Recruiting

Ketamine

Sponsor:

University of Oklahoma

Code:

NCT04248205

Conditions

Hemorrhoids

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Ketamine

Study Details

Brief summary:

This is a prospective, randomized study of ketamine versus no ketamine in approximately 100 patients undergoing hemorrhoidectomy for Grade III or IV hemorrhoids. The participants will be blinded to which treatment arm they are assigned, because participants will be under anesthesia when the ketamine is administered. The investigators will know whether the participant receives ketamine or not.

Conditions

Hemorrhoids

Study ID

NCT04248205

Start date

Jun 15, 2020

Status verified date

Mar, 2026

Completion date

Jul, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults aged 18-100
  • Undergoing a hemorrhoidectomy for Grade III or IV hemorrhoids.

Exclusion Criteria:

  • Inability to undergo general anesthesia
  • Contraindications to hemorrhoidectomy
  • History of schizophrenia or other hallucinatory psychiatric illnesses
  • History of psychosis
  • Chronic narcotic usage defined as either having a pain contract with a pain management specialist and no narcotic usage for one month prior to hemorrhoidectomy.

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Intraoperative ketamine infusion

Subjects in this group will receive standard anesthesia during surgery and a dose of ketamine at 0.3 mg/kg IV bolus prior to surgical incision. If the procedure lasts more than 1 hour, an additional bolus dose will be given.

no intervention: Control group

This group will only receive the standard anesthesia during surgery with no ketamine.

Interventions

Ketamine

Standard general anesthesia PLUS ketamine will be given for post-operative analgesia

Primary outcome measure

  • Change in post-operative narcotic usage [ Time Frame: two weeks post-operation ]

Central Contacts and Locations

Central contacts

Steven N Carter, MD

405-271-8001steven-carter@ouhsc.edu

Locations

University of Oklahoma Health Sciences Center

Recruiting

Oklahoma City, Oklahoma, United States, 73104

Contacts

Steven Carter

405-271-8001steven-carter@ouhsc.edu

More Information

Sponsor

University of Oklahoma

Last update posted

Apr 1, 2026

Last verified

Mar, 2026

Keywords

  • hemorrhoidectomy
  • ketamine
  • post operative pain

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Oklahoma on 2026-04-01.