Recruiting

Cognitive Training

Sponsor:

University of Georgia

Code:

NCT04414215

Conditions

Schizophrenia

Schizo Affective Disorder

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Interventions

Emotional working memory training

Placebo working memory training

Study Details

Brief summary:

The current study examines the efficacy of a cognitive training intervention for improving emotion regulation in psychotic disorders. it is hypothesized that the cognitive training program will enhance prefrontal activation, leading to enhanced emotion regulation.

Conditions

Schizophrenia

Schizo Affective Disorder

Study ID

NCT04414215

Start date

Jun 1, 2020

Status verified date

Feb, 2025

Completion date

Dec 31, 2029

Anticipated

Primary completion date

Dec 31, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • diagnostic and statistical manual fifth edition diagnosis of schizophrenia or schizoaffective disorder
  • 18-60 years old
  • speaks English
  • premorbid intelligence quotient > 70
  • clinically stable as indicated by no antipsychotic medication changes in the last month or if on depot, no change in the past 2 months.

Exclusion Criteria:

  • history of intellectual disability or neurological disorder
  • history of traumatic brain injury with loss of consciousness > 10 minutes or behavioral sequelae
  • substance use disorder within the last 6 months (other than nicotine)
  • 4) endorsement of MRI exclusion factors

Study Design

Enrollment

70 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Cognitive training

Emotional working memory training

placebo comparator: Placebo training

Placebo working memory training

Interventions

Emotional working memory training

Participants will complete an emotional working memory n-back training program that progressively increases difficulty and has been shown to enhance prefrontal activity in a non-psychiatric sample

Placebo working memory training

Working memory training that does not involve emotional stimuli using an N-back training program

Primary outcome measure

  • Prefrontal blood oxygen level dependent activation in the prefrontal cortex [ Time Frame: Change from baseline to 15 days or 30 days ]

Central Contacts and Locations

Central contacts

Gregory P Strauss, PhD

706-542-0307gstrauss@uga.edu

Locations

University of Georgia

Recruiting

Athens, Georgia, United States, 30602

Contacts

Gregory P Strauss, PhD

706-542-0307gstrauss@uga.edu

Principal Investigator:

Gregory P Strauss, PhD

More Information

Sponsor

University of Georgia

Last update posted

Feb 5, 2025

Last verified

Feb, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Georgia on 2025-02-05.