PrEP InterventionPrEP Intervention for People Who Inject Substances and Use Methamphetamine

Inclusion Criteria:

Participants are eligible to be included in the study only if all of the following criteria apply:

1. Age 18-65 years inclusive,
2. Assigned male sex at birth,
3. Past 30-day methamphetamine use on 4 or more days, by self-report,
4. ≥ 1 positive methamphetamine urine toxicology,
5. Either interested in initiating PrEP OR currently on daily PrEP with sub-optimal adherence (measured as missing at least one dose of one's PrEP in the past 30 days, by self-report),
6. Reports condomless sero-unknown/discordant anal or insertive vaginal sex with a person of any gender in the past 12 months,
7. HIV-negative,
8. Reliable access to a computer to complete study visits, if participating remotely, AND
9. Proficient in English

Exclusion Criteria:

Participants are excluded from the study if any of the following criteria apply:

1. On PrEP for more than 6 months,
2. Unwillingness to use a video app to record oneself taking PrEP, OR
3. Any other circumstances that, in the opinion of the investigators, would compromise participant safety and/or successful completion of the trial.

For participants receiving PrEP from the study team, exclusion criteria will include the following:
4. Contraindication to tenofovir or emtricitabine-containing products,
5. Creatinine clearance ≤30 mL/min, OR
6. Positive hepatitis B surface antigen test.