Recruiting
Phase 3

Venetoclax & Obinutuzumab

Sponsor:

National Cancer Institute (NCI)

Code:

NCT04269902

Conditions

Chronic Lymphocytic Leukemia

Small Lymphocytic Lymphoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection

Bone Marrow Aspiration

Bone Marrow Biopsy

Computed Tomography

Obinutuzumab

Study Details

Brief summary:

This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with the venetoclax and obinutuzumab early (before patients have symptoms) may have better outcomes for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma compared to starting treatment with the venetoclax and obinutuzumab after patients show symptoms.

Conditions

Chronic Lymphocytic Leukemia

Small Lymphocytic Lymphoma

Study ID

NCT04269902

Start date

Mar 2, 2021

Status verified date

Jun, 2026

Completion date

Oct 1, 2028

Anticipated

Primary completion date

Oct 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Participants must have a confirmed diagnosis of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) (collectively referred to as CLL throughout) according to the 2018 International Workshop on CLL. Participants must have been diagnosed within 18 months prior to registration
  • Participants must have CLL-International Prognostic Index (CLL-IPI) score >= 4 and/or complex cytogenetics (defined as 3+ chromosomal abnormalities)
  • Cytogenetic AND/OR FISH analyses must be completed at a Clinical Laboratory Improvement Act (CLIA)-approved (or laboratories accredited under Accreditation Canada Diagnostics to conduct FISH analyses) laboratory within 18 months prior to registration. At minimum, FISH panel should use probes to detect for abnormalities in chromosomes 13q, 12, 11q, and 17p
  • TP53 gene mutation analysis performed at any CLIA-approved (or laboratories accredited under Accreditation Canada Diagnostics) lab (if completed) must be obtained within 18 months prior to registration. This sequencing test is distinct from FISH studies for del(17p)

  • Note: TP53 gene mutation analysis is recommended but not required if the participant meets disease-related study criteria via a combination of risk factors that totals a score of 4 on the CLL-IPI score and/or has complex cytogenetics completed
  • Immunoglobulin heavy chain locus variable (IgVH) gene mutation analysis performed at any CLIA-approved lab (or laboratories accredited under Accreditation Canada Diagnostics) must be obtained prior to registration (at any time prior to registration)
  • Serum beta-2 microglobulin level must be obtained within 28 days prior to registration
  • Participants must not meet any of the IWCLL specified criteria for active CLL therapy
  • Treatment with high dose corticosteroids and/or intravenous immunoglobulin for autoimmune complications of CLL must be complete at least 4 weeks prior to enrollment
  • Steroids used for treatment of conditions other than CLL/SLL must be at a dose of at most 20 mg/day of prednisone or equivalent corticosteroid at the time of registration
  • Prior therapy with anti CD20 monoclonal antibodies is not allowed
  • Participants must not have received or be currently receiving any prior CLL-directed therapy, including non-protocol-related therapy, anti-cancer immunotherapy, experimental therapy (with exception of agents approved for emergency access use for the prevention or treatment of coronavirus disease 2019 \[COVID-19\]), or radiotherapy
  • Participants must not be receiving or planning to receive any other investigational agents before completing protocol therapy
  • Participants must be >= 18 years of age
  • Participants must have Eastern Cooperative Oncology Group (ECOG) performance status =< 2
  • Platelet count >= 100,000/mm\^3 within 28 days prior to registration
  • Absolute neutrophil count (ANC) >= 1,000/mm\^3 within 28 days prior to registration
  • Creatinine clearance >= 30mL/min (by Cockcroft Gault) within 28 days prior to registration
  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3.0 x upper limit of normal (ULN) within 28 days prior to registration
  • Total bilirubin =< 2.0 x ULN (or 5.0 x ULN if the participant has a history of Gilbert's disease), within 28 days prior to registration
  • Participants must be able to take oral medications
  • Human immunodeficiency virus (HIV)-infected participants on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
  • Participants with history of malignancy are allowed providing the cancer has not required active treatment within 2 years prior to registration (hormonal therapy is permissible). The following exceptions are permissible: basal cell, squamous cell skin, or non-melanomatous skin cancer, in situ cervical cancer, superficial bladder cancer not treated with intravesical chemotherapy or Bacillus Calmette-Guerin (BCG) within 6 months, localized prostate cancer treated with surgical resection and/or radiation only or requiring no more than chronic hormonal therapy, or prostate cancer with Gleason score ≤ 6, or localized breast cancer treated with surgical resection and/or radiation only or requiring no more than chronic hormonal therapy
  • Participants must not have current, clinically significant gastrointestinal malabsorption, in the opinion of treating doctor
  • Participants must not have cirrhosis
  • Obinutuzumab has been associated with hepatitis reactivation. Participants must not have uncontrolled active infection with hepatitis B or C. Participants with latent hepatitis B infection must agree to take prophylaxis during and for 6 months following active protocol therapy with V-O.

  • Active infection with hepatitis B or C:

  • Active infection is defined as detectable hepatitis B deoxyribonucleic acid (DNA) or hepatitis C ribonucleic acid (RNA) by quantitative polymerase chain reaction (PCR).
  • Latent infection with hepatitis B:

  • Latent infection is defined as meeting all of the following criteria:

  • Hepatitis B surface antigen positive
  • Anti-hepatitis B total core antibody positive
  • Anti-hepatitis IgM core antibody undetectable
  • Hepatitis B PCR undetectable
  • Participants with latent hepatitis B infection must agree to take prophylaxis with anti-hepatitis agents during and for 6 months following active protocol therapy with V-O.
  • Participants who have received intravenous immunoglobulin (IVIG) therapy within 6 months who are hepatitis B core total antibody positive but PCR undetectable are not mandated to take prophylaxis
  • Participants must not have had major surgery within 30 days prior registration or minor surgery within 7 days prior to registration. Examples of major surgery include neurosurgical procedures, joint replacements, and surgeries that occur inside the thoracic or abdomino-pelvic cavities. Examples of minor surgery include dental surgery, insertion of a venous access device, skin biopsy, or aspiration of a joint. If a participant has had a bone marrow biopsy for diagnosis or evaluation of CLL, this will not exclude the participant from registration to the study. If there is a question about whether a surgery is major or minor, this should be discussed with the Study Chair
  • Participants must not have known bleeding disorders (e.g., von Willebrand's disease or hemophilia)
  • Participants must not have a history of stroke or intracranial hemorrhage within 6 months prior to enrollment
  • Participants must not require continued therapy with a strong inhibitor or inducer of CYP3A4/5, as venetoclax is extensively metabolized by CYP3A4/5
  • Participants must not have uncontrolled autoimmune hemolytic anemia or idiopathic thrombocytopenia purpura
  • Participants must not have any currently active, clinically significant cardiovascular disease, such as uncontrolled arrhythmia or class 3 or 4 congestive heart failure as defined by the New York Heart Association Functional Classification
  • Participants must not have a history of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to enrollment
  • Participants must not be pregnant or nursing, as there are no safety data available for these drug regimens during pregnancy. Women/men of reproductive potential must have agreed to use an effective contraceptive method. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
  • Participants must agree to have specimens submitted for translational medicine (MRD) as outlined
  • Participants must be offered the opportunity to participate in specimen banking for future research as outlined.

