Recruiting

MyoCI & Memory

Sponsor:

Northwestern University

Code:

NCT04312269

Conditions

Stroke

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Not accepted

Interventions

Targeted Memory Reactivation (TMR)

Study Details

Brief summary:

This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this training-plus-sleep combination will generalize to improve arm motor function over an extended training protocol in stroke survivors.

Conditions

Stroke

Study ID

NCT04312269

Start date

Feb 25, 2020

Status verified date

May, 2026

Completion date

Jan 30, 2027

Anticipated

Primary completion date

Jan 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age at enrollment is 21 or older
  • Hemiparesis from first ever stroke affecting arm movement at least 6 months prior to screening
  • Severe to moderate motor impairment (FMA-UE of 7-40)
  • At least some voluntary shoulder and elbow muscle activation

Exclusion Criteria:

  • Inability to follow instructions of the MyoCI task
  • Visual impairment (such as hemianopia) preventing full view of screen
  • Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest)
  • Participation in another study on the affected arm within 6 weeks of enrollment or any pharmacological study
  • Inability to understand or follow commands in English due to aphasia or other reason
  • Diffuse or multifocal infarcts in both hemispheres
  • Substantial arm pain preventing participation for 90 minutes a day
  • Spasticity treatment (pharmacological or Botox) within last 3 months
  • Ferromagnetic implants that are MRI incompatible

Study Design

Enrollment

70 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: All phase TMR

TMR during every stage of sleep

experimental: Slow-wave sleep (SWS) only TMR

TMR during slow-wave sleep only

experimental: Reduced frequency TMR

TMR during only subset of sessions

sham comparator: Sham TMR

Patients receive no TMR

Interventions

Targeted Memory Reactivation (TMR)

Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.

Primary outcome measure

  • Wolf Motor Function Test (WMFT) [ Time Frame: change from baseline at 6 weeks ]

Central Contacts and Locations

Central contacts

Marc W Slutzky, MD/PhD

312-503-4653mslutzky@northwestern.edu

Locations

Northwestern University

Recruiting

Chicago, Illinois, United States, 60611

More Information

Sponsor

Northwestern University

Last update posted

May 27, 2026

Last verified

May, 2026

Keywords

  • Sleep

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Northwestern University on 2026-05-27.