Recruiting

Cardiovascular Magnetic Resonance

Sponsor:

Dipan Shah

Code:

NCT04281823

Conditions

Cardiovascular Diseases

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Interventions

Cardiovascular Magnetic Resonance

Study Details

Brief summary:

While advancements in cardiac magnetic resonance (CMR) have improved image quality, it is unclear how these improvements are connected to the clinical evaluation of individuals with cardiovascular disease. The aim of this large prospective registry revolves around 4 key principles: 1) utilize CMR to gain additional pathophysiologic insights into cardiovascular disease, 2) understand how CMR compares to alternative cardiovascular diagnostic modalities, 3) determine how CMR affects clinical management decisions, and 4) establish a link between CMR findings and long term prognosis in patients with known or suspected cardiovascular disease. The ultimate aim is to utilize CMR to improve patient outcomes.

CMR techniques to be studies include function, fibrosis, and flow. Focus areas include valvular heart disease, ischemic heart disease, cardiomyopathies, and vascular disease.

Conditions

Cardiovascular Diseases

Study ID

NCT04281823

Start date

Apr 1, 2008

Status verified date

Apr, 2026

Completion date

Apr 1, 2058

Anticipated

Primary completion date

Apr 1, 2058

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • All patients presenting to the Houston Methodist CMR Laboratory with known or suspected cardiovascular disease.

Exclusion Criteria:

  • Unable to provide informed consent

Study Design

Enrollment

100000 participants

Anticipated

Interventions and Outcome Measures

Arms

Cardiovascular Magnetic Resonance

All patients who present to the Houston Methodist CMR Laboratory

Interventions

Cardiovascular Magnetic Resonance

Patients will undergo various CMR techniques designed to assess cardiovascular structure and function, tissue characteristics, and flow.

Primary outcome measure

  • Mortality [ Time Frame: Through study completion, an average of once a year, up to 20 years ]
  • Heart Failure [ Time Frame: Through study completion, an average of once a year, up to 20 years ]
  • Heart and/or Lung Transplantation [ Time Frame: Through study completion, an average of once a year, up to 20 years ]
  • Left Ventricular and/or Right Ventricular Assist Device Implantation [ Time Frame: Through study completion, an average of once a year, up to 20 years ]

Central Contacts and Locations

Central contacts

Rachel Kronman-Gross, BS

7134416539rkronman-gross@houstonmethodist.org

Mohamad Ghosn, PhD

7134419837mghosn@houstonmethodist.org

Locations

Houston Methodist Hospital

Recruiting

Houston, Texas, United States, 77030

Contacts

Rachel Kronman-Gross, BS

713-441-6539rkronman-gross@houstonmethodist.org

Mohamad Ghosn, PhD

7134419837mghosn@houstonmethodist.org

Principal Investigator:

Dipan Shah, MD

More Information

Sponsor

Dipan Shah

Last update posted

Apr 20, 2026

Last verified

Apr, 2026

Keywords

  • Cardiovascular Disease
  • Cardiac Magnetic Resonance
  • Myocardial Fibrosis
  • Valvular Heart Disease
  • Ischemic Heart Disease
  • Cardiomyopathy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Dipan Shah on 2026-04-20.