  • NOTE: With participant's consent, the site must follow through with specimen submission as outlined
  • Participants who are able to complete patient reported outcome (PRO) forms in English, Spanish, French, German, Russian or Mandarin must be offered the opportunity to participate in the quality of life assessments. (Those participants who are unable to read and write in English, Spanish, French, German, Russian or Mandarin may be registered to S1925 without contributing to the quality of life portion of the study.)
  • Participants must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
  • NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

Study Design

Enrollment

247 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Arm I (delayed V-O)

Treatment begins once 2018 IWCLL indications are met. Patients receive obinutuzumab IV on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo CT, collection of blood samples, and bone marrow aspiration and biopsy during follow-up.

experimental: Arm II (early V-O)

Treatment begins as soon as eligibility criteria are met. Patients receive obinutuzumab IV on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo CT, collection of blood samples, and bone marrow aspiration and biopsy during follow-up.

Interventions

Biospecimen Collection

Undergo collection of blood samples

Bone Marrow Aspiration

Undergo bone marrow aspiration

Bone Marrow Biopsy

Undergo bone marrow biopsy

Computed Tomography

Undergo CT

Obinutuzumab

Given IV

Questionnaire Administration

Ancillary studies

Venetoclax

Given PO

Primary outcome measure

  • Overall survival (OS) [ Time Frame: From the day of registration on study until death from any cause with observations censored on the day of last contact for participants not known to have died, assessed up to 10 years ]
  • Functional Assessment of Cancer Therapy (FACT)-Leukemia total score [ Time Frame: At 2 years ]

Central Contacts and Locations

Locations

Banner University Medical Center - Tucson

Recruiting

Tucson, Arizona, United States, 85719

Contacts

Site Public Contact

UACC-IIT@uacc.arizona.edu

Principal Investigator:

Krishna Rekha Moturi

University of Arizona Cancer Center-North Campus

Recruiting

Tucson, Arizona, United States, 85719

Contacts

Site Public Contact

UACC-IIT@uacc.arizona.edu

Principal Investigator:

Krishna Rekha Moturi

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

Recruiting

Jonesboro, Arkansas, United States, 72401

Contacts

Principal Investigator:

Muhammad Raza

Kaiser Permanente-Anaheim

Recruiting

Anaheim, California, United States, 92806

Contacts

Principal Investigator:

Ashraf R. Aziz

Kaiser Permanente-Baldwin Park

Recruiting

Baldwin Park, California, United States, 91706

Contacts

Principal Investigator:

Ashraf R. Aziz

Kaiser Permanente-Bellflower

Recruiting

Bellflower, California, United States, 90706

Contacts

Principal Investigator:

Ashraf R. Aziz

Marshall Cancer Center

Recruiting

Cameron Park, California, United States, 95682

Contacts

Principal Investigator:

Joseph M. Tuscano

Enloe Medical Center

Recruiting

Chico, California, United States, 95926

Contacts

Site Public Contact

530-332-4700

Principal Investigator:

Joseph M. Tuscano

UC Irvine Health Cancer Center-Newport

Recruiting

Costa Mesa, California, United States, 92627

Contacts

Site Public Contact

877-827-8839

Principal Investigator:

Catherine C. Coombs

City of Hope Comprehensive Cancer Center

Recruiting

Duarte, California, United States, 91010

Contacts

Principal Investigator:

Alexey V. Danilov

Kaiser Permanente-Fontana

Recruiting

Fontana, California, United States, 92335

Contacts

Principal Investigator:

Ashraf R. Aziz

Kaiser Permanente South Bay

Recruiting

Harbor City, California, United States, 90710

Contacts

Principal Investigator:

Ashraf R. Aziz

City of Hope Seacliff

Recruiting

Huntington Beach, California, United States, 92648

Contacts

Site Public Contact

626-256-4673

Principal Investigator:

Alexey V. Danilov

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Recruiting

Irvine, California, United States, 92612

Contacts

Site Public Contact

877-827-8839ucstudy@uci.edu

Principal Investigator:

Catherine C. Coombs

City of Hope at Irvine Lennar

Recruiting

Irvine, California, United States, 92618

Contacts

Site Public Contact

877-467-3411

Principal Investigator:

Alexey V. Danilov

Kaiser Permanente-Irvine

Recruiting

Irvine, California, United States, 92618

Contacts

Principal Investigator:

Ashraf R. Aziz

UCI Health Laguna Hills

Recruiting

Laguna Hills, California, United States, 92653

Contacts

Site Public Contact

877-827-8839ucstudy@uci.edu

Principal Investigator:

Catherine C. Coombs

City of Hope Antelope Valley

Recruiting

Lancaster, California, United States, 93534

Contacts

Principal Investigator:

Alexey V. Danilov

City of Hope at Long Beach Elm

Recruiting

Long Beach, California, United States, 90813

Contacts

Site Public Contact

877-467-3411

Principal Investigator:

Alexey V. Danilov

Kaiser Permanente Los Angeles Medical Center

Recruiting

Los Angeles, California, United States, 90027

Contacts

Principal Investigator:

Ashraf R. Aziz

Kaiser Permanente West Los Angeles

Recruiting

Los Angeles, California, United States, 90034

Contacts

Principal Investigator:

Ashraf R. Aziz

Fremont - Rideout Cancer Center

Recruiting

Marysville, California, United States, 95901

Contacts

Site Public Contact

530-749-4400

Principal Investigator:

Joseph M. Tuscano

City of Hope Newport Beach

Recruiting

Newport Beach, California, United States, 92660

Contacts

Site Public Contact

877-467-3411

Principal Investigator:

Alexey V. Danilov

Kaiser Permanente-Ontario

Recruiting

Ontario, California, United States, 91761

Contacts

Principal Investigator:

Ashraf R. Aziz

UC Irvine Health/Chao Family Comprehensive Cancer Center

Recruiting

Orange, California, United States, 92868

Contacts

Site Public Contact

877-827-8839ucstudy@uci.edu

Principal Investigator:

Catherine C. Coombs

Kaiser Permanente - Panorama City

Recruiting

Panorama City, California, United States, 91402

Contacts

Principal Investigator:

Ashraf R. Aziz

Kaiser Permanente-Riverside

Recruiting

Riverside, California, United States, 92505

Contacts

Principal Investigator:

Ashraf R. Aziz

University of California Davis Comprehensive Cancer Center

Recruiting

Sacramento, California, United States, 95817

Contacts

Site Public Contact

916-734-3089

Principal Investigator:

Joseph M. Tuscano

Kaiser Permanente-San Diego Zion

Recruiting

San Diego, California, United States, 92120

Contacts

Principal Investigator:

Ashraf R. Aziz

Kaiser Permanente-San Marcos

Recruiting

San Marcos, California, United States, 92078

Contacts

Principal Investigator:

Ashraf R. Aziz

City of Hope South Pasadena

Recruiting

South Pasadena, California, United States, 91030

Contacts

Principal Investigator:

Alexey V. Danilov

City of Hope South Bay

Recruiting

Torrance, California, United States, 90503

Contacts

Site Public Contact

877-467-3411

Principal Investigator:

Alexey V. Danilov

City of Hope Upland

Recruiting

Upland, California, United States, 91786

Contacts

Principal Investigator:

Alexey V. Danilov

Kaiser Permanente-Woodland Hills

Recruiting

Woodland Hills, California, United States, 91367

Contacts

Principal Investigator:

Ashraf R. Aziz

Grand Valley Oncology

Recruiting

Grand Junction, Colorado, United States, 81505

Contacts

Principal Investigator:

