Recruiting

Sevoflurane vs. Propofol

Sponsor:

State University of New York - Downstate Medical Center

Code:

NCT04289090

Conditions

Percentage of Change in ONSD During Anesthesia With Sevoflurane Versus Propofol in Two Groups of Patients

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Sevoflurane Inhalant Product

Propofol 10 MG/ML

Study Details

Brief summary:

We will prospectively compare change in ONSD during anesthesia with sevoflurane-only versus anesthesia with propofol-only in two groups of patients undergoing urologic and gynecologic surgery in the steep Trendelenburg position. We hypothesize that there will be a significant decrease in the size of ONSD during transition from sevoflurane-only anesthesia to propofol-only anesthesia.

Conditions

Percentage of Change in ONSD During Anesthesia With Sevoflurane Versus Propofol in Two Groups of Patients

Study ID

NCT04289090

Start date

Jan 14, 2020

Status verified date

Feb, 2020

Completion date

Jan 17, 2022

Anticipated

Primary completion date

Jan 17, 2022

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

All patients scheduled to undergo surgery in the steep Trendelenburg position at SUNY Downstate Medical Center.

Exclusion Criteria:

< 18 years old Pregnancy Pre-existing eye disease Prior ophthalmic surgery Inability to tolerate steep Trendelenburg position Patient refusal

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Group A

Group A will begin anesthesia maintenance with sevoflurane-only, then will be switched after 30 minutes to anesthesia with propofol-only.

experimental: Group B

Group B will begin anesthesia with propofol-only then will be switched to sevoflurane-only.

Interventions

Sevoflurane Inhalant Product

This study will perform intra-operative sonographic ONSD measurements in order to compare the change in ONSD during transition from inhalational maintenance anesthesia (using sevoflurane) to total intravenous anesthesia (TIVA) using propofol.

Propofol 10 MG/ML

This study will perform intra-operative sonographic ONSD measurements in order to compare the change in ONSD during transition from inhalational maintenance anesthesia (using sevoflurane) to total intravenous anesthesia (TIVA) using propofol.

Primary outcome measure

  • Sevoflurane Versus Propofol on Optic Nerve Sheath Diameter During Anesthesia in Steep Trendelenburg Position [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Gina Subtirelu, MD

516-241-5038gina.subtirelu@downstate.edu

Mauricia C Victor, MS,MPH

718-270-1937mauricia.victor@downstate.edu

Locations

SUNY Downstate Medical Center

Recruiting

Brooklyn, New York, United States, 11203-2098

More Information

Sponsor

State University of New York - Downstate Medical Center

Last update posted

Feb 28, 2020

Last verified

Feb, 2020

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by State University of New York - Downstate Medical Center on 2020-02-28.