Recruiting

Immune Cells

Sponsor:

University of Utah

Code:

NCT04416191

Conditions

Muscle Disuse

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Limb immobilization

Study Details

Brief summary:

This is an interventional study enrolling healthy individuals aged 18-35 and 60-85 to understand the recovery of muscle health following a period of inactivity. The enrollment goal is 45 participants. The study will occur over the course of 1-2 months where participants will undergo testing before and after a 2-week limb immobilization period.

Conditions

Muscle Disuse

Study ID

NCT04416191

Start date

May 15, 2022

Status verified date

Dec, 2025

Completion date

Apr 30, 2028

Anticipated

Primary completion date

Apr 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Age between 18-35 and 60-85 yrs
2. Ability to sign informed consent
3. Free-living, prior to admission

Exclusion Criteria:

  • History of cardiovascular disease (e.g., CHF, CAD, right-to-left shunt)
  • History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes
  • History of kidney disease or failure
  • Vascular disease
  • Risk of DVT including family history of thrombophilia, DVT, pulmonary emboli, myeloproliferative diseases including polycythemia (Hb>18 g/dL) or thrombocytosis (platelets>400x103/mL), and connective tissue diseases (positive lupus anticoagulant), hyperhomocystinemia, deficiencies of factor V Leiden, proteins S and C, and antithrombine III
  • Use of anticoagulant therapy (e.g., Coumadin, heparin)
  • Elevated systolic pressure >150 or a diastolic blood pressure > 100
  • Implanted electronic devices (e.g., pacemakers, electronic infusion pumps, stimulators)
  • Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
  • Currently on a weight-loss diet
  • Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids are permitted)
  • Androgens or growth hormone within 6 months of enrollment and for study duration (topical physiologic androgen replacement is permitted)
  • History of stroke with motor disability
  • A recent history (<12 months) of GI bleed
  • History of liver disease
  • History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)
  • Pregnancy as determined by a pregnancy test
  • Any staff members who report directly to an investigator or who report to someone who reports directly to an investigator.
  • Any other condition or event considered exclusionary by the PI and faculty physician

Study Design

Enrollment

45 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: Limb immobilization

Participants will undergo a 2-week leg immobilization period

Interventions

Limb immobilization

Participants will undergo a 2-week period of leg immobilization

Primary outcome measure

  • Thigh Muscle Volume [ Time Frame: baseline and after 2 weeks of leg immobilization ]
  • Leg Muscle Strength [ Time Frame: baseline and after 2 weeks of leg immobilization ]

Central Contacts and Locations

Central contacts

Micah Drummond, PhD

801-213-2737micah.drummond@hsc.utah.edu

Locations

The University of Utah

Recruiting

Salt Lake City, Utah, United States, 84112

Contacts

Micah Drummond, PhD

8015877764

micah.drummond@hsc.utah.edu

Principal Investigator:

Micah Drummond

More Information

Sponsor

University of Utah

Last update posted

Dec 5, 2025

Last verified

Dec, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Utah on 2025-12-05.