Recruiting
Phase 3

Daratumumab, Bortezomib, Lenalidomide, Dexamethasone

Sponsor:

ECOG-ACRIN Cancer Research Group

Code:

NCT04566328

Conditions

Plasma Cell Myeloma

RISS Stage I Plasma Cell Myeloma

RISS Stage II Plasma Cell Myeloma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Bortezomib

Daratumumab and Hyaluronidase-fihj

Dexamethasone

Lenalidomide

Quality-of-Life Assessment

Study Details

Brief summary:

This phase III trial compares the combination of four drugs (daratumumab, bortezomib, lenalidomide and dexamethasone) to the use of a three drug combination (daratumumab, lenalidomide and dexamethasone). Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as lenalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Daratumumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Anti-inflammatory drugs, such as dexamethasone lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Adding bortezomib to daratumumab, lenalidomide, and dexamethasone may be more effective in shrinking the cancer or preventing it from returning, compared to continuing on daratumumab, lenalidomide, and dexamethasone.

Conditions

Plasma Cell Myeloma

RISS Stage I Plasma Cell Myeloma

RISS Stage II Plasma Cell Myeloma

Study ID

NCT04566328

Start date

Feb 24, 2021

Status verified date

Jun, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • STEP 0 - Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-2 (PS 3 allowed if secondary to pain)
  • STEP 0 - Patient must have newly diagnosed multiple myeloma (MM) by International Myeloma Working Group (IMWG) criteria
  • STEP 0 - Patient must agree to register to the mandatory REVLIMID Risk Evaluation and Mitigation Strategy (RevREMS) program and be willing and able to comply with the requirements of RevREMS
  • STEP 0 - Patient must be able to undergo diagnostic bone marrow aspirate following preregistration.

  • NOTE: Bone marrow aspirate specimen must be submitted to Adaptive Biotechnologies for clonoSEQ Assay
  • NOTE: Adaptive Biotechnologies will release results to the diagnostic Portal from the Clonality (ID) test within fourteen (14) days of receipt and reconciliation of fresh bone marrow specimen to the submitting institution
  • STEP 1 - Patient must meet all eligibility criteria in STEP 0 with exception of allergy requirement
  • STEP 1 - Institution must have received the Clonality (ID) test results from Adaptive Biotechnologies and dominant sequences were identified
  • STEP 1 - Patient must have standard risk MM as defined by the Revised International Staging System (RISS) stage I or II

  • NOTE: R-ISS stage is based on serum beta2 microglobulin, albumin and lactate dehydrogenase (LDH) levels along with presence of chromosomal abnormalities (CA) detected by interphase fluorescent in situ hybridization (iFISH). Presence of del(17p), t(4;14), and/or t(14;16) is considered high risk and absence of these, including any other findings, are standard risk
  • R-ISS stage

  • Stage I: ISS stage I \[beta2 macroglobulin < 3.5 mg/L, albumin > 3.5 g/dL\] AND standard-risk CA AND normal LDH
  • Stage II: Not R-ISS stage I or III
  • Stage III: ISS stage III \[beta2 macroglobulin > 5.5 mg/L\] AND high-risk CA OR high LDH (> upper limit of normal) \[patients with stage III are ineligible\]
  • STEP 1 - Patient must have measurable or evaluable disease as defined by having one or more of the following, obtained within 28 days prior to registration:

  • >= 1 g/dL monoclonal protein (M-protein) on serum protein electrophoresis
  • >= 200 mg/24 hours of monoclonal protein on a 24-hour urine protein electrophoresis
  • Involved free light chain >= 10 mg/dL or >= 100 mg/L AND abnormal serum immunoglobulin kappa to lambda free light chain ratio (< 0.26 or > 1.65)
  • Monoclonal bone marrow plasmacytosis >= 30% (evaluable disease)
  • STEP 1 - Patients must have a serum protein electrophoresis (SPEP), urine protein electrophoresis (UPEP), and serum free light chain (FLC) assay performed within 28 days prior to registration. In addition, a bone marrow biopsy and/or aspirate is required within 28 days if bone marrow is being followed for response

  • NOTE: UPEP (on a 24-hour collection) is required, no substitute method is acceptable. Urine must be followed monthly if the baseline urine M-spike is >= 200 mg/24 hr. Please note that if both serum and urine M-components are present, both must be followed in order to evaluate response
  • NOTE: The serum free light chain test is required to be done if the patient does not have measurable disease in the serum or urine. Measurable disease in the serum is defined as having a serum M-spike >= 1 g/dL. Measurable disease in the urine is defined as having a urine M-spike >= 200 mg/24 hr
  • STEP 1 - Calculated creatinine clearance > 30 mL/min (obtained =< 14 days prior to Step 1 registration)
  • STEP 1 - Absolute neutrophil count (ANC) >= 1000/mm\^3 (obtained =< 14 days prior to Step 1 registration)
  • STEP 1 - Untransfused platelet count >= 75,000/mm\^3 (obtained =< 14 days prior to Step 1 registration)
  • STEP 1 - Hemoglobin >= 8.0 g/dL (obtained =< 14 days prior to Step 1 registration)
  • STEP 1 - Total bilirubin =< 1.5 x ULN (institutional upper limit of normal) (obtained =< 14 days prior to Step 1 registration)
  • STEP 1 - Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN (obtained =< 14 days prior to Step 1 registration)
  • STEP 1 - Patient must have received no more than one cycle (28 days or less) of prior chemotherapy and no more than 160 mg of prior dexamethasone (or equivalent dose of prednisone) for treatment of symptomatic myeloma. Patient must not have been exposed to daratumumab for treatment of symptomatic myeloma. Prior radiation therapy to symptomatic lesions is allowed provided there are no residual toxicity related to radiation and blood counts meet the study requirements. Radiation treatment must be completed at least 14 days prior to Step 1 registration
  • STEP 1 - Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial
  • STEP 1 - For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
  • STEP 1 - Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
  • STEP 1 - Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
  • STEP 1 - Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better. Patients must not have evidence of current uncontrolled cardiovascular conditions, including hypertension, cardiac arrhythmias, congestive heart failure, unstable angina, or myocardial infarction within 6 months prior to Step 1 registration
  • STEP 1 - Patient may have a history of current or previous deep vein thrombosis (DVT) or pulmonary embolism (PE) but must be willing to take some form of anti-coagulation as prophylaxis if they are not currently on full-dose anticoagulation
  • STEP 1 - Patients with a history of chronic obstructive pulmonary disease (COPD) must have FEV1 testing done within 28 days prior to Step 1 registration and the forced expiratory volume in 1 second (FEV1) must be > 50% of predicted normal
  • STEP 2 - Institution must have received Tracking (MRD) test results from Adaptive Biotechnologies
  • STEP 2 - Patient must have completed the Step 1 Induction phase of this protocol without experiencing progression
  • STEP 2 - Patient must be registered to Step 2 within 8 weeks of completing Step 1 Induction Treatment, counting from last day of completion of last cycle
  • STEP 2 - Patient must have an ECOG performance status (PS) of 0-2 (PS 3 allowed if secondary to pain)
  • STEP 2 - Any adverse event(s) related to Step 1 Induction Treatment must have resolved to grade 2 or less
  • STEP 2 - Hemoglobin >= 8 g/dL (obtained within 14 days prior to Step 2 randomization)
  • STEP 2 - Platelet count >= 50,000/mm\^3 (obtained within 14 days prior to Step 2 randomization)
  • STEP 2 - Absolute neutrophil count (ANC) >= 1000/mm\^3 (obtained within 14 days prior to Step 2 randomization)
  • STEP 2 - Calculated creatinine clearance >= 30 mL/min (obtained within 14 days prior to Step 2 randomization)
  • STEP 2 - Total bilirubin =< 1.5 x ULN (Institutional upper limit of normal) (obtained within 14 days prior to Step 2 randomization)
  • STEP 2 - ALT and AST < 3 x ULN (obtained within 14 days prior to Step 2 randomization)

