Recruiting

ERAS

Sponsor:

Joshua Lawrenz

Code:

NCT04461171

Conditions

Sarcoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Enhanced Recovery After Surgery

Study Details

Brief summary:

The purpose of this study is to demonstrate the efficacy of implementing the enhanced recovery after surgery (ERAS) pathway in a prospective manner to patients undergoing surgical treatment for extremity sarcoma.

Conditions

Sarcoma

Study ID

NCT04461171

Start date

Dec 14, 2020

Status verified date

Nov, 2025

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Any patient at Vanderbilt University Medical Center treated with surgical excision of a suspected extremity sarcoma
  • Adult patients >17 years of age
  • Patients of all preoperative opioid status (naïve or dependent)

Exclusion Criteria:

  • Patients treated non-operatively
  • Non-English speaking patients

Study Design

Enrollment

120 participants

Anticipated

Allocation

Non randomized

Intervention Model

Sequential

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: ERAS

Administration of a perioperative non-narcotic, multimodal pain management pathway.

no intervention: Non-ERAS (Conventional)

Administration of a conventional perioperative pain management pathway that consists of both narcotic and non-narcotic pain medications.

Interventions

Enhanced Recovery After Surgery

Undergo an enhanced recovery after surgery program

Primary outcome measure

  • Pain scores [ Time Frame: 3 months ]
  • Pain scores [ Time Frame: 3 months ]
  • Limb function [ Time Frame: 3 months ]
  • Clinical outcomes - length of hospital stay [ Time Frame: 3 months ]
  • Clinical outcomes - opioid requirements [ Time Frame: 3 months ]
  • Clinical outcomes - perioperative complications (e.g. wound complications and 30-day readmission) [ Time Frame: 3 months ]

Central Contacts and Locations

Central contacts

Vanderbilt-Ingram Service for Timely Access

800-811-8480cip@vumc.org

Locations

Vanderbilt University Medical Center

Recruiting

Nashville, Tennessee, United States, 37232

Contacts

Vanderbilt-Ingram Service for Timely Access

800-811-8480cip@vumc.org

Principal Investigator:

Joshua M Lawrenz, MD

More Information

Sponsor

Joshua Lawrenz

Last update posted

Aug 21, 2026

Last verified

Nov, 2025

Keywords

  • Enhanced Recovery After Surgery

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Joshua Lawrenz on 2026-08-21.