Recruiting

Mitochondria Dysfunction

Sponsor:

University of Washington

Code:

NCT04300608

Conditions

Parkinson Disease, Mitochondrial

Eligibility Criteria

Sex: All

Age: 65 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.

Conditions

Parkinson Disease, Mitochondrial

Study ID

NCT04300608

Start date

Feb 24, 2020

Status verified date

Nov, 2020

Completion date

Nov, 2021

Anticipated

Primary completion date

Jul, 2021

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 65 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 65-85 years.
  • Ability to attend a 3-hour study visit in Seattle, WA.
  • Ability to read and speak English.
  • Hoehn \& Yahr Stage 2-3. (bilateral disease, not severely disabled.)

Exclusion Criteria:

  • Any contra-indication to magnetic resonance imaging
  • A history of epilepsy, stroke, brain surgery, or structural brain disease.
  • The presence of other serious illnesses
  • Current or recent enrollment in a clinical trial involving an investigational product or device.
  • Supplementation with NAD, nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and other nutraceuticals designed to target NAD for 30 days prior to baseline study visit.
  • Current drug or alcohol use or dependence.
  • Inability/unwillingness to provide informed consent. (e.g. diagnosis of dementia, confusion about study goals or participation.)
  • Acute infection (e.g. upper respiratory, dermal) in the previous 30 days.
  • Right limb tremor or dyskinesia that cannot be comfortably controlled for 90 minutes.

Study Design

Enrollment

30 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • ATPmax [ Time Frame: baseline ]
  • NAD(H) metabolites [ Time Frame: baseline ]
  • Muscle force and endurance [ Time Frame: baseline ]

Central Contacts and Locations

Central contacts

Sophia Liu, PhD

206-685-3533sophia21@uw.edu

Laurie Mischley, ND, MPH, PhD

(206) 525-8012lauriemischley@mac.com

Locations

University of Washington

Recruiting

Seattle, Washington, United States, 98109

Contacts

Sophia Liu, PhD

206-685-3533sophia21@uw.edu

Eric Shankland, PhD

206-685-3533shanklan@uw.edu

More Information

Sponsor

University of Washington

Last update posted

Nov 5, 2020

Last verified

Nov, 2020

Keywords

  • Parkinson Disease
  • Mitochondria
  • Skeletal Muscle
  • Bioenergetics

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Washington on 2020-11-05.