Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT04291651

Conditions

Pancreatic Cyst

Pancreatic Neoplasms

Pancreatic Cancer

Pancreatic Diseases

Pancreatic Intraductal Papillary Mucinous Neoplasm

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Survey

Study Details

Brief summary:

Pancreatic cysts are found incidentally on 15-50% of CT and MRIs for all indications and their prevalence is increasing. Many of these cysts may be precursors to pancreatic cancer, and thus pose a substantial risk, however, the vast majority are benign. Increased detection of pancreatic cysts provides an opportunity to diagnose pancreatic malignancy at an early, curable stage yet also increases the potential to over-treat clinically insignificant lesions. This presents a clinical challenge to prevent unnecessary resection of indolent disease, with associated risks of infections, bleeding, diabetes, and costly disability. Unfortunately, there is little information on the epidemiology and natural history of pancreatic cysts to help guide management.

Conditions

Pancreatic Cyst

Pancreatic Neoplasms

Pancreatic Cancer

Pancreatic Diseases

Pancreatic Intraductal Papillary Mucinous Neoplasm

Study ID

NCT04291651

Start date

Oct 8, 2019

Status verified date

Sep, 2025

Completion date

Jan 1, 2030

Anticipated

Primary completion date

Jan 1, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • The inclusion criteria for this study are intentionally broad. Eligible patients for prospective enrollment will include
  • Adults ≥ 30 years of age
  • Have a radiographic or endoscopic diagnosis of at least one pancreatic cysts regardless of treatment status,
  • No history of pancreatic cancer,
  • Can speak and read English,
  • Have access to a computer or mobile device (\~95% of U.S. population); and
  • Are able to complete an electronic informed consent.

Exclusion Criteria:

  • Patients who don't speak English,
  • Don't have access to a computer or mobile device; or
  • Patients who have a cancer diagnosis.

Study Design

Enrollment

4000 participants

Anticipated

Interventions and Outcome Measures

Arms

Retrospective

The registry will be populated with a retrospective cohort of patients previously identified as having pancreatic cysts.

Prospective

The prospectively enrolled patients in this study are the primary population of interest.

Interventions

Survey

There are no study-specific interventions, as this is a prospective registry. However, patients will be asked to complete approximately 1-2 hours worth of surveys on things such as demographics, medical and surgical history, and pancreatic cyst-specific questionnaires.

Primary outcome measure

  • Cancer [ Time Frame: 1-10 years ]
  • Indolency [ Time Frame: 1-10 years ]

Central Contacts and Locations

Central contacts

Charysa Santos, BS

415-514-6914Charysa.Santos@ucsf.edu

Kimberly S Kirkwood, MD

415-502-5577kim.kirkwood@ucsf.edu

Locations

University of California, San Francisco

Recruiting

San Francisco, California, United States, 94143

Contacts

Charysa Santos, BS

415-514-6914Charysa.Santos@ucsf.edu

M.D.

877-827-3222cancertrials@ucsf.edu

Principal Investigator:

Kimberly Kirkwood, MD

More Information

Sponsor

University of California, San Francisco

Last update posted

Sep 18, 2025

Last verified

Sep, 2025

Keywords

  • Pancreatic Cyst
  • Pancreatic Cystic Lesion
  • Pancreatic Cancer
  • Intraductal Papillary Mucinous Neoplasm
  • Serous Cystadenoma
  • Mucinous Cystic Neoplasm
  • Cancer Epidemiology
  • Early Detection Research

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2025-09-18.