Recruiting

Acute Exercise

Sponsor:

Universite du Quebec en Outaouais

Code:

NCT04348617

Conditions

Obesity

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Moderate exercise

Rest

Study Details

Brief summary:

This pilot study will use a crossover design to explore the effects of acute exercise following bariatric surgery on food intake, energy expenditure, appetite, food reward, appetite hormones, and inflammatory response. Participants will take part in a moderate-intensity exercise session and control condition of 50 minutes. The energy balance will be assessed for 3 days following the condition by giving the participants all the food they can consume for 3 days and having them wear an accelerometer.

The investigators hypothesize that post-gastric bypass participants with higher weight regain will have a higher compensation in response to exercise, thus an increase in food intake and/or a decrease in total energy expenditure after exercise compared to participants with less weight regain; also post-gastric bypass participants with a higher weight regain will have a lower inflammatory response to exercise compared to the group with less weight regain.

Conditions

Obesity

Study ID

NCT04348617

Start date

May 15, 2021

Status verified date

Oct, 2022

Completion date

Sep 30, 2023

Anticipated

Primary completion date

Mar 31, 2023

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • declare to be an adult (≥ 18 years old)
  • self-declared physically inactive (practicing less than 150 min/week of moderate to high intensity physical activity)
  • received a gastric bypass Roux-en-Y more than 24 months ago at the Ottawa Hospital
  • have regained weight ≤5%/year of total weight loss at nadir or ≥15%/year (n=15 regain)

Exclusion Criteria:

  • be pregnant, breastfeeding or menopausal
  • have depressive symptoms (score ≥16 at the Center Epidemiologic Depression-Scale)
  • take medication that may influence appetite or weight loss
  • declare they cannot walk for 50 minutes
  • be classified as high risk according to the stratification model of the ACSM (people with heart disease, Peripheral vascular or cerebrovascular disease, chronic obstructive pulmonary disease, asthma, interstitial lung disease or cystic fibrosis, type 1 and 2 diabetes, thyroid disorders, kidney or liver disease) and not having medical authorization.

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Exercise-Rest

This group will perform the exercise condition at least 1 week after the preliminary visit and will perform the resting condition a minimum of 15 days and a maximum of 2 months after the exercise condition.

experimental: Rest-Exercise

This group will perform the resting condition at least 1 week after the preliminary visit and will perform the exercise condition a minimum of 15 days and a maximum of 2 months after the resting condition.

Interventions

Moderate exercise

50 minutes of moderate exercise on treadmill

Rest

50 minutes of rest or sedentary activity

Primary outcome measure

  • Change of energy intake between rest and exercise conditions (kcal/d) [ Time Frame: At least one week after baseline evaluation (visit 2) and 15 days to a maximum of 2 months after visit 2 ]
  • Change of total energy expenditure post-experimentation between rest and exercise conditions (kcal/d) [ Time Frame: At least one week after baseline evaluation (visit 2) and 15 days to a maximum of 2 months after visit 2 ]

Central Contacts and Locations

Central contacts

aurelie Baillot

8199437561aurelie.baillot@uqo.ca

Locations

Aurelie Baillot

Recruiting

Gatineau, Quebec, Canada, j9a2y7

Contacts

aurelie baillot

8195953900aurelie.baillot@uqo.ca

More Information

Sponsor

Universite du Quebec en Outaouais

Last update posted

Nov 2, 2022

Last verified

Oct, 2022

Keywords

  • Bariatric Surgery
  • Appetite
  • Food intake
  • Energy expenditure
  • Food reward
  • Appetite hormones
  • Inflammatory response
  • acute exercise

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Universite du Quebec en Outaouais on 2022-11-02.