Recruiting

Observational Study

Sponsor:

UConn Health

Code:

NCT04321512

Conditions

Myocardial Infarction

Stroke, Ischemic

Ischemia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

There is no intervention given to the subjects

Study Details

Brief summary:

The purpose of this research study is to discover the functions of circulating white blood cells, called monocytes, and associated circulating substances in heart attack and ischemic stroke patients. Ischemic Strokes (clots) occur as a result of an obstruction within a blood vessel supplying blood to the brain. A type of monocyte carrying a surface marker called "P2X4" helps the immune system sense and respond to danger signals from the body such as heart muscle and brain tissue injuries.

The researchers expect to learn more about how these monocyte cells react to heart and brain tissue injury, and how the cells may then produce proteins or other chemical substances which promote the healing of heart muscle after heart attack and brain tissue after an ischemic stroke.

Conditions

Myocardial Infarction

Stroke, Ischemic

Ischemia

Study ID

NCT04321512

Start date

Dec 1, 2013

Status verified date

Aug, 2026

Completion date

Dec 1, 2027

Anticipated

Primary completion date

Dec 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • STEMI Patients: Men and women aged 18 years and over, with symptoms, physical signs and ECG changes characteristic of STEMI.
  • NSTEMI Patients: Men and women aged 18 years and over, with symptoms, physical signs and ECG changes characteristic of NSTEMI.
  • Stable CAD Patients: men and women aged 18 years and older with coronary artery disease proven by prior MI history, angiography or stress test but without any unstable angina or acute coronary syndrome.
  • Ischemic Stroke Patients: Men and women aged 18 years and over, with symptoms, physical signs and CT/MRI changes characteristic of ischemic stroke.
  • Healthy Controls: Men and women aged 18 years and over, without heart failure, coronary disease, hypertension, diabetes or other chronic diseases. Control subjects will be recruited from within the community of UConn Health via advertisement.

Exclusion Criteria:

  • Subjects who are unable to give informed consent (with the exception of the ischemic stroke arm patients, see Protocol Design below) and pregnant subjects.
  • Subjects who had any history of embolic, ischemic or hemorrhagic stroke within the last 12 months.

Study Design

Enrollment

300 participants

Anticipated

Interventions and Outcome Measures

Interventions

There is no intervention given to the subjects

Not appicable

Primary outcome measure

  • Hospitalization for Myocardial Infarction, Stroke, or death [ Time Frame: 3 years ]

Central Contacts and Locations

Central contacts

Kristen Siedlarz, MA

860-679-7549siedlarz@uchc.edu

Adrianna G. Perez

adrperez@uchc.edu

Locations

University of Connecticut Health Center

Recruiting

Farmington, Connecticut, United States, 06030

Contacts

Adrianna Perez

860-679-7549adrperez@uchc.edu

Principal Investigator:

Bruce Liang, MD

More Information

Sponsor

UConn Health

Last update posted

Aug 17, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by UConn Health on 2026-08-17.