Exclusion Criteria:

  • STEP 0 - Patient must not have any known allergies, hypersensitivity, or intolerance to corticosteroids, monoclonal antibodies or human proteins, or their excipients (refer to respective package inserts or Investigator's Brochure), or known sensitivity to mammalian-derived products
  • STEP 1 - Women must not be pregnant or breast-feeding due to the potential harm and teratogenic effects to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All females of childbearing potential must have a blood test or urine study with a sensitivity of at least 25 mIU/mL within 10-14 days prior to Step 1 registration to rule out pregnancy and again within 24 hours prior to the first dose of lenalidomide. Females of childbearing potential must also agree to ongoing pregnancy testing while on protocol treatment. A female of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria:

  • Has achieved menarche at some point,
  • Has not undergone a hysterectomy or bilateral oophorectomy; or
  • Has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • STEP 1 - Women of childbearing potential must not expect to conceive children by using accepted and effective method(s) of contraception (for this protocol defined as the use of TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME for 1) at least 28 days before starting protocol treatment; 2) while participating in the study; 3) during dose interruptions; and 4) for at least 3 months days after the last dose of protocol treatment) OR by practicing true abstinence from sexual intercourse for the duration of their participation in the study (periodic abstinence \[e.g., calendar, ovulation, symptothermal, post-ovulation methods\] and withdrawal are not acceptable methods of contraception). Men must not expect to father children by practicing true abstinence from sexual intercourse for the duration of their participation in the study (periodic abstinence \[e.g., calendar, ovulation, symptothermal, post-ovulation methods\] and withdrawal are not acceptable methods of contraception) OR use a latex condom during sexual contact with a female of child bearing potential while participating in the study and for at least 3 months after the last dose of protocol treatment even if they have had a successful vasectomy. Men must also agree to abstain from donating sperm while on study treatment and for 3 months after the last dose of protocol treatment even if they have had a successful vasectomy. Both women and men must both agree to abstain from donating blood during study participation and for at least 28 days after the last dose of protocol treatment
  • STEP 1 - Patient must not have peripheral neuropathy >= grade 2 on clinical examination or grade 1 with pain at time of Step 1 registration
  • STEP 1 - Patient must not have any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol
  • STEP 1 - Patient must not have moderate or severe persistent asthma within the past 2 years, or uncontrolled asthma of any classification

  • NOTE: Patients who currently have controlled intermittent asthma or controlled mild persistent asthma are allowed to register
  • STEP 1 - Patient must not receive any other concurrent chemotherapy, or any ancillary therapy considered investigational while on this protocol

  • NOTE: Bisphosphonates are considered to be supportive care rather than therapy, and are thus allowed while on protocol treatment
  • STEP 2 - Patient must not have received any non-protocol therapy outside of the assigned Step 1 Induction treatment including stem cell transplant
  • STEP 2 - Women must not be pregnant or breast-feeding due to the potential harm and teratogenic effects to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All females of childbearing potential must have a blood test or urine study with a sensitivity of at least 25 mIU/mL within 10-14 days prior to Step 2 randomization to rule out pregnancy and again within 24 hours prior to the first dose of lenalidomide. Females of childbearing potential must also agree to ongoing pregnancy testing while on protocol treatment. A female of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria:

  • Has achieved menarche at some point,
  • Has not undergone a hysterectomy or bilateral oophorectomy; or
  • Has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months).
  • STEP 2 - Women of childbearing potential must not expect to conceive children by using accepted and effective method(s) of contraception (for this protocol defined as the use of TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME for 1) at least 28 days before starting protocol treatment; 2) while participating in the study; 3) during dose interruptions; and 4) for at least 3 months days after the last dose of protocol treatment) OR by practicing true abstinence from sexual intercourse for the duration of their participation in the study (periodic abstinence \[e.g., calendar, ovulation, symptothermal, post-ovulation methods\] and withdrawal are not acceptable methods of contraception).

