Recruiting

Sitting & Exercise

Sponsor:

University of Texas at Austin

Code:

NCT04195165

Conditions

Sedentary Behavior

Insulin Sensitivity

Sedentary Lifestyle

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Interventions

SIT

ACTIVE

EX

Study Details

Brief summary:

The investigators hypothesize that cycling for 1 hour of exercise at 65% peak oxygen consumption (VO2peak) after sitting >13 hr/day (SIT+EX) will not be different in postprandial plasma insulin responses compared to the control of only sitting (SIT). Furthermore, the investigators hypothesize that the SIT and SIT+EX groups will have a less favorble insulin response compared to the physically active group after performing the same 1-hour exercise bout (ACTIVE+EX).

Conditions

Sedentary Behavior

Insulin Sensitivity

Sedentary Lifestyle

Study ID

NCT04195165

Start date

Sep 23, 2019

Status verified date

Dec, 2019

Completion date

Sep 23, 2020

Anticipated

Primary completion date

Jun 30, 2020

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy, untrained/recreationally active men and women.
  • Women must not be pregnant or post-menopausal.

Exclusion Criteria:

  • Heart problems or coronary artery disease
  • Hypertension
  • Lung or respiratory problems
  • Chest pain, fainting, or heart palpitations during exercise, or told to give up sports because of health problems.

Study Design

Enrollment

12 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: SIT

Subject will be asked to take <3,000 steps for two intervention days prior to an oral glucose tolerance test on the third day.

experimental: SIT+EX

Subject will be asked to take <3,000 steps for two intervention days. On the evening of the second intervention day, the subject will cycle for one hour at 65% of VO2peak. The subject will undergo an oral glucose tolerance test on the morning of the third day.

experimental: ACTIVE+EX

Subject will be asked to take >10,000 steps for two intervention days. On the evening of the second intervention day, the subject will cycle for one hour at 65% of VO2peak. The subject will undergo an oral glucose tolerance test on the morning of the third day.

Interventions

SIT

For the SIT and SIT+EX conditions, the subject will be asked to take <3,000 steps. This is meant to achieve \~12-13 hours of sitting per day, are the investigators are measuring the effect of inactivity and exercise on insulin sensitivity.

ACTIVE

For the ACTIVE+EX condition, the subject will be asked to take >10,000 steps for the two intervention days. This is meant to simulate an active lifestyle.

EX

The SIT+EX and ACTIVE+EX conditions will include an exercise bout on the evening of the second intervention day, and have the oral glucose tolerance test the next morning.

Primary outcome measure

  • Insulin sensitivity [ Time Frame: Up to 4 weeks after data completion ]

Central Contacts and Locations

Central contacts

Michael B Dial

8018915699Michael.dial@utexas.edu

Locations

University of Texas at Austin

Recruiting

Austin, Texas, United States, 78712

Contacts

Michael B Dial

801-891-5699michael.dial@utexas.edu

More Information

Sponsor

University of Texas at Austin

Last update posted

Dec 11, 2019

Last verified

Dec, 2019

Keywords

  • glucose tolerance
  • exercise
  • insulin sensitivity

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Texas at Austin on 2019-12-11.