Recruiting

Observational Study

Sponsor:

University of Denver

Code:

NCT04532242

Conditions

Behavior

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Interventions

Cognitive reappraisal

Study Details

Brief summary:

Community participants will visit the neuroimaging facilities at CU Boulder for a single experimental session. In all studies, participants will complete pre-task questionnaires (trait measures), and a brief mood measure, followed by a task training in which a research assistant describes and gives examples of cognitive reappraisal in response to negative images. Then, participants complete an event-related, picture-based cognitive reappraisal task for 30-45 minutes, during which whole-brain BOLD signal will be collected. Following the task, participants will once again respond to a mood measure, and answer a series of questions regarding the task they have completed, including difficulty of regulation, or any images that were personally relevant.

The researchers predict that the positive emotion induction will result in powerful effects on self-reported emotion which may or may not interact with the cognitive reappraisal condition. Participants will be trained to use reappraisal to increase positive emotion, and they will be asked to respond with the reappraisal tactic category that best fits the reappraisal they used for each image. The researchers predict greater use of future-focused tactics will be associated with greater reappraisal success, which in turn will result in greater recruitment of vmPFC and connectivity between vmPFC and other prefrontal regions.

Conditions

Behavior

Study ID

NCT04532242

Start date

Jun 22, 2023

Status verified date

Jul, 2023

Completion date

Nov 1, 2023

Anticipated

Primary completion date

Aug 31, 2023

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Community members ages 18-55
  • Fluent in English
  • Without present psychotic symptoms

Exclusion Criteria:

  • None

Study Design

Enrollment

40 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: fMRI Participants

Participants will be scanned in an fMRI session lasting approximately 45-50 minutes and will be shown negative images for which they will have to take on a cognitive reappraisal tactic. All participants will be taken through the scanner with the same reappraisal protocol for each participant.

Interventions

Cognitive reappraisal

Participants will be trained to follow instructions to look/respond naturally or use cognitive reappraisal to reframe or reconsider a negative picture to decrease negative emotion.

Primary outcome measure

  • Self-reported emotion ratings [ Time Frame: During the task intervention which will last 50 minutes ]
  • Whole brain BOLD signal [ Time Frame: Immediately after the intervention ]

Central Contacts and Locations

Central contacts

Alyssa Asmar, B.A

alyssa.asmar@du.edu

Locations

University of Denver

Recruiting

Denver, Colorado, United States, 80208

Contacts

More Information

Sponsor

University of Denver

Last update posted

Jul 25, 2023

Last verified

Jul, 2023

Keywords

  • cognitive reappraisal
  • cognition

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Denver on 2023-07-25.