Men must not expect to father children by practicing true abstinence from sexual intercourse for the duration of their participation in the study (periodic abstinence \[e.g., calendar, ovulation, symptothermal, post-ovulation methods\] and withdrawal are not acceptable methods of contraception) OR use a latex condom during sexual contact with a female of child bearing potential while participating in the study and for at least 3 months after the last dose of protocol treatment even if they have had a successful vasectomy. Men must also agree to abstain from donating sperm while on study treatment and for 3 months after the last dose of protocol treatment even if they have had a successful vasectomy. Both women and men must both agree to abstain from donating blood during study participation and for at least 28 days after the last dose of protocol treatment

Study Design

Enrollment

1450 participants

Anticipated

Allocation

Randomized

Intervention Model

Sequential

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Arm A (daratumumab, lenalidomide, dexamethasone)

INDUCTION: All patients receive standard induction therapy comprising the following: daratumumab subcutaneously (SC) on days 1, 8, 15, and 22 of cycles 1-2, days 1 and 15 of cycles 3-6, and day 1 of cycles 7-9, lenalidomide orally (PO) daily on days 1-21, and dexamethasone PO on days 1, 8, 15, and 22. Treatment repeats every 28 days for 9 cycles in the absence of disease progression or unacceptable toxicity.

experimental: Arm B (bortezomib, daratumumab, lenalidomide, dexamethasone)

CONSOLIDATION: Patients receive bortezomib SC on days 1, 8, and 15, daratumumab SC on day 1, lenalidomide PO daily on days 1-21, and dexamethasone PO on days 1, 8, 15, and 22. Treatment repeats every 28 days for 9 cycles in the absence of disease progression or unacceptable toxicity.

MAINTENANCE: Patients receive lenalidomide PO daily on days 1-21 and daratumumab SC on day 1. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

active comparator: Arm C (daratumumab, lenalidomide, dexamethasone)

CONSOLIDATION: Patients receive daratumumab SC on day 1, lenalidomide PO daily on days 1-21, and dexamethasone PO on days 1, 8, 15, and 22. Treatment repeats every 28 days for 9 cycles in the absence of disease progression or unacceptable toxicity.

MAINTENANCE: Patients receive lenalidomide PO daily on days 1-21, and daratumumab SC on day 1. Cycles repeats every 28 days in the absence of disease progression or unacceptable toxicity.

Interventions

Bortezomib

Given SC

Daratumumab and Hyaluronidase-fihj

Given SC

Dexamethasone

Given PO

Lenalidomide

Given PO

Quality-of-Life Assessment

Ancillary studies

Primary outcome measure

  • Consolidation overall survival [ Time Frame: Time from Step 2 randomization at the start of consolidation to death or to the date last known alive, assessed up to 15 years ]

Central Contacts and Locations

Locations

Cancer Center at Saint Joseph's

Recruiting

Phoenix, Arizona, United States, 85004

Contacts

Principal Investigator:

Shahzad Siddique

Mercy Hospital Fort Smith

Recruiting

Fort Smith, Arkansas, United States, 72903

Contacts

Site Public Contact

800-378-9373

Principal Investigator:

Jay W. Carlson

CARTI Cancer Center

Recruiting

Little Rock, Arkansas, United States, 72205

Contacts

Principal Investigator:

Jay W. Carlson

Mission Hope Medical Oncology - Arroyo Grande

Recruiting

Arroyo Grande, California, United States, 93420

Contacts

Principal Investigator:

Shahzad Siddique

Mercy Cancer Center - Carmichael

Recruiting

Carmichael, California, United States, 95608

Contacts

Principal Investigator:

Shahzad Siddique

Mercy San Juan Medical Center

Recruiting

Carmichael, California, United States, 95608

Contacts

Principal Investigator:

Shahzad Siddique

Mercy Cancer Center - Elk Grove

Recruiting

Elk Grove, California, United States, 95758

Contacts

Principal Investigator:

Shahzad Siddique

Washington Health

Recruiting

Fremont, California, United States, 94538

Contacts

Site Public Contact

510-248-1600

Principal Investigator:

Matthew E. Tenold

Mercy Cancer Center

Recruiting

Merced, California, United States, 95340

Contacts

Principal Investigator:

Shahzad Siddique

Mercy Cancer Center - Rocklin

Recruiting

Rocklin, California, United States, 95765

Contacts

Principal Investigator:

Shahzad Siddique

Mercy Cancer Center - Sacramento

Recruiting

Sacramento, California, United States, 95816

Contacts

Principal Investigator:

Shahzad Siddique

Pacific Central Coast Health Center-San Luis Obispo

Recruiting

San Luis Obispo, California, United States, 93401

Contacts

Principal Investigator:

Shahzad Siddique

Mission Hope Medical Oncology - Santa Maria

Recruiting

Santa Maria, California, United States, 93444

Contacts

Principal Investigator:

Shahzad Siddique

Saint Joseph's Medical Center

Recruiting

Stockton, California, United States, 95204

Contacts

Site Public Contact

209-461-5257

Principal Investigator:

Shahzad Siddique

Woodland Memorial Hospital

Recruiting

Woodland, California, United States, 95695

Contacts

Principal Investigator:

Shahzad Siddique

Penrose-Saint Francis Healthcare

Recruiting

Colorado Springs, Colorado, United States, 80907

Contacts

Principal Investigator:

Shahzad Siddique

Rocky Mountain Cancer Centers-Penrose

Recruiting

Colorado Springs, Colorado, United States, 80907

Contacts

Principal Investigator:

Shahzad Siddique

Saint Francis Cancer Center

Recruiting

Colorado Springs, Colorado, United States, 80923

Contacts

Principal Investigator:

Shahzad Siddique

CommonSpirit Saint Anthony Hospital Cancer Center

Recruiting

Lakewood, Colorado, United States, 80228

Contacts

Principal Investigator:

Shahzad Siddique

Saint Mary Corwin Medical Center

Recruiting

Pueblo, Colorado, United States, 81004

Contacts

Principal Investigator:

Shahzad Siddique

Saint Anthony North Hospital

Recruiting

Westminster, Colorado, United States, 80023

Contacts

Principal Investigator:

Shahzad Siddique

Smilow Cancer Hospital-Derby Care Center

Recruiting

Derby, Connecticut, United States, 06418

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Hospital Care Center-Fairfield

Recruiting

Fairfield, Connecticut, United States, 06824

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Hospital Care Center at Glastonbury

Recruiting

Glastonbury, Connecticut, United States, 06033

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Hospital Care Center at Greenwich

Recruiting

Greenwich, Connecticut, United States, 06830

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Hospital Care Center - Guilford

Recruiting

Guilford, Connecticut, United States, 06437

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Hospital Care Center at Saint Francis

Recruiting

Hartford, Connecticut, United States, 06105

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Center/Yale-New Haven Hospital

Recruiting

New Haven, Connecticut, United States, 06510

Contacts

Principal Investigator:

Sabrina Browning

Yale University

Recruiting

New Haven, Connecticut, United States, 06520

Contacts

Principal Investigator:

Sabrina Browning

Yale-New Haven Hospital North Haven Medical Center

Recruiting

North Haven, Connecticut, United States, 06473

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Hospital-Orange Care Center

Recruiting

Orange, Connecticut, United States, 06477

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Hospital-Torrington Care Center

Recruiting

Torrington, Connecticut, United States, 06790

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Hospital Care Center-Trumbull

Recruiting

Trumbull, Connecticut, United States, 06611

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Hospital-Waterbury Care Center

Recruiting

Waterbury, Connecticut, United States, 06708

Contacts

Principal Investigator:

Sabrina Browning

Smilow Cancer Hospital Care Center - Waterford

Recruiting

Waterford, Connecticut, United States, 06385

Contacts

Principal Investigator:

Sabrina Browning

Sibley Memorial Hospital

Recruiting

Washington D.C., District of Columbia, United States, 20016

Contacts

Principal Investigator:

Sarah Waheed

Holy Cross Hospital

Recruiting

Fort Lauderdale, Florida, United States, 33308

Contacts

Site Public Contact

eileen.georgi@holy-cross.com

Principal Investigator:

Elie G. Dib

Saint Alphonsus Cancer Care Center-Boise

Recruiting

Boise, Idaho, United States, 83706

Contacts

Principal Investigator:

Elie G. Dib

Saint Alphonsus Cancer Care Center-Caldwell

Recruiting

Caldwell, Idaho, United States, 83605

Contacts

Principal Investigator:

Elie G. Dib

Saint Alphonsus Cancer Care Center-Nampa

Recruiting

Nampa, Idaho, United States, 83687

Contacts

Principal Investigator:

Elie G. Dib

OSF Saint Anthony's Health Center

Recruiting

Alton, Illinois, United States, 62002

Contacts

Site Public Contact

618-463-5623

Principal Investigator:

Jay W. Carlson

Advocate Outpatient Center - Aurora

Recruiting

Aurora, Illinois, United States, 60506

Contacts

Site Public Contact

ncorp@aah.org

Principal Investigator:

Thomas J. Saphner

Advocate Good Shepherd Hospital

Recruiting

Barrington, Illinois, United States, 60010

Contacts

Site Public Contact

847-842-4847

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Bloomington

Recruiting

Bloomington, Illinois, United States, 61704

Contacts

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Canton

Recruiting

Canton, Illinois, United States, 61520

Contacts

Principal Investigator:

Bryan A. Faller

Memorial Hospital of Carbondale

Recruiting

Carbondale, Illinois, United States, 62902

Contacts

Principal Investigator:

Bryan A. Faller

SIH Cancer Institute

Recruiting

Carterville, Illinois, United States, 62918

Contacts

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Carthage

Recruiting

Carthage, Illinois, United States, 62321

Contacts

Principal Investigator:

Bryan A. Faller

Centralia Oncology Clinic

Recruiting

Centralia, Illinois, United States, 62801

Contacts

Principal Investigator:

Bryan A. Faller

Advocate Illinois Masonic Medical Center

Recruiting

Chicago, Illinois, United States, 60657

Contacts

Site Public Contact

773-296-5360

Principal Investigator:

Thomas J. Saphner

AMG Crystal Lake - Oncology

Recruiting

Crystal Lake, Illinois, United States, 60014

Contacts

Principal Investigator:

Thomas J. Saphner

Cancer Care Specialists of Illinois - Decatur

Recruiting

Decatur, Illinois, United States, 62526

Contacts

Principal Investigator:

Bryan A. Faller

Decatur Memorial Hospital

Recruiting

Decatur, Illinois, United States, 62526

Contacts

Principal Investigator:

Bryan A. Faller

Northwestern Medicine Cancer Center Kishwaukee

Recruiting

DeKalb, Illinois, United States, 60115

Contacts

Principal Investigator:

Renee Cheng

Illinois CancerCare-Dixon

Recruiting

Dixon, Illinois, United States, 61021

Contacts

Site Public Contact

815-285-7800

Principal Investigator:

Bryan A. Faller

Advocate Good Samaritan Hospital

Recruiting

Downers Grove, Illinois, United States, 60515

Contacts

Principal Investigator:

Thomas J. Saphner

Crossroads Cancer Center

Recruiting

Effingham, Illinois, United States, 62401

Contacts

Principal Investigator:

Bryan A. Faller

Advocate Sherman Hospital

Recruiting

Elgin, Illinois, United States, 60123

Contacts

Site Public Contact

847-429-2907

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Eureka

Recruiting

Eureka, Illinois, United States, 61530

Contacts

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Galesburg

Recruiting

Galesburg, Illinois, United States, 61401

Contacts

Principal Investigator:

Bryan A. Faller

Northwestern Medicine Cancer Center Delnor

Recruiting

Geneva, Illinois, United States, 60134

Contacts

Principal Investigator:

Renee Cheng

Advocate South Suburban Hospital

Recruiting

Hazel Crest, Illinois, United States, 60429

Contacts

Site Public Contact

708-799-9995

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Kewanee Clinic

Recruiting

Kewanee, Illinois, United States, 61443

Contacts

Principal Investigator:

Bryan A. Faller

AMG Libertyville - Oncology

Recruiting

Libertyville, Illinois, United States, 60048

Contacts

Principal Investigator:

Thomas J. Saphner

Condell Memorial Hospital

Recruiting

Libertyville, Illinois, United States, 60048

Contacts

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Macomb

Recruiting

Macomb, Illinois, United States, 61455

Contacts

Principal Investigator:

Bryan A. Faller

SSM Health Good Samaritan

Recruiting

Mount Vernon, Illinois, United States, 62864

Contacts

Principal Investigator:

Jay W. Carlson

Cancer Care Center of O'Fallon

Recruiting

O'Fallon, Illinois, United States, 62269

Contacts

Principal Investigator:

Bryan A. Faller

HSHS Saint Elizabeth's Hospital

Recruiting

O'Fallon, Illinois, United States, 62269

Contacts

Principal Investigator:

Bryan A. Faller

Advocate Christ Medical Center

Recruiting

Oak Lawn, Illinois, United States, 60453-2699

Contacts

Site Public Contact

800-323-8622

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Ottawa Clinic

Recruiting

Ottawa, Illinois, United States, 61350

Contacts

Principal Investigator:

Bryan A. Faller

Advocate Lutheran General Hospital

Recruiting

Park Ridge, Illinois, United States, 60068

Contacts

Site Public Contact

847-384-3621

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Pekin

Recruiting

Pekin, Illinois, United States, 61554

Contacts

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Peoria

Recruiting

Peoria, Illinois, United States, 61615

Contacts

Principal Investigator:

Bryan A. Faller

Methodist Medical Center of Illinois

Recruiting

Peoria, Illinois, United States, 61636

Contacts

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Peru

Recruiting

Peru, Illinois, United States, 61354

Contacts

Principal Investigator:

Bryan A. Faller

Valley Radiation Oncology

Recruiting

Peru, Illinois, United States, 61354

Contacts

Site Public Contact

815-664-4141

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Princeton

Recruiting

Princeton, Illinois, United States, 61356

Contacts

Principal Investigator:

Bryan A. Faller

Southern Illinois University School of Medicine

Recruiting

Springfield, Illinois, United States, 62702

Contacts

Site Public Contact

217-545-7929

Principal Investigator:

Bryan A. Faller

Springfield Clinic

Recruiting

Springfield, Illinois, United States, 62702

Contacts

Site Public Contact

800-444-7541

Principal Investigator:

Bryan A. Faller

Springfield Memorial Hospital

Recruiting

Springfield, Illinois, United States, 62781

Contacts

Principal Investigator:

Bryan A. Faller

Northwestern Medicine Cancer Center Warrenville

Recruiting

Warrenville, Illinois, United States, 60555

Contacts

Principal Investigator:

Renee Cheng

Illinois CancerCare - Washington

Recruiting

Washington, Illinois, United States, 61571

Contacts

Principal Investigator:

Bryan A. Faller

Indiana University/Melvin and Bren Simon Cancer Center

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

Principal Investigator:

Rafat Abonour

Mary Greeley Medical Center

Recruiting

Ames, Iowa, United States, 50010

Contacts

Site Public Contact

515-956-4132

Principal Investigator:

Joseph J. Merchant

McFarland Clinic - Ames

Recruiting

Ames, Iowa, United States, 50010

Contacts

Principal Investigator:

Joseph J. Merchant

UI Health Care Mission Cancer and Blood - Ankeny Clinic

Recruiting

Ankeny, Iowa, United States, 50023

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Seema Harichand-Herdt

Saint Anthony Regional Hospital

Recruiting

Carroll, Iowa, United States, 51401

Contacts

Principal Investigator:

Seema Harichand-Herdt

Mercy Hospital

Recruiting

Cedar Rapids, Iowa, United States, 52403

Contacts

Site Public Contact

319-365-4673

Principal Investigator:

Deborah W. Wilbur

Oncology Associates at Mercy Medical Center

Recruiting

Cedar Rapids, Iowa, United States, 52403

Contacts

Site Public Contact

319-363-2690

Principal Investigator:

Deborah W. Wilbur

Mercy Cancer Center-West Lakes

Recruiting

Clive, Iowa, United States, 50325

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Richard L. Deming

UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Recruiting

Clive, Iowa, United States, 50325

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Seema Harichand-Herdt

Greater Regional Medical Center

Recruiting

Creston, Iowa, United States, 50801

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Richard L. Deming

Iowa Methodist Medical Center

Recruiting

Des Moines, Iowa, United States, 50309

Contacts

Site Public Contact

515-241-6727

Principal Investigator:

Seema Harichand-Herdt

UI Health Care Mission Cancer and Blood - Des Moines Clinic

Recruiting

Des Moines, Iowa, United States, 50309

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Seema Harichand-Herdt

Broadlawns Medical Center

Recruiting

Des Moines, Iowa, United States, 50314

Contacts

Site Public Contact

515-282-2200

Principal Investigator:

Seema Harichand-Herdt

Mercy Medical Center - Des Moines

Recruiting

Des Moines, Iowa, United States, 50314

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Richard L. Deming

UI Health Care Mission Cancer and Blood - Laurel Clinic

Recruiting

Des Moines, Iowa, United States, 50314

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Seema Harichand-Herdt

Iowa Lutheran Hospital

Recruiting

Des Moines, Iowa, United States, 50316

Contacts

Site Public Contact

515-241-8704

Principal Investigator:

Seema Harichand-Herdt

McFarland Clinic - Trinity Cancer Center

Recruiting

Fort Dodge, Iowa, United States, 50501

Contacts

Site Public Contact

515-956-4132

Principal Investigator:

Joseph J. Merchant

UI Healthcare Mission Cancer and Blood - Fort Dodge

Recruiting

Fort Dodge, Iowa, United States, 50501

Contacts

Principal Investigator:

Seema Harichand-Herdt

McFarland Clinic - Marshalltown

Recruiting

Marshalltown, Iowa, United States, 50158

Contacts

Site Public Contact

515-956-4132

Principal Investigator:

Joseph J. Merchant

UI Health Care Mission Cancer and Blood - Waukee Clinic

Recruiting

Waukee, Iowa, United States, 50263

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Seema Harichand-Herdt

Methodist West Hospital

Recruiting

West Des Moines, Iowa, United States, 50266-7700

Contacts

Site Public Contact

515-343-1000

Principal Investigator:

Seema Harichand-Herdt

Mercy Medical Center-West Lakes

Recruiting

West Des Moines, Iowa, United States, 50266

Contacts

Site Public Contact

515-241-3305

Principal Investigator:

Richard L. Deming

Central Care Cancer Center - Garden City

Recruiting

Garden City, Kansas, United States, 67846

Contacts

Principal Investigator:

Jay W. Carlson

Central Care Cancer Center - Great Bend

Recruiting

Great Bend, Kansas, United States, 67530

Contacts

Principal Investigator:

Jay W. Carlson

Mercy Hospital Pittsburg

Recruiting

Pittsburg, Kansas, United States, 66762

Contacts

Site Public Contact

888-446-3729

Principal Investigator:

Jay W. Carlson

CommonSpirit Saint Joseph Hospital - Bardstown

Recruiting

Bardstown, Kentucky, United States, 40004

Contacts

Principal Investigator:

Shahzad Siddique

Commonwealth Cancer Center-Corbin

Recruiting

Corbin, Kentucky, United States, 40701

Contacts

Principal Investigator:

Shahzad Siddique

Saint Joseph Radiation Oncology Resource Center

Recruiting

Lexington, Kentucky, United States, 40504

Contacts

Principal Investigator:

Shahzad Siddique

CommonSpirit Saint Joseph Medical Center - East Lexington

Recruiting

Lexington, Kentucky, United States, 40509

Contacts

Principal Investigator:

Shahzad Siddique

CommonSpirit Saint Joseph Hospital London

Recruiting

London, Kentucky, United States, 40741

Contacts

Principal Investigator:

Shahzad Siddique

CommonSpirit Saint Joseph Hospital Mount Sterling

Recruiting

Mount Sterling, Kentucky, United States, 40353

Contacts

Principal Investigator:

Shahzad Siddique

Tufts Medical Center

Recruiting

Boston, Massachusetts, United States, 02111

Contacts

Principal Investigator:

Raymond L. Comenzo

Tufts Medical Center Cancer Center Stoneham

Recruiting

Stoneham, Massachusetts, United States, 02180

Contacts

Principal Investigator:

Raymond L. Comenzo

MyMichigan Medical Center Gratiot

Recruiting

Alma, Michigan, United States, 48801

Contacts

Principal Investigator:

Elie G. Dib

MyMichigan Medical Center Alpena

Recruiting

Alpena, Michigan, United States, 49707

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Recruiting

Ann Arbor, Michigan, United States, 48106

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Recruiting

Brighton, Michigan, United States, 48114

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health Medical Center - Brighton

Recruiting

Brighton, Michigan, United States, 48114

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health IHA Medical Group Hematology Oncology - Canton

Recruiting

Canton, Michigan, United States, 48188

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health Medical Center - Canton

Recruiting

Canton, Michigan, United States, 48188

Contacts

Principal Investigator:

Elie G. Dib

Chelsea Hospital

Recruiting

Chelsea, Michigan, United States, 48118

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Recruiting

Chelsea, Michigan, United States, 48118

Contacts

Principal Investigator:

Elie G. Dib

Hematology Oncology Consultants-Clarkston

Recruiting

Clarkston, Michigan, United States, 48346

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Health Saint John Hospital

Recruiting

Detroit, Michigan, United States, 48236

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford River District Hospital

Recruiting

East China Township, Michigan, United States, 48054

Contacts

Principal Investigator:

Elie G. Dib

OSF Saint Francis Hospital and Medical Group

Recruiting

Escanaba, Michigan, United States, 49829

Contacts

Principal Investigator:

Brian L. Burnette

Cancer Hematology Centers - Flint

Recruiting

Flint, Michigan, United States, 48503

Contacts

Principal Investigator:

Elie G. Dib

Genesee Hematology Oncology PC

Recruiting

Flint, Michigan, United States, 48503

Contacts

Principal Investigator:

Elie G. Dib

Genesys Hurley Cancer Institute

Recruiting

Flint, Michigan, United States, 48503

Contacts

Principal Investigator:

Elie G. Dib

Hurley Medical Center

Recruiting

Flint, Michigan, United States, 48503

Contacts

Principal Investigator:

Elie G. Dib

MyMichigan Medical Center Gladwin

Recruiting

Gladwin, Michigan, United States, 48624

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Saint John Hospital - Academic

Recruiting

Grosse Pointe Woods, Michigan, United States, 48236

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Saint John Hospital - Breast

Recruiting

Grosse Pointe Woods, Michigan, United States, 48236

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Saint John Hospital - Van Elslander

Recruiting

Grosse Pointe Woods, Michigan, United States, 48236

Contacts

Principal Investigator:

Elie G. Dib

University of Michigan Health - Sparrow Lansing

Recruiting

Lansing, Michigan, United States, 48912

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health Saint Mary Mercy Livonia Hospital

Recruiting

Livonia, Michigan, United States, 48154

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Saint John Hospital - Macomb Medical

Recruiting

Macomb, Michigan, United States, 48044

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Warren Hospital - Breast Macomb

Recruiting

Macomb, Michigan, United States, 48044

Contacts

Principal Investigator:

Elie G. Dib

MyMichigan Medical Center Midland

Recruiting

Midland, Michigan, United States, 48670

Contacts

Principal Investigator:

Elie G. Dib

MyMichigan Medical Center Mount Pleasant

Recruiting

Mount Pleasant, Michigan, United States, 48858

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Health Providence Novi Hospital

Recruiting

Novi, Michigan, United States, 48374

Contacts

Site Public Contact

248-849-5332kfife3@hfhs.org

Principal Investigator:

Adam M. Forman

Michigan Healthcare Professionals Pontiac

Recruiting

Pontiac, Michigan, United States, 48341

Contacts

Principal Investigator:

Elie G. Dib

Newland Medical Associates-Pontiac

Recruiting

Pontiac, Michigan, United States, 48341

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health Saint Joseph Mercy Oakland Hospital

Recruiting

Pontiac, Michigan, United States, 48341

Contacts

Principal Investigator:

Elie G. Dib

MyMichigan Medical Center Saginaw

Recruiting

Saginaw, Michigan, United States, 48601

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Health Providence Southfield Hospital

Recruiting

Southfield, Michigan, United States, 48075

Contacts

Site Public Contact

248-849-5332kfife3@hfhs.org

Principal Investigator:

Adam M. Forman

MyMichigan Medical Center Tawas

Recruiting

Tawas City, Michigan, United States, 48764

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Health Warren Hospital

Recruiting

Warren, Michigan, United States, 48093

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Madison Heights Hospital - Breast

Recruiting

Warren, Michigan, United States, 48093

Contacts

Principal Investigator:

Elie G. Dib

Henry Ford Warren Hospital - GLCMS

Recruiting

Warren, Michigan, United States, 48093

Contacts

Principal Investigator:

Elie G. Dib

Huron Gastroenterology PC

Recruiting

Ypsilanti, Michigan, United States, 48106

Contacts

Principal Investigator:

Elie G. Dib

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Recruiting

Ypsilanti, Michigan, United States, 48197

Contacts

Principal Investigator:

Elie G. Dib

Minnesota Oncology - Burnsville

Recruiting

Burnsville, Minnesota, United States, 55337

Contacts

Principal Investigator:

David M. King

Cambridge Medical Center

Recruiting

Cambridge, Minnesota, United States, 55008

Contacts

Principal Investigator:

David M. King

Minnesota Oncology Hematology PA-Chaska

Recruiting

Chaska, Minnesota, United States, 55318

Contacts

Principal Investigator:

David M. King

Mercy Hospital

Recruiting

Coon Rapids, Minnesota, United States, 55433

Contacts

Principal Investigator:

David M. King

Minnesota Oncology - Coon Rapids

Recruiting

Coon Rapids, Minnesota, United States, 55433

Contacts

Principal Investigator:

David M. King

Fairview Southdale Hospital

Recruiting

Edina, Minnesota, United States, 55435

Contacts

Principal Investigator:

David M. King

Minnesota Oncology - Edina

Recruiting

Edina, Minnesota, United States, 55435

Contacts

Principal Investigator:

David M. King

Fairview Clinics and Surgery Center Maple Grove

Recruiting

Maple Grove, Minnesota, United States, 55369

Contacts

Principal Investigator:

David M. King

Minnesota Oncology - Maple Grove

Recruiting

Maple Grove, Minnesota, United States, 55369

Contacts

Principal Investigator:

David M. King

Minnesota Oncology Hematology PA-Maplewood

Recruiting

Maplewood, Minnesota, United States, 55109

Contacts

Principal Investigator:

David M. King

Saint John's Hospital - Healtheast

Recruiting

Maplewood, Minnesota, United States, 55109

Contacts

Principal Investigator:

David M. King

Abbott-Northwestern Hospital

Recruiting

Minneapolis, Minnesota, United States, 55407

Contacts

Principal Investigator:

David M. King

Hennepin County Medical Center

Recruiting

Minneapolis, Minnesota, United States, 55415

Contacts

Principal Investigator:

David M. King

Monticello Cancer Center

Recruiting

Monticello, Minnesota, United States, 55362

Contacts

Principal Investigator:

David M. King

New Ulm Medical Center

Recruiting

New Ulm, Minnesota, United States, 56073

Contacts

Principal Investigator:

David M. King

Fairview Northland Medical Center

Recruiting

Princeton, Minnesota, United States, 55371

Contacts

Principal Investigator:

David M. King

North Memorial Medical Health Center

Recruiting

Robbinsdale, Minnesota, United States, 55422

Contacts

Principal Investigator:

David M. King

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Site Public Contact

855-776-0015

Principal Investigator:

Shaji K. Kumar

Park Nicollet Clinic - Saint Louis Park

Recruiting

Saint Louis Park, Minnesota, United States, 55416

Contacts

Principal Investigator:

David M. King

Regions Hospital

Recruiting

Saint Paul, Minnesota, United States, 55101

Contacts

Principal Investigator:

David M. King

United Hospital

Recruiting

Saint Paul, Minnesota, United States, 55102

Contacts

Principal Investigator:

David M. King

Saint Francis Regional Medical Center

Recruiting

Shakopee, Minnesota, United States, 55379

Contacts

Principal Investigator:

David M. King

Lakeview Hospital

Recruiting

Stillwater, Minnesota, United States, 55082

Contacts

Principal Investigator:

David M. King

Ridgeview Medical Center

Recruiting

Waconia, Minnesota, United States, 55387

Contacts

Principal Investigator:

David M. King

Rice Memorial Hospital

Recruiting

Willmar, Minnesota, United States, 56201

Contacts

Principal Investigator:

David M. King

Minnesota Oncology Hematology PA-Woodbury

Recruiting

Woodbury, Minnesota, United States, 55125

Contacts

Principal Investigator:

David M. King

Fairview Lakes Medical Center

Recruiting

Wyoming, Minnesota, United States, 55092

Contacts

Principal Investigator:

David M. King

Gulfport Memorial Hospital

Recruiting

Gulfport, Mississippi, United States, 39502

Contacts

Principal Investigator:

Augusto C. Ochoa

Mercy Oncology and Hematology - Clayton-Clarkson

Recruiting

Ballwin, Missouri, United States, 63011

Contacts

Site Public Contact

888-446-3729

Principal Investigator:

Jay W. Carlson

Central Care Cancer Center - Bolivar

Recruiting

Bolivar, Missouri, United States, 65613

Contacts

Principal Investigator:

Jay W. Carlson

Cox Cancer Center Branson

Recruiting

Branson, Missouri, United States, 65616

Contacts

Site Public Contact

417-269-4520

Principal Investigator:

Jay W. Carlson

Mercy Cancer Center - Cape Girardeau

Recruiting

Cape Girardeau, Missouri, United States, 63703

Contacts

Site Public Contact

888-446-3729

Principal Investigator:

Jay W. Carlson

Saint Francis Medical Center

Recruiting

Cape Girardeau, Missouri, United States, 63703

Contacts

Site Public Contact

573-334-2230sfmc@sfmc.net

Principal Investigator:

Bryan A. Faller

Parkland Health Center - Farmington

Recruiting

Farmington, Missouri, United States, 63640

Contacts

Site Public Contact

314-996-5569

Principal Investigator:

Bryan A. Faller

Freeman Health System

Recruiting

Joplin, Missouri, United States, 64804

Contacts

Principal Investigator:

Jay W. Carlson

Mercy Hospital Joplin

Recruiting

Joplin, Missouri, United States, 64804

Contacts

Principal Investigator:

Jay W. Carlson

Kansas City Veterans Affairs Medical Center

Recruiting

Kansas City, Missouri, United States, 64128

Contacts

Site Public Contact

800-525-1483

Principal Investigator:

Suman Kambhampati

Lake Regional Hospital

Recruiting

Osage Beach, Missouri, United States, 65065

Contacts

Principal Investigator:

Jay W. Carlson

Mercy Clinic-Rolla-Cancer and Hematology

Recruiting

Rolla, Missouri, United States, 65401

Contacts

Site Public Contact

573-458-6379

Principal Investigator:

Jay W. Carlson

Phelps Health Delbert Day Cancer Institute

Recruiting

Rolla, Missouri, United States, 65401

Contacts

Principal Investigator:

Jay W. Carlson

Heartland Regional Medical Center

Recruiting

Saint Joseph, Missouri, United States, 64506

Contacts

Principal Investigator:

Jay W. Carlson

Sainte Genevieve County Memorial Hospital

Recruiting

Sainte Genevieve, Missouri, United States, 63670

Contacts

Site Public Contact

314-996-5569

Principal Investigator:

Bryan A. Faller

Mercy Hospital Springfield

Recruiting

Springfield, Missouri, United States, 65804

Contacts

Site Public Contact

417-269-4520

Principal Investigator:

Jay W. Carlson

CoxHealth South Hospital

Recruiting

Springfield, Missouri, United States, 65807

Contacts

Site Public Contact

417-269-4520

Principal Investigator:

Jay W. Carlson

Mercy Infusion Center - Chippewa

Recruiting

St Louis, Missouri, United States, 63109

Contacts

Site Public Contact

888-446-3729

Principal Investigator:

Jay W. Carlson

Mercy Hospital South

Recruiting

St Louis, Missouri, United States, 63128

Contacts

Principal Investigator:

Jay W. Carlson

Missouri Baptist Medical Center

Recruiting

St Louis, Missouri, United States, 63131

Contacts

Site Public Contact

314-996-5569

Principal Investigator:

Bryan A. Faller

Mercy Hospital Saint Louis

Recruiting

St Louis, Missouri, United States, 63141

Contacts

Site Public Contact

314-251-7066

Principal Investigator:

Jay W. Carlson

Missouri Baptist Sullivan Hospital

Recruiting

Sullivan, Missouri, United States, 63080

Contacts

Site Public Contact

314-996-5569

Principal Investigator:

Bryan A. Faller

Mercy Hospital Washington

Recruiting

Washington, Missouri, United States, 63090

Contacts

Site Public Contact

636-390-1600

Principal Investigator:

Jay W. Carlson

Saint Patrick Hospital - Community Hospital

Recruiting

Missoula, Montana, United States, 59802

Contacts

Principal Investigator:

Alison K. Conlin

CHI Health Saint Francis

Recruiting

Grand Island, Nebraska, United States, 68803

Contacts

Principal Investigator:

Shahzad Siddique

CHI Health Good Samaritan

Recruiting

Kearney, Nebraska, United States, 68847

Contacts

Principal Investigator:

Shahzad Siddique

Alegent Health Immanuel Medical Center

Recruiting

Omaha, Nebraska, United States, 68122

Contacts

Principal Investigator:

Shahzad Siddique

Alegent Health Bergan Mercy Medical Center

Recruiting

Omaha, Nebraska, United States, 68124

Contacts

Principal Investigator:

Shahzad Siddique

Alegent Health Lakeside Hospital

Recruiting

Omaha, Nebraska, United States, 68130

Contacts

Principal Investigator:

Shahzad Siddique

Jefferson Cherry Hill Hospital

Recruiting

Cherry Hill, New Jersey, United States, 08002

Contacts

Principal Investigator:

Adam F. Binder

Sidney Kimmel Cancer Center Washington Township

Recruiting

Sewell, New Jersey, United States, 08080

Contacts

Principal Investigator:

Adam F. Binder

University of Rochester

Recruiting

Rochester, New York, United States, 14642

Contacts

Site Public Contact

585-275-5830

Principal Investigator:

Brea C. Lipe

State University of New York Upstate Medical University

Recruiting

Syracuse, New York, United States, 13210

Contacts

Site Public Contact

315-464-5476

Principal Investigator:

Krishna Ghimire

Upstate Cancer Center at Verona

Recruiting

Verona, New York, United States, 13478

Contacts

Principal Investigator:

Krishna Ghimire

Southeastern Medical Oncology Center-Clinton

Recruiting

Clinton, North Carolina, United States, 28328

Contacts

Principal Investigator:

Samer S. Kasbari

Southeastern Medical Oncology Center-Goldsboro

Recruiting

Goldsboro, North Carolina, United States, 27534

Contacts

Principal Investigator:

Samer S. Kasbari

Southeastern Medical Oncology Center-Jacksonville

Recruiting

Jacksonville, North Carolina, United States, 28546

Contacts

Principal Investigator:

Samer S. Kasbari

OhioHealth O'Bleness Hospital

Recruiting

Athens, Ohio, United States, 45701

Contacts

Principal Investigator:

Yvonne A. Efebera

Good Samaritan Hospital - Cincinnati

Recruiting

Cincinnati, Ohio, United States, 45220

Contacts

Principal Investigator:

Shahzad Siddique

Bethesda North Hospital

Recruiting

Cincinnati, Ohio, United States, 45242

Contacts

Principal Investigator:

Shahzad Siddique

TriHealth Cancer Institute-Westside

Recruiting

Cincinnati, Ohio, United States, 45247

Contacts

Principal Investigator:

Shahzad Siddique

TriHealth Cancer Institute-Anderson

Recruiting

Cincinnati, Ohio, United States, 45255

Contacts

Principal Investigator:

Shahzad Siddique

MetroHealth Medical Center

Recruiting

Cleveland, Ohio, United States, 44109

Contacts

Principal Investigator:

Tamila L. Kindwall-Keller

Columbus Oncology and Hematology Associates Inc

Recruiting

Columbus, Ohio, United States, 43214

Contacts

Principal Investigator:

Yvonne A. Efebera

Riverside Methodist Hospital

Recruiting

Columbus, Ohio, United States, 43214

Contacts

Principal Investigator:

Yvonne A. Efebera

Grant Medical Center

Recruiting

Columbus, Ohio, United States, 43215

Contacts

Principal Investigator:

Yvonne A. Efebera

Doctors Hospital

Recruiting

Columbus, Ohio, United States, 43228

Contacts

Principal Investigator:

Yvonne A. Efebera

Delaware Health Center-Grady Cancer Center

Recruiting

Delaware, Ohio, United States, 43015

Contacts

Principal Investigator:

Yvonne A. Efebera

Grady Memorial Hospital

Recruiting

Delaware, Ohio, United States, 43015

Contacts

Principal Investigator:

Yvonne A. Efebera

Columbus Oncology and Hematology Associates

Recruiting

Dublin, Ohio, United States, 43016

Contacts

Principal Investigator:

Yvonne A. Efebera

Dublin Methodist Hospital

Recruiting

Dublin, Ohio, United States, 43016

Contacts

Principal Investigator:

Yvonne A. Efebera

OhioHealth Mansfield Hospital

Recruiting

Mansfield, Ohio, United States, 44903

Contacts

Principal Investigator:

Yvonne A. Efebera

OhioHealth Marion General Hospital

Recruiