetic Simulation machine.

Interventions

MagStim Rapid2 Transcranial Magnetic Simulation

A non-invasive method of brain stimulation

Primary outcome measure

  • Change in score on the Druks and Masterson Naming Task [ Time Frame: One week pre- and one week post-rTMS treatment ]

Central Contacts and Locations

Central contacts

Benjamin Meek

2042372677rtms@sbgh.mb.ca

Locations

St. Boniface Hospital

Recruiting

Winnipeg, Manitoba, Canada, R2H2A6

Contacts

Benjamin Meek

2042372677rtms@sbgh.mb.ca

More Information

Sponsor

University of Manitoba

Last update posted

Mar 22, 2021

Last verified

Mar, 2021

Keywords

  • Primary Progressive Aphasia
  • Brain Stimulation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Manitoba on 2021-03-22.