Recruiting

Observational Study

Sponsor:

Massachusetts General Hospital

Code:

NCT04286308

Conditions

Parkinson Disease

Essential Tremor

Dystonia

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

electrophysiological data collection

Study Details

Brief summary:

In this research study the researchers want to learn more about brain activity related to speech perception and production.

Conditions

Parkinson Disease

Essential Tremor

Dystonia

Study ID

NCT04286308

Start date

Oct 1, 2020

Status verified date

Jan, 2026

Completion date

Feb, 2027

Anticipated

Primary completion date

Feb, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Subjects scheduled for DBS implantation, as determined by the clinical multidisciplinary movement disorders board with definitive diagnosis of Parkinson's disease, essential tremor or dystonia.
2. Subjects able to provide informed consent and comply with task instructions.
3. Subjects 18-85 years old

Exclusion Criteria:

1. Subjects with reported hearing loss.
2. Non-English-speaking subjects

Study Design

Enrollment

80 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Brain signal data collection

Brain signal data collection at the time of deep brain stimulation (DBS) surgery.

Interventions

electrophysiological data collection

Electrophysiological data collection at the time of DBS surgery.

Primary outcome measure

  • The number of subjects providing the interpretable speech related electrophysiological data collection. [ Time Frame: Duration of single DBS surgery ]

Central Contacts and Locations

Central contacts

Mark Richardson, MD, PhD

617-726-8849mark.richardson@mgh.harvard.edu

Erin Donahue, PhD

ekdonahue@mgh.harvard.edu

Locations

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Robert M Richardson, MD PhD

617-726-8849mark.richardson@mgh.harvard.edu

Erin Donahue, PhD

ekdonahue@mgh.harvard.edu

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Mar 25, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2026-03-25.