Recruiting

Creatine & Caffeine

Sponsor:

University of Regina

Code:

NCT04290819

Conditions

Performance Enhancing Product Use

Eligibility Criteria

Sex: All

Age: 18 - 39

Healthy Volunteers: Accepted

Interventions

Creatine Monohydrate

Creatine Monohydrate and Caffeine

Caffeine

Placebo

Study Details

Brief summary:

To determine if creatine and caffeine can be co-supplemented without inhibiting the effects of creatine.

Conditions

Performance Enhancing Product Use

Study ID

NCT04290819

Start date

Feb 15, 2019

Status verified date

Feb, 2020

Completion date

Sep 1, 2020

Anticipated

Primary completion date

May 31, 2020

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 39

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Male or Female ages 18-39
  • Resistance training for minimum of 6 months 3/week.

Exclusion Criteria:

  • Creatine supplementation within last 3 months
  • Taking medications that affect muscle biology
  • Have a disease that affects muscle biology
  • Pre existing liver or kidney abnormalities
  • Plan to travel for greater then 1 week during the study where you have NO access to fitness facility.
  • Fail Par-Q and are unable to receive doctors clearance

Study Design

Enrollment

36 participants

Anticipated

Allocation

Randomized

Intervention Model

Factorial

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Resistance Training with Creatine Monohydrate

Participants will go through a 6 week resistance training program (unsupervised), at the facility of their choice. They will be given a program to follow with a 2 day on one day rest split routine as follows: Chest and biceps, legs and core, rest, back and triceps, shoulders and core, rest. This cycle will repeat for the 6 week program.

experimental: Resistance Training with Caffeine

Participants will go through a 6 week resistance training program (unsupervised), at the facility of their choice. They will be given a program to follow with a 2 day on one day rest split routine as follows: Chest and biceps, legs and core, rest, back and triceps, shoulders and core, rest. This cycle will repeat for the 6 week program.

experimental: Resistance Training with Caffeine and Creatine Monohydrate

Participants will go through a 6 week resistance training program (unsupervised), at the facility of their choice. They will be given a program to follow with a 2 day on one day rest split routine as follows: Chest and biceps, legs and core, rest, back and triceps, shoulders and core, rest. This cycle will repeat for the 6 week program.

placebo comparator: Resistance Training with Placebo

Participants will go through a 6 week resistance training program (unsupervised), at the facility of their choice. They will be given a program to follow with a 2 day on one day rest split routine as follows: Chest and biceps, legs and core, rest, back and triceps, shoulders and core, rest. This cycle will repeat for the 6 week program.

Interventions

Creatine Monohydrate

0.1g/kg of body weight (pre measured creatine) and 3mg/kg of body weight (pre measured micronized cellulose powder-caffeine placebo) self administered 1 hr prior to working out mixed in water.

Creatine Monohydrate and Caffeine

0.1g/kg body weight (pre measured creatine) and 3mg/kg body weight (pre measured caffeine) self administered 1hr prior to working out mixed in water.

Caffeine

3mg/kg of body weight (pre measured caffeine) and 0.1g/kg of bodyweight (pre measured maltodextrin- creatine placebo) self administered 1 hr prior to working out mixed in water.

Placebo

0.1g/kg of body weight (pre measured maltodextrin) and 3mg/kg of body weight (pre measured micronized cellulose powder) self administered 1 hr prior to working out mixed in water.

Primary outcome measure

  • Muscle strength using a standard plate loaded leg press and chest press machine [ Time Frame: 6 weeks ]
  • Hypertrophy [ Time Frame: 6 weeks ]
  • Muscle endurance using a standard plate loaded leg press and chest press machine [ Time Frame: 6 weeks ]
  • Body Composition using a Bod Pod [ Time Frame: 6 weeks ]

Central Contacts and Locations

Central contacts

Darren G Candow, PhD

209-0280darren.candow@uregina.ca

Avery R Pakulak, BKin

216-2904pakulaka@uregina.ca

Locations

University of Regina

Recruiting

Regina, Saskatchewan, Canada, S4S4H4

Contacts

Darren G Candow, PhD

3062090280Darren.Candow@uregina.ca

Principal Investigator:

Darren G Candow, PhD

More Information

Sponsor

University of Regina

Last update posted

Mar 2, 2020

Last verified

Feb, 2020

Keywords

  • Muscle Endurance
  • Strength
  • Hypertrophy
  • Resistance Training
  • Creatine
  • Caffeine

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Regina on 2020-03-02.