Recruiting

Observational Study

Sponsor:

Laval University

Code:

NCT04390360

Conditions

ARDS, Human

Mechanical Ventilation Complication

Humidifier Lung

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Protective ventilation implementation

Protective ventilation with HME

Protective ventilation with Heated humidifier

Tidal Volume reduction

Study Details

Brief summary:

Clinical evaluation of a new educative tools (Smartphone application) based on impact of instrumental dead space reduction after initiation of protective ventilation during mechanical ventilation.

Conditions

ARDS, Human

Mechanical Ventilation Complication

Humidifier Lung

Study ID

NCT04390360

Start date

Nov 1, 2019

Status verified date

Mar, 2023

Completion date

Jun 30, 2024

Anticipated

Primary completion date

Dec 30, 2023

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age > 18 years old
  • Mechanical ventilation (control,assist control or SIMV mode)
  • haemodynamic stability (vasopressor < 0.2 ug/kg/min)
  • no prone position schedule in the next 2 hours following procedure inclusion
  • presence of an Arterial catheter

Exclusion Criteria:

  • ECMO or anticipate ECMO
  • body temperature < 36.0 for post operative patient (cardiac surgery)

Study Design

Enrollment

20 participants

Anticipated

Allocation

Non randomized

Intervention Model

Crossover

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

other: Protective ventilation with HME

Protective ventilation + HME

other: Protective ventilation with Heated humidifier

Protective ventilation + HH

other: Implementation of protective ventilation

Protective ventilation implementation

other: Tidal Volume reduction

Tidal volume reduction

Interventions

Protective ventilation implementation

In this condition, we will implement the protective ventilation related with gender and height . A blood gas will be performed at before protective ventilation implementation and at the end of this condition.Time condition 30 minutes

Protective ventilation with HME

In this condition, the patient will received protective ventilation with a Heat Moisture Exchanger (HME). A blood gas will be performed at the end of this condition.Time condition 30 minutes

Protective ventilation with Heated humidifier

In this condition, the patient will received protective ventilation with a Heated humidifier. A blood gas will be performed at the end of this condition.Time condition 30 minutes

Tidal Volume reduction

n this condition, we will reduce Tidal volume (with smartphone application calculation) to obtain the same alveolar ventilation (PaCO2) obtained on the HME condition

Primary outcome measure

  • PaCO2 Variation [ Time Frame: 60 minutes post intervention ]
  • PaCO2 Variation [ Time Frame: 120 minutes post intervention ]

Central Contacts and Locations

Central contacts

François Lellouche

1-418-656-8711Francois.Lellouche@criucpq.ulaval.ca

Locations

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval

Recruiting

Quebec, Canada, G1V4G5

Contacts

Pierre-Alexandre Bouchard

418-656-8711pierre-alexandre.bouchard@criucpq.ulaval.ca

Principal Investigator:

Francois Lellouche

More Information

Sponsor

Laval University

Last update posted

Mar 10, 2023

Last verified

Mar, 2023

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Laval University on 2023-03-10.