Recruiting

Observational Study

Sponsor:

M.D. Anderson Cancer Center

Code:

NCT04216732

Conditions

Advanced Thyroid Gland Medullary Carcinoma

Stage III Thyroid Gland Medullary Carcinoma AJCC v8

Stage IV Thyroid Gland Medullary Carcinoma AJCC v8

Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8

Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Blood Pressure Measurement

Questionnaire Administration

Study Details

Brief summary:

This study utilizes a multi-institutional registry to describe the natural history of medullary thyroid cancer that has spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) in understanding disease management. The goal of this study is to learn about how medullary thyroid cancer develops and progresses.

Conditions

Advanced Thyroid Gland Medullary Carcinoma

Stage III Thyroid Gland Medullary Carcinoma AJCC v8

Stage IV Thyroid Gland Medullary Carcinoma AJCC v8

Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8

Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8

Study ID

NCT04216732

Start date

Jan 10, 2020

Status verified date

Mar, 2026

Completion date

Sep 1, 2026

Anticipated

Primary completion date

Sep 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Aims 1 and 2: A diagnosis of MTC
  • Aims 1 and 2: A registrant in the Medullary Thyroid Cancer Registry (MTCR). Patients of all disease phases will be eligible for enrollment
  • Aim 3: A diagnosis of advanced phase (red or gray) MTC as determined by clinical team
  • Aim 3: A current registrant in the MTCR

Study Design

Enrollment

2030 participants

Anticipated

Interventions and Outcome Measures

Arms

Observational (questionnaire, blood pressure)

AIM I \& II: Patients complete questionnaires over 10-40 minutes 2-4 times per year about health and how finances and quality of life effect experience with disease.

AIM III: Patients complete a questionnaire over 2 minutes and undergo blood pressure measurements every day for up to 12 weeks.

Interventions

Blood Pressure Measurement

Undergo blood pressure measurement

Questionnaire Administration

Complete questionnaires

Primary outcome measure

  • Natural history of medullary thyroid cancer (MTC) [ Time Frame: Up to 4 years ]
  • Patients' experience with the different phases of MTC [ Time Frame: Up to 4 years ]
  • Association of selected biometric and patient-reported outcomes [ Time Frame: Up to 4 years ]

Central Contacts and Locations

Central contacts

Elizabeth G Grubbs

713-792-6940eggrubbs@mdanderson.org

Locations

University of California San Francisco

Recruiting

San Francisco, California, United States, 94143

Contacts

Julie A. Sosa

415-476-1236

Principal Investigator:

Julie A. Sosa

M D Anderson Cancer Center

Recruiting

Houston, Texas, United States, 77030

Contacts

Elizabeth G. Grubbs

713-792-6940eggrubbs@mdanderson.org

Principal Investigator:

Elizabeth G. Grubbs

More Information

Sponsor

M.D. Anderson Cancer Center

Last update posted

Mar 5, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by M.D. Anderson Cancer Center on 2026-03-05.