Recruiting

Ocular Surface

Sponsor:

Centre hospitalier de l'Université de Montréal (CHUM)

Code:

NCT04198740

Conditions

Dry Eye Syndrome

Infectious Keratoconjunctivitis

Mucous Membrane Pemphigoid

Allergic Conjunctivitis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Tear sample collection via Schirmer strip and subsequent analysis by mass spectrometry

Study Details

Brief summary:

This study aims to obtain the lacrimal fingerprint for frequent pathologies of the ocular surface and establish a normative base for each of them.

Conditions

Dry Eye Syndrome

Infectious Keratoconjunctivitis

Mucous Membrane Pemphigoid

Allergic Conjunctivitis

Study ID

NCT04198740

Start date

Feb 1, 2020

Status verified date

Apr, 2026

Completion date

Jan, 2035

Anticipated

Primary completion date

Oct, 2034

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Patients with healthy corneas or suffering from one of these pathologies:

Dry eye syndrome; Infectious keratitis and/or conjunctivitis; Mucous membrane pemphigoid; Allergic conjunctivitis.

Exclusion Criteria:

  • Patients younger than 18 years old;
  • Patients incapable of giving informed consent.

Study Design

Enrollment

300 participants

Anticipated

Interventions and Outcome Measures

Arms

Control group

Healthy, normal ocular surface

Dry eye syndrome

Patients suffering from either:

  • Lacrimal insufficiency
  • Anterior blepharitis
  • Posterior blepharitis
  • Sjögren syndrome

Allergic conjunctivitis

Patients suffering from allergic conjunctivitis

Mucous membrane pemphigoid

Patients suffering from mucous membrane pemphigoid

Infectious keratoconjunctivitis

Patients suffering from keratitis and/or conjunctivitis of various etiology:

  • Viral
  • Bacterial
  • Fungal
  • Acanthamoeba

Interventions

Tear sample collection via Schirmer strip and subsequent analysis by mass spectrometry

During regular consultations at the ophthalmology department of the CHUM, eligible patients will undergo a standard 5 minute Schirmer tear test. The Schirmer strips will serve as tear samples and will be sent to UQAM's Department of chemistry for mass spectrometry analysis.

Primary outcome measure

  • To obtain the metabolomic and proteomic fingerprint of the studied ocular surface pathologies [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Marie-Claude Robert, MD, M.Sc

514-890-8278marie-claude.robert.2@umontreal.ca

Marie-Catherine Tessier

514-890-8000marie-catherine.tessier.chum@ssss.gouv.qc.ca

Locations

Centre Hospitalier de l'Université de Montréal (CHUM)

Recruiting

Montreal, Quebec, Canada, H2X 3E4

Contacts

Marie-Claude Robert, MD, M.Sc

514-890-8278marie-claude.robert.2@umontreal.ca

Marie-Catherine Tessier

514-890-8000marie-catherine.tessier.chum@ssss.gouv.qc.ca

Principal Investigator:

Marie-Claude Robert, MD, M.Sc

More Information

Sponsor

Centre hospitalier de l'Université de Montréal (CHUM)

Last update posted

Apr 27, 2026

Last verified

Apr, 2026

Keywords

  • Lacrimal fingerprint
  • Metabolomics
  • Proteomics
  • Ocular surface

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Centre hospitalier de l'Université de Montréal (CHUM) on 2026-04-27.