Jonathan D. King

Beebe South Coastal Health Campus

Recruiting

Millville, Delaware, United States, 19967

Contacts

Principal Investigator:

Gregory A. Masters

Helen F Graham Cancer Center

Recruiting

Newark, Delaware, United States, 19713

Contacts

Principal Investigator:

Gregory A. Masters

Medical Oncology Hematology Consultants PA

Recruiting

Newark, Delaware, United States, 19713

Contacts

Principal Investigator:

Gregory A. Masters

Beebe Health Campus

Recruiting

Rehoboth Beach, Delaware, United States, 19971

Contacts

Principal Investigator:

Gregory A. Masters

Sibley Memorial Hospital

Recruiting

Washington D.C., District of Columbia, United States, 20016

Contacts

Principal Investigator:

Nina D. Wagner-Johnston

Holy Cross Hospital

Recruiting

Fort Lauderdale, Florida, United States, 33308

Contacts

Site Public Contact

eileen.georgi@holy-cross.com

Principal Investigator:

Elie G. Dib

Saint Alphonsus Cancer Care Center-Boise

Recruiting

Boise, Idaho, United States, 83706

Contacts

Principal Investigator:

Elie G. Dib

Saint Alphonsus Cancer Care Center-Caldwell

Recruiting

Caldwell, Idaho, United States, 83605

Contacts

Principal Investigator:

Elie G. Dib

Kootenai Health - Coeur d'Alene

Recruiting

Coeur d'Alene, Idaho, United States, 83814

Contacts

Principal Investigator:

John M. Schallenkamp

Saint Alphonsus Cancer Care Center-Nampa

Recruiting

Nampa, Idaho, United States, 83687

Contacts

Principal Investigator:

Elie G. Dib

Kootenai Clinic Cancer Services - Post Falls

Recruiting

Post Falls, Idaho, United States, 83854

Contacts

Principal Investigator:

John M. Schallenkamp

Kootenai Clinic Cancer Services - Sandpoint

Recruiting

Sandpoint, Idaho, United States, 83864

Contacts

Principal Investigator:

John M. Schallenkamp

Rush-Copley Medical Center

Recruiting

Aurora, Illinois, United States, 60504

Contacts

Principal Investigator:

Suparna Mantha

Northwestern University

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Principal Investigator:

Shuo Ma

University of Chicago Comprehensive Cancer Center

Recruiting

Chicago, Illinois, United States, 60637

Contacts

Principal Investigator:

Michael J. Thirman

Carle at The Riverfront

Recruiting

Danville, Illinois, United States, 61832

Contacts

Principal Investigator:

Suparna Mantha

Cancer Care Specialists of Illinois - Decatur

Recruiting

Decatur, Illinois, United States, 62526

Contacts

Principal Investigator:

Bryan A. Faller

Northwestern Medicine Cancer Center Kishwaukee

Recruiting

DeKalb, Illinois, United States, 60115

Contacts

Principal Investigator:

Robert M. Eisner

Carle Physician Group-Effingham

Recruiting

Effingham, Illinois, United States, 62401

Contacts

Principal Investigator:

Suparna Mantha

Crossroads Cancer Center

Recruiting

Effingham, Illinois, United States, 62401

Contacts

Principal Investigator:

Bryan A. Faller

Elmhurst Memorial Hospital

Recruiting

Elmhurst, Illinois, United States, 60126

Contacts

Site Public Contact

630-758-5460Jrohde@emhc.org

Principal Investigator:

Matthew Siegel

NorthShore University HealthSystem-Evanston Hospital

Recruiting

Evanston, Illinois, United States, 60201

Contacts

Site Public Contact

847-570-2109

Principal Investigator:

David L. Grinblatt

Northwestern Medicine Cancer Center Delnor

Recruiting

Geneva, Illinois, United States, 60134

Contacts

Principal Investigator:

Robert M. Eisner

NorthShore University HealthSystem-Glenbrook Hospital

Recruiting

Glenview, Illinois, United States, 60026

Contacts

Site Public Contact

847-570-2109

Principal Investigator:

David L. Grinblatt

Northwestern Medicine Glenview Outpatient Center

Recruiting

Glenview, Illinois, United States, 60026

Contacts

Site Public Contact

312-695-1102

Principal Investigator:

Shuo Ma

Northwestern Medicine Grayslake Outpatient Center

Recruiting

Grayslake, Illinois, United States, 60030

Contacts

Site Public Contact

312-695-1102

Principal Investigator:

Shuo Ma

Ingalls Memorial Hospital

Recruiting

Harvey, Illinois, United States, 60426

Contacts

Principal Investigator:

Ivy Abraham

NorthShore University HealthSystem-Highland Park Hospital

Recruiting

Highland Park, Illinois, United States, 60035

Contacts

Site Public Contact

847-570-2109

Principal Investigator:

David L. Grinblatt

Northwestern Medicine Lake Forest Hospital

Recruiting

Lake Forest, Illinois, United States, 60045

Contacts

Principal Investigator:

Shuo Ma

Carle Physician Group-Mattoon/Charleston

Recruiting

Mattoon, Illinois, United States, 61938

Contacts

Principal Investigator:

Suparna Mantha

Loyola University Medical Center

Recruiting

Maywood, Illinois, United States, 60153

Contacts

Site Public Contact

708-226-4357

Principal Investigator:

Patrick A. Hagen

SSM Health Good Samaritan

Recruiting

Mount Vernon, Illinois, United States, 62864

Contacts

Principal Investigator:

Jay W. Carlson

Edward Hospital/Cancer Center

Recruiting

Naperville, Illinois, United States, 60540

Contacts

Site Public Contact

630-646-6075

Principal Investigator:

Matthew Siegel

UC Comprehensive Cancer Center at Silver Cross

Recruiting

New Lenox, Illinois, United States, 60451

Contacts

Principal Investigator:

Michael J. Thirman

Cancer Care Center of O'Fallon

Recruiting

O'Fallon, Illinois, United States, 62269

Contacts

Principal Investigator:

Bryan A. Faller

University of Chicago Medicine-Orland Park

Recruiting

Orland Park, Illinois, United States, 60462

Contacts

Principal Investigator:

Michael J. Thirman

Edward Hospital/Cancer Center?Plainfield

Recruiting

Plainfield, Illinois, United States, 60585

Contacts

Principal Investigator:

Matthew Siegel

UW Health Carbone Cancer Center Rockford

Recruiting

Rockford, Illinois, United States, 61114

Contacts

Principal Investigator:

Fahrettin Covut

Southern Illinois University School of Medicine

Recruiting

Springfield, Illinois, United States, 62702

Contacts

Site Public Contact

217-545-7929

Principal Investigator:

Bryan A. Faller

Springfield Clinic

Recruiting

Springfield, Illinois, United States, 62702

Contacts

Site Public Contact

800-444-7541

Principal Investigator:

Bryan A. Faller

Carle Cancer Center

Recruiting

Urbana, Illinois, United States, 61801

Contacts

Principal Investigator:

Suparna Mantha

Northwestern Medicine Cancer Center Warrenville

Recruiting

Warrenville, Illinois, United States, 60555

Contacts

Principal Investigator:

Robert M. Eisner

Rush-Copley Healthcare Center

Recruiting

Yorkville, Illinois, United States, 60560

Contacts

Principal Investigator:

Suparna Mantha

UChicago Medicine Northwest Indiana

Recruiting

Crown Point, Indiana, United States, 46307

Contacts

Principal Investigator:

Michael J. Thirman

Indiana University/Melvin and Bren Simon Cancer Center

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

Site Public Contact

317-278-5632iutrials@iu.edu

Principal Investigator:

Rita Assi

Mary Greeley Medical Center

Recruiting

Ames, Iowa, United States, 50010

Contacts

Site Public Contact

515-956-4132

Principal Investigator:

Joseph J. Merchant

McFarland Clinic - Ames

Recruiting

Ames, Iowa, United States, 50010

Contacts

Principal Investigator:

Joseph J. Merchant

UI Health Care Mission Cancer and Blood - Ankeny Clinic

Recruiting

Ankeny, Iowa, United States, 50023

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Richard L. Deming

Physicians' Clinic of Iowa PC

Recruiting

Cedar Rapids, Iowa, United States, 52402

Contacts

Site Public Contact

319-297-2900

Principal Investigator:

Bharat Jenigiri

UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Recruiting

Clive, Iowa, United States, 50325

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Seema Harichand-Herdt

Iowa Methodist Medical Center

Recruiting

Des Moines, Iowa, United States, 50309

Contacts

Site Public Contact

515-241-6727

Principal Investigator:

Seema Harichand-Herdt

UI Health Care Mission Cancer and Blood - Des Moines Clinic

Recruiting

Des Moines, Iowa, United States, 50309

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Seema Harichand-Herdt

Broadlawns Medical Center

Recruiting

Des Moines, Iowa, United States, 50314

Contacts

Site Public Contact

515-282-2200

Principal Investigator:

Seema Harichand-Herdt

Mercy Medical Center - Des Moines

Recruiting

Des Moines, Iowa, United States, 50314

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Richard L. Deming

UI Health Care Mission Cancer and Blood - Laurel Clinic

Recruiting

Des Moines, Iowa, United States, 50314

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Seema Harichand-Herdt

McFarland Clinic - Trinity Cancer Center

Recruiting

Fort Dodge, Iowa, United States, 50501

Contacts

Site Public Contact

515-956-4132

Principal Investigator:

Joseph J. Merchant

McFarland Clinic - Marshalltown

Recruiting

Marshalltown, Iowa, United States, 50158

Contacts

Site Public Contact

515-956-4132

Principal Investigator:

Joseph J. Merchant

UI Health Care Mission Cancer and Blood - Waukee Clinic

Recruiting

Waukee, Iowa, United States, 50263

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Seema Harichand-Herdt

HaysMed

Recruiting

Hays, Kansas, United States, 67601

Contacts

Site Public Contact

785-623-5774

Principal Investigator:

Marc S. Hoffmann

University of Kansas Cancer Center

Recruiting

Kansas City, Kansas, United States, 66160

Contacts

Principal Investigator:

Marc S. Hoffmann

Lawrence Memorial Hospital

Recruiting

Lawrence, Kansas, United States, 66044

Contacts

Principal Investigator:

Marc S. Hoffmann

The University of Kansas Cancer Center - Olathe

Recruiting

Olathe, Kansas, United States, 66061

Contacts

Principal Investigator:

Marc S. Hoffmann

University of Kansas Cancer Center-Overland Park

Recruiting

Overland Park, Kansas, United States, 66210

Contacts

Principal Investigator:

Marc S. Hoffmann

Salina Regional Health Center

Recruiting

Salina, Kansas, United States, 67401

Contacts

Principal Investigator:

Marc S. Hoffmann

University of Kansas Health System Saint Francis Campus

Recruiting

Topeka, Kansas, United States, 66606

Contacts

Site Public Contact

785-295-8000

Principal Investigator:

Marc S. Hoffmann

University of Kansas Hospital-Westwood Cancer Center

Recruiting

Westwood, Kansas, United States, 66205

Contacts

Principal Investigator:

Marc S. Hoffmann

Harold Alfond Center for Cancer Care

Recruiting

Augusta, Maine, United States, 04330

Contacts

Site Public Contact

207-626-4855

Principal Investigator:

Andrew Rogers

MaineHealth Cancer Care and IV Therapy - Brunswick

Recruiting

Brunswick, Maine, United States, 04011

Contacts

Principal Investigator:

Andrew Rogers

Mid Coast Hospital

Recruiting

Brunswick, Maine, United States, 04011

Contacts

Principal Investigator:

Andrew Rogers

MaineHealth LincolnHealth Hospital

Recruiting

Damariscotta, Maine, United States, 04543

Contacts

Principal Investigator:

Andrew Rogers

MaineHealth Maine Medical Center - Portland

Recruiting

Portland, Maine, United States, 04102

Contacts

Principal Investigator:

Andrew Rogers

MaineHealth Maine Medical Center- Scarborough

Recruiting

Scarborough, Maine, United States, 04074

Contacts

Principal Investigator:

Andrew Rogers

MaineHealth Cancer Care and IV Therapy - South Portland

Recruiting

South Portland, Maine, United States, 04106

Contacts

Principal Investigator:

Andrew Rogers

Johns Hopkins University/Sidney Kimmel Cancer Center

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

Principal Investigator:

Nina D. Wagner-Johnston

Walter Reed National Military Medical Center

Recruiting

Bethesda, Maryland, United States, 20889-5600

Contacts

Site Public Contact

301-319-2100

Principal Investigator:

Christin Destefano

Tufts Medical Center

Recruiting

Boston, Massachusetts, United States, 02111

Contacts

Principal Investigator:

Andreas K. Klein

Dana-Farber Cancer Institute

Recruiting

Boston, Massachusetts, United States, 02215

Contacts

Site Public Contact

877-442-3324

Principal Investigator:

Inhye E. Ahn

Tufts Medical Center Cancer Center Stoneham

Recruiting

Stoneham, Massachusetts, United States, 02180

Contacts

Principal Investigator:

Andreas K. Klein

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Recruiting

Ann Arbor, Michigan, United States, 48106

Contacts

Principal Investigator:

Elie G. Dib

Bronson Battle Creek

Recruiting

Battle Creek, Michigan, United States, 49017

Contacts

Principal Investigator:

Kathleen Y. Butler

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Recruiting

Brighton, Michigan, United States, 48114

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health Medical Center - Brighton

Recruiting

Brighton, Michigan, United States, 48114

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Cancer Institute-Downriver

Recruiting

Brownstown, Michigan, United States, 48183

Contacts

Principal Investigator:

Haythem Y. Ali

Trinity Health IHA Medical Group Hematology Oncology - Canton

Recruiting

Canton, Michigan, United States, 48188

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health Medical Center - Canton

Recruiting

Canton, Michigan, United States, 48188

Contacts

Principal Investigator:

Elie G. Dib

Chelsea Hospital

Recruiting

Chelsea, Michigan, United States, 48118

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Recruiting

Chelsea, Michigan, United States, 48118

Contacts

Principal Investigator:

Elie G. Dib

Hematology Oncology Consultants-Clarkston

Recruiting

Clarkston, Michigan, United States, 48346

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Macomb Hospital-Clinton Township

Recruiting

Clinton Township, Michigan, United States, 48038

Contacts

Principal Investigator:

Haythem Y. Ali

Henry Ford Medical Center-Fairlane

Recruiting

Dearborn, Michigan, United States, 48126

Contacts

Principal Investigator:

Haythem Y. Ali

Henry Ford Hospital

Recruiting

Detroit, Michigan, United States, 48202

Contacts

Principal Investigator:

Haythem Y. Ali

Henry Ford Health Saint John Hospital

Recruiting

Detroit, Michigan, United States, 48236

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford River District Hospital

Recruiting

East China Township, Michigan, United States, 48054

Contacts

Principal Investigator:

Elie G. Dib

Cancer Hematology Centers - Flint

Recruiting

Flint, Michigan, United States, 48503

Contacts

Principal Investigator:

Elie G. Dib

Genesys Hurley Cancer Institute

Recruiting

Flint, Michigan, United States, 48503

Contacts

Principal Investigator:

Elie G. Dib

Hurley Medical Center

Recruiting

Flint, Michigan, United States, 48503

Contacts

Principal Investigator:

Elie G. Dib

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Recruiting

Grand Rapids, Michigan, United States, 49503

Contacts

Principal Investigator:

Kathleen Y. Butler

Henry Ford Saint John Hospital - Academic

Recruiting

Grosse Pointe Woods, Michigan, United States, 48236

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Saint John Hospital - Van Elslander

Recruiting

Grosse Pointe Woods, Michigan, United States, 48236

Contacts

Principal Investigator:

Elie G. Dib

Allegiance Health

Recruiting

Jackson, Michigan, United States, 49201

Contacts

Principal Investigator:

Haythem Y. Ali

Bronson Methodist Hospital

Recruiting

Kalamazoo, Michigan, United States, 49007

Contacts

Principal Investigator:

Kathleen Y. Butler

West Michigan Cancer Center

Recruiting

Kalamazoo, Michigan, United States, 49007

Contacts

Principal Investigator:

Kathleen Y. Butler

Beacon Kalamazoo Cancer Center

Recruiting

Kalamazoo, Michigan, United States, 49009

Contacts

Site Public Contact

574-647-7370

Principal Investigator:

Kathleen Y. Butler

University of Michigan Health - Sparrow Lansing

Recruiting

Lansing, Michigan, United States, 48912

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health Saint Mary Mercy Livonia Hospital

Recruiting

Livonia, Michigan, United States, 48154

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Saint John Hospital - Macomb Medical

Recruiting

Macomb, Michigan, United States, 48044

Contacts

Principal Investigator:

Elie G. Dib

Corewell Health Lakeland Hospitals - Niles Hospital

Recruiting

Niles, Michigan, United States, 49120

Contacts

Site Public Contact

616-391-1230

Principal Investigator:

Kathleen Y. Butler

Henry Ford Health Providence Novi Hospital

Recruiting

Novi, Michigan, United States, 48374

Contacts

Site Public Contact

248-849-5332kfife3@hfhs.org

Principal Investigator:

Haythem Y. Ali

Henry Ford Medical Center-Columbus

Recruiting

Novi, Michigan, United States, 48377

Contacts

Principal Investigator:

Haythem Y. Ali

Michigan Healthcare Professionals Pontiac

Recruiting

Pontiac, Michigan, United States, 48341

Contacts

Principal Investigator:

Elie G. Dib

Newland Medical Associates-Pontiac

Recruiting

Pontiac, Michigan, United States, 48341

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health Saint Joseph Mercy Oakland Hospital

Recruiting

Pontiac, Michigan, United States, 48341

Contacts

Principal Investigator:

Elie G. Dib

Corewell Health Reed City Hospital

Recruiting

Reed City, Michigan, United States, 49677

Contacts

Principal Investigator:

Kathleen Y. Butler

MyMichigan Medical Center Saginaw

Recruiting

Saginaw, Michigan, United States, 48601

Contacts

Principal Investigator:

Elie G. Dib

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Recruiting

Saint Joseph, Michigan, United States, 49085

Contacts

Principal Investigator:

Kathleen Y. Butler

Henry Ford Health Providence Southfield Hospital

Recruiting

Southfield, Michigan, United States, 48075

Contacts

Site Public Contact

248-849-5332kfife3@hfhs.org

Principal Investigator:

Adam M. Forman

MyMichigan Medical Center Tawas

Recruiting

Tawas City, Michigan, United States, 48764

Contacts

Principal Investigator:

Elie G. Dib

Munson Medical Center

Recruiting

Traverse City, Michigan, United States, 49684

Contacts

Principal Investigator:

Kathleen Y. Butler

Henry Ford Health Warren Hospital

Recruiting

Warren, Michigan, United States, 48093

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Warren Hospital - GLCMS

Recruiting

Warren, Michigan, United States, 48093

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford West Bloomfield Hospital

Recruiting

West Bloomfield, Michigan, United States, 48322

Contacts

Principal Investigator:

Haythem Y. Ali

Henry Ford Wyandotte Hospital

Recruiting

Wyandotte, Michigan, United States, 48192

Contacts

Site Public Contact

nhay@hfhs.org

Principal Investigator:

Haythem Y. Ali

University of Michigan Health - West

Recruiting

Wyoming, Michigan, United States, 49519

Contacts

Principal Investigator:

Kathleen Y. Butler

Huron Gastroenterology PC

Recruiting

Ypsilanti, Michigan, United States, 48106

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Recruiting

Ypsilanti, Michigan, United States, 48197

Contacts

Principal Investigator:

Elie G. Dib

Mercy Hospital

Recruiting

Coon Rapids, Minnesota, United States, 55433

Contacts

Principal Investigator:

David M. King

Essentia Health - Deer River Clinic

Recruiting

Deer River, Minnesota, United States, 56636

Contacts

Principal Investigator:

Bret E. Friday

Essentia Health Cancer Center

Recruiting

Duluth, Minnesota, United States, 55805

Contacts

Principal Investigator:

Bret E. Friday

Essentia Health Hibbing Clinic

Recruiting

Hibbing, Minnesota, United States, 55746

Contacts

Site Public Contact

218-786-3308

Principal Investigator:

Bret E. Friday

Saint John's Hospital - Healtheast

Recruiting

Maplewood, Minnesota, United States, 55109

Contacts

Principal Investigator:

David M. King

Minneapolis VA Medical Center

Recruiting

Minneapolis, Minnesota, United States, 55417

Contacts

Site Public Contact

612-467-2800

Principal Investigator:

George Scaria

Coborn Cancer Center at Saint Cloud Hospital

Recruiting

Saint Cloud, Minnesota, United States, 56303

Contacts

Principal Investigator:

Donald J. Jurgens

Park Nicollet Clinic - Saint Louis Park

Recruiting

Saint Louis Park, Minnesota, United States, 55416

Contacts

Principal Investigator:

David M. King

Essentia Health Sandstone

Recruiting

Sandstone, Minnesota, United States, 55072

Contacts

Principal Investigator:

Bret E. Friday

Saint Francis Regional Medical Center

Recruiting

Shakopee, Minnesota, United States, 55379

Contacts

Principal Investigator:

David M. King

Essentia Health Virginia Clinic

Recruiting

Virginia, Minnesota, United States, 55792

Contacts

Principal Investigator:

Bret E. Friday

Ridgeview Medical Center

Recruiting

Waconia, Minnesota, United States, 55387

Contacts

Principal Investigator:

David M. King

Baptist Memorial Hospital and Cancer Center-Golden Triangle

Recruiting

Columbus, Mississippi, United States, 39705

Contacts

Principal Investigator:

Muhammad Raza

Baptist Cancer Center-Grenada

Recruiting

Grenada, Mississippi, United States, 38901

Contacts

Principal Investigator:

Muhammad Raza

Baptist Memorial Hospital and Cancer Center-Union County

Recruiting

New Albany, Mississippi, United States, 38652

Contacts

Principal Investigator:

Muhammad Raza

Baptist Memorial Hospital and Cancer Center-Oxford

Recruiting

Oxford, Mississippi, United States, 38655

Contacts

Principal Investigator:

Muhammad Raza

Baptist Memorial Hospital and Cancer Center-Desoto

Recruiting

Southhaven, Mississippi, United States, 38671

Contacts

Principal Investigator:

Muhammad Raza

Saint Francis Medical Center

Recruiting

Cape Girardeau, Missouri, United States, 63703

Contacts

Site Public Contact

573-334-2230sfmc@sfmc.net

Principal Investigator:

Bryan A. Faller

Saint Luke's Hospital

Recruiting

Chesterfield, Missouri, United States, 63017

Contacts

Site Public Contact

314-205-6936

Principal Investigator:

Mark J. Fesler

Parkland Health Center - Farmington

Recruiting

Farmington, Missouri, United States, 63640

Contacts

Site Public Contact

314-996-5569

Principal Investigator:

Bryan A. Faller

University Health Truman Medical Center

Recruiting

Kansas City, Missouri, United States, 64108

Contacts

Site Public Contact

816-404-4375

Principal Investigator:

Marc S. Hoffmann

University of Kansas Cancer Center - Briarcliff

Recruiting

Kansas City, Missouri, United States, 64116

Contacts

Site Public Contact

913-588-3671

Principal Investigator:

Marc S. Hoffmann

Kansas City Veterans Affairs Medical Center

Recruiting

Kansas City, Missouri, United States, 64128

Contacts

Site Public Contact

800-525-1483

Principal Investigator:

Suman Kambhampati

University of Kansas Cancer Center - North

Recruiting

Kansas City, Missouri, United States, 64154

Contacts

Principal Investigator:

Marc S. Hoffmann

University of Kansas Cancer Center - Lee's Summit

Recruiting

Lee's Summit, Missouri, United States, 64064

Contacts

Principal Investigator:

Marc S. Hoffmann

Phelps Health Delbert Day Cancer Institute

Recruiting

Rolla, Missouri, United States, 65401

Contacts

Principal Investigator:

Jay W. Carlson

Sainte Genevieve County Memorial Hospital

Recruiting

Sainte Genevieve, Missouri, United States, 63670

Contacts

Site Public Contact

314-996-5569

Principal Investigator:

Bryan A. Faller

Mercy Hospital South

Recruiting

St Louis, Missouri, United States, 63128

Contacts

Principal Investigator:

Jay W. Carlson

Missouri Baptist Medical Center

Recruiting

St Louis, Missouri, United States, 63131

Contacts

Site Public Contact

314-996-5569

Principal Investigator:

Bryan A. Faller

Mercy Hospital Saint Louis

Recruiting

St Louis, Missouri, United States, 63141

Contacts

Site Public Contact

314-251-7066

Principal Investigator:

Jay W. Carlson

Missouri Baptist Sullivan Hospital

Recruiting

Sullivan, Missouri, United States, 63080

Contacts

Site Public Contact

314-996-5569

Principal Investigator:

Bryan A. Faller

Community Hospital of Anaconda

Recruiting

Anaconda, Montana, United States, 59711

Contacts

Principal Investigator:

John M. Schallenkamp

Billings Clinic Cancer Center

Recruiting

Billings, Montana, United States, 59101

Contacts

Principal Investigator:

John M. Schallenkamp

Bozeman Health Deaconess Hospital

Recruiting

Bozeman, Montana, United States, 59715

Contacts

Principal Investigator:

John M. Schallenkamp

Benefis Sletten Cancer Institute

Recruiting

Great Falls, Montana, United States, 59405

Contacts

Principal Investigator:

John M. Schallenkamp

Logan Health Medical Center

Recruiting

Kalispell, Montana, United States, 59901

Contacts

Principal Investigator:

John M. Schallenkamp

Community Medical Center

Recruiting

Missoula, Montana, United States, 59804

Contacts

Principal Investigator:

John M. Schallenkamp

OptumCare Cancer Care at Charleston

Recruiting

Las Vegas, Nevada, United States, 89102

Contacts

Principal Investigator:

John A. Ellerton

OptumCare Cancer Care at Fort Apache

Recruiting

Las Vegas, Nevada, United States, 89183

Contacts

Principal Investigator:

John A. Ellerton

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Recruiting

Lebanon, New Hampshire, United States, 03756

Contacts

Principal Investigator:

Frederick Lansigan

Memorial Sloan Kettering Basking Ridge

Recruiting

Basking Ridge, New Jersey, United States, 07920

Contacts

Site Public Contact

212-639-7592

Principal Investigator:

Efrat Luttwak

Cooper Hospital University Medical Center

Recruiting

Camden, New Jersey, United States, 08103

Contacts

Site Public Contact

856-325-6757

Principal Investigator:

Tulin Budak-Alpdogan

Jersey City Medical Center

Recruiting

Jersey City, New Jersey, United States, 07302

Contacts

Principal Investigator:

Joanna M. Rhodes

Monmouth Medical Center Southern Campus

Recruiting

Lakewood, New Jersey, United States, 08701

Contacts

Principal Investigator:

Joanna M. Rhodes

Monmouth Medical Center

Recruiting

Long Branch, New Jersey, United States, 07740

Contacts

Principal Investigator:

Joanna M. Rhodes

Memorial Sloan Kettering Monmouth

Recruiting

Middletown, New Jersey, United States, 07748

Contacts

Site Public Contact

212-639-7592

Principal Investigator:

Efrat Luttwak

Memorial Sloan Kettering Bergen

Recruiting

Montvale, New Jersey, United States, 07645

Contacts

Site Public Contact

212-639-7592

Principal Investigator:

Efrat Luttwak

Rutgers Cancer Institute of New Jersey

Recruiting

New Brunswick, New Jersey, United States, 08903

Contacts

Site Public Contact

732-235-7356

Principal Investigator:

Joanna M. Rhodes

Community Medical Center

Recruiting

Toms River, New Jersey, United States, 08755

Contacts

Principal Investigator:

Joanna M. Rhodes

MD Anderson Cancer Center at Cooper-Voorhees

Recruiting

Voorhees Township, New Jersey, United States, 08043

Contacts

Site Public Contact

856-325-6757

Principal Investigator:

Tulin Budak-Alpdogan

University of New Mexico Cancer Center

Recruiting

Albuquerque, New Mexico, United States, 87106

Contacts

Principal Investigator:

Leslie A. Andritsos

Memorial Medical Center-Las Cruces

Recruiting

Las Cruces, New Mexico, United States, 88011

Contacts

Principal Investigator:

Leslie A. Andritsos

Presbyterian Rust Medical Center/Jorgensen Cancer Center

Recruiting

Rio Rancho, New Mexico, United States, 87124

Contacts

Site Public Contact

505-559-6113WBurman@phs.org

Principal Investigator:

Leslie A. Andritsos

Hematology Oncology Associates of CNY at Camillus

Recruiting

Camillus, New York, United States, 13031

Contacts

Site Public Contact

315-472-7504

Principal Investigator:

Steven M. Duffy

Memorial Sloan Kettering Commack

Recruiting

Commack, New York, United States, 11725

Contacts

Site Public Contact

212-639-7592

Principal Investigator:

Efrat Luttwak

Hematology Oncology Associates of Central New York-East Syracuse

Recruiting

East Syracuse, New York, United States, 13057

Contacts

Site Public Contact

315-472-7504

Principal Investigator:

Steven M. Duffy

Glens Falls Hospital

Recruiting

Glens Falls, New York, United States, 12801

Contacts

Site Public Contact

518-926-6700

Principal Investigator:

Christopher R. Mason

Memorial Sloan Kettering Westchester

Recruiting

Harrison, New York, United States, 10604

Contacts

Site Public Contact

212-639-7592

Principal Investigator:

Efrat Luttwak

Memorial Sloan Kettering Cancer Center

Recruiting

New York, New York, United States, 10065

Contacts

Site Public Contact

212-639-7592

Principal Investigator:

Efrat Luttwak

Upstate Cancer Center at Oswego

Recruiting

Oswego, New York, United States, 13126

Contacts

Principal Investigator:

Krishna Ghimire

University of Rochester

Recruiting

Rochester, New York, United States, 14642

Contacts

Site Public Contact

585-275-5830

Principal Investigator:

Paul M. Barr

State University of New York Upstate Medical University

Recruiting

Syracuse, New York, United States, 13210

Contacts

Site Public Contact

315-464-5476

Principal Investigator:

Krishna Ghimire

SUNY Upstate Medical Center-Community Campus

Recruiting

Syracuse, New York, United States, 13215

Contacts

Site Public Contact

315-464-5476

Principal Investigator:

Krishna Ghimire

Memorial Sloan Kettering Nassau

Recruiting

Uniondale, New York, United States, 11553

Contacts

Site Public Contact

212-639-7592

Principal Investigator:

Efrat Luttwak

Upstate Cancer Center at Verona

Recruiting

Verona, New York, United States, 13478

Contacts

Principal Investigator:

Krishna Ghimire

Wilmot Cancer Institute at Webster

Recruiting

Webster, New York, United States, 14580

Contacts

Principal Investigator:

Paul M. Barr

UNC Lineberger Comprehensive Cancer Center

Recruiting

Chapel Hill, North Carolina, United States, 27599

Contacts

Principal Investigator:

Deborah M. Stephens

Southeastern Medical Oncology Center-Clinton

Recruiting

Clinton, North Carolina, United States, 28328

Contacts

Principal Investigator:

Samer S. Kasbari

Duke University Medical Center

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Site Public Contact

888-275-3853

Principal Investigator:

Danielle M. Brander

Southeastern Medical Oncology Center-Goldsboro

Recruiting

Goldsboro, North Carolina, United States, 27534

Contacts

Principal Investigator:

Samer S. Kasbari

East Carolina University

Recruiting

Greenville, North Carolina, United States, 27834

Contacts

Principal Investigator:

Darla K. Liles

Margaret R Pardee Memorial Hospital

Recruiting

Hendersonville, North Carolina, United States, 28791

Contacts

Principal Investigator:

John K. Hill

University of North Carolina-Hillsborough Campus

Recruiting

Hillsborough, North Carolina, United States, 27278

Contacts

Principal Investigator:

Deborah M. Stephens

Southeastern Medical Oncology Center-Jacksonville

Recruiting

Jacksonville, North Carolina, United States, 28546

Contacts

Principal Investigator:

Samer S. Kasbari

ECU Health Oncology Kinston

Recruiting

Kinston, North Carolina, United States, 28501

Contacts

Principal Investigator:

Misbah U. Qadir

Cleveland Clinic Cancer Center/Fairview Hospital

Recruiting

Cleveland, Ohio, United States, 44111

Contacts

Principal Investigator:

Brian T. Hill

Cleveland Clinic Foundation

Recruiting

Cleveland, Ohio, United States, 44195

Contacts

Principal Investigator:

Brian T. Hill

Ohio State University Comprehensive Cancer Center

Recruiting

Columbus, Ohio, United States, 43210

Contacts

Principal Investigator:

Seema A. Bhat

Hillcrest Hospital Cancer Center

Recruiting

Mayfield Heights, Ohio, United States, 44124

Contacts

Principal Investigator:

Brian T. Hill

ProMedica Flower Hospital

Recruiting

Sylvania, Ohio, United States, 43560

Contacts

Principal Investigator:

Abhijit B. Saste

University of Oklahoma Health Sciences Center

Recruiting

Oklahoma City, Oklahoma, United States, 73104

Contacts

Principal Investigator:

Mohamad Khawandanah

Saint Charles Health System

Recruiting

Bend, Oregon, United States, 97701

Contacts

Principal Investigator:

Charles W. Drescher

Saint Alphonsus Cancer Care Center-Ontario

Recruiting

Ontario, Oregon, United States, 97914

Contacts

Principal Investigator:

Elie G. Dib

Providence Portland Medical Center

Recruiting

Portland, Oregon, United States, 97213

Contacts

Principal Investigator:

Charles W. Drescher

Providence Saint Vincent Medical Center

Recruiting

Portland, Oregon, United States, 97225

Contacts

Principal Investigator:

Charles W. Drescher

Lehigh Valley Hospital-Cedar Crest

Recruiting

Allentown, Pennsylvania, United States, 18103

Contacts

Principal Investigator:

Elie G. Dib

Lehigh Valley Hospital - Muhlenberg

Recruiting

Bethlehem, Pennsylvania, United States, 18017

Contacts

Principal Investigator:

Elie G. Dib

Geisinger Medical Center

Recruiting

Danville, Pennsylvania, United States, 17822

Contacts

Principal Investigator:

Joseph J. Vadakara

Thomas Jefferson University Hospital

Recruiting

Philadelphia, Pennsylvania, United States, 19107

Contacts

Principal Investigator:

Gina M. Keiffer

Jefferson Torresdale Hospital

Recruiting

Philadelphia, Pennsylvania, United States, 19114

Contacts

Principal Investigator:

Gina M. Keiffer

Geisinger Wyoming Valley/Henry Cancer Center

Recruiting

Wilkes-Barre, Pennsylvania, United States, 18711

Contacts

Principal Investigator:

Joseph J. Vadakara

Asplundh Cancer Pavilion

Recruiting

Willow Grove, Pennsylvania, United States, 19090

Contacts

Principal Investigator:

Gina M. Keiffer

Prisma Health Cancer Institute - Spartanburg

Recruiting

Boiling Springs, South Carolina, United States, 29316

Contacts

Principal Investigator:

Suzanne R. Fanning

Ralph H Johnson VA Medical Center

Recruiting

Charleston, South Carolina, United States, 29401

Contacts

Principal Investigator:

Oleksandra Lupak

Medical University of South Carolina

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Principal Investigator:

Brian T. Hess

Prisma Health Cancer Institute - Easley

Recruiting

Easley, South Carolina, United States, 29640

Contacts

Principal Investigator:

Suzanne R. Fanning

Prisma Health Cancer Institute - Butternut

Recruiting

Greenville, South Carolina, United States, 29605

Contacts

Principal Investigator:

Suzanne R. Fanning

Prisma Health Cancer Institute - Faris

Recruiting

Greenville, South Carolina, United States, 29605

Contacts

Principal Investigator:

Suzanne R. Fanning

Prisma Health Cancer Institute - Eastside

Recruiting

Greenville, South Carolina, United States, 29615

Contacts

Principal Investigator:

Suzanne R. Fanning

Prisma Health Cancer Institute - Greer

Recruiting

Greer, South Carolina, United States, 29650

Contacts

Principal Investigator:

Suzanne R. Fanning

Prisma Health Cancer Institute - Seneca

Recruiting

Seneca, South Carolina, United States, 29672

Contacts

Principal Investigator:

Suzanne R. Fanning

Baptist Memorial Hospital and Cancer Center-Collierville

Recruiting

Collierville, Tennessee, United States, 38017

Contacts

Principal Investigator:

Muhammad Raza

Ballad Health Cancer Care - Kingsport

Recruiting

Kingsport, Tennessee, United States, 37660

Contacts

Principal Investigator:

Asheesh Shipstone

Baptist Memorial Hospital and Cancer Center-Memphis

Recruiting

Memphis, Tennessee, United States, 38120

Contacts

Principal Investigator:

Muhammad Raza

Huntsman Cancer Institute/University of Utah

Recruiting

Salt Lake City, Utah, United States, 84112

Contacts

Principal Investigator:

Lindsey Fitzgerald

Ballad Health Cancer Care - Bristol

Recruiting

Bristol, Virginia, United States, 24201

Contacts

Principal Investigator:

Asheesh Shipstone

Ballad Health Cancer Care - Norton

Recruiting

Norton, Virginia, United States, 24273

Contacts

Principal Investigator:

Asheesh Shipstone

VCU Massey Cancer Center at Stony Point

Recruiting

Richmond, Virginia, United States, 23235

Contacts

Site Public Contact

ctoclinops@vcu.edu

Principal Investigator:

Bharadhwaj Kolipakkam

VCU Massey Comprehensive Cancer Center

Recruiting

Richmond, Virginia, United States, 23298

Contacts

Principal Investigator:

Bharadhwaj Kolipakkam

FHCC Overlake

Recruiting

Bellevue, Washington, United States, 98004

Contacts

Site Public Contact

425-454-2148

Principal Investigator:

Jason Comer

Swedish Cancer Institute-Edmonds

Recruiting

Edmonds, Washington, United States, 98026

Contacts

Principal Investigator:

Charles W. Drescher

Swedish Cancer Institute-Issaquah

Recruiting

Issaquah, Washington, United States, 98029

Contacts

Principal Investigator:

Charles W. Drescher

Kadlec Clinic Hematology and Oncology

Recruiting

Kennewick, Washington, United States, 99336

Contacts

Principal Investigator:

Charles W. Drescher

FHCC at EvergreenHealth

Recruiting

Kirkland, Washington, United States, 98034

Contacts

Site Public Contact

425-899-6000

Principal Investigator:

Prakash Varadarajan

Fred Hutchinson Cancer Center

Recruiting

Seattle, Washington, United States, 98109

Contacts

Site Public Contact

800-804-8824

Principal Investigator:

Mazyar Shadman

Swedish Medical Center-First Hill

Recruiting

Seattle, Washington, United States, 98122

Contacts

Principal Investigator:

Charles W. Drescher

FHCC at Northwest Hospital

Recruiting

Seattle, Washington, United States, 98133

Contacts

Site Public Contact

206-606-5800

Principal Investigator:

Paul S. Martin

University of Washington Medical Center - Montlake

Recruiting

Seattle, Washington, United States, 98195

Contacts

Site Public Contact

800-804-8824

Principal Investigator:

Mazyar Shadman

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Recruiting

Yakima, Washington, United States, 98902

Contacts

Principal Investigator:

John A. Ellerton

Aspirus Cancer Care-Antigo-Volm Cancer Center

Recruiting

Antigo, Wisconsin, United States, 54409

Contacts

Principal Investigator:

Andrew J. Huang

Duluth Clinic Ashland

Recruiting

Ashland, Wisconsin, United States, 54806

Contacts

Principal Investigator:

Bret E. Friday

Marshfield Medical Center-EC Cancer Center

Recruiting

Eau Claire, Wisconsin, United States, 54701

Contacts

Principal Investigator:

Chady A. Leon

Bellin Memorial Hospital

Recruiting

Green Bay, Wisconsin, United States, 54301

Contacts

Site Public Contact

920-435-8326

Principal Investigator:

Srinandan Guntupalli

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Recruiting

Madison, Wisconsin, United States, 53718

Contacts

Principal Investigator:

Priyanka Pophali

University of Wisconsin Carbone Cancer Center - University Hospital

Recruiting

Madison, Wisconsin, United States, 53792

Contacts

Principal Investigator:

Priyanka Pophali

Marshfield Medical Center-Marshfield

Recruiting

Marshfield, Wisconsin, United States, 54449

Contacts

Principal Investigator:

Chady A. Leon

Aspirus Medford Hospital

Recruiting

Medford, Wisconsin, United States, 54451

Contacts

Principal Investigator:

Andrew J. Huang

Marshfield Medical Center - Minocqua

Recruiting

Minocqua, Wisconsin, United States, 54548

Contacts

Principal Investigator:

Chady A. Leon

Cancer Center of Western Wisconsin

Recruiting

New Richmond, Wisconsin, United States, 54017

Contacts

Principal Investigator:

David M. King

Aspirus Cancer Care-Rhinelander-James Beck Cancer Center

Recruiting

Rhinelander, Wisconsin, United States, 54501

Contacts

Principal Investigator:

Andrew J. Huang

Marshfield Medical Center-Rice Lake

Recruiting

Rice Lake, Wisconsin, United States, 54868

Contacts

Principal Investigator:

Chady A. Leon

Aspirus Cancer Care - Stevens Point

Recruiting

Stevens Point, Wisconsin, United States, 54481

Contacts

Principal Investigator:

Andrew J. Huang

Marshfield Medical Center-River Region at Stevens Point

Recruiting

Stevens Point, Wisconsin, United States, 54482

Contacts

Principal Investigator:

Chady A. Leon

Aspirus Cancer Care-Wausau

Recruiting

Wausau, Wisconsin, United States, 54401

Contacts

Site Public Contact

877-405-6866

Principal Investigator:

Andrew J. Huang

Marshfield Medical Center - Weston

Recruiting

Weston, Wisconsin, United States, 54476

Contacts

Principal Investigator:

Chady A. Leon

Aspirus Cancer Care - Wisconsin Rapids

Recruiting

Wisconsin Rapids, Wisconsin, United States, 54494

Contacts

Site Public Contact

715-422-7718

Principal Investigator:

Andrew J. Huang

BCCA-Vancouver Cancer Centre

Recruiting

Vancouver, British Columbia, Canada, V5Z 4E6

Contacts

Site Public Contact

888-939-3333

Principal Investigator:

Alina S. Gerrie

CancerCare Manitoba

Recruiting

Winnipeg, Manitoba, Canada, R3E 0V9

Contacts

Principal Investigator:

Versha Banerji

Atlantic Health Sciences Corporation-Saint John Regional Hospital

Recruiting

Saint John, New Brunswick, Canada, E2L 4L2

Contacts

Site Public Contact

506-648-6890

Principal Investigator:

Alfonso Rivera Duarte

Jewish General Hospital

Recruiting

Montreal, Quebec, Canada, H3T 1E2

Contacts

Site Public Contact

514-340-8222

Principal Investigator:

Tanya Skamene

More Information

Sponsor

National Cancer Institute (NCI)

Last update posted

Sep 10, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-11. This information was provided to ClinicalTrials.gov by National Cancer Institute (NCI) on 2026-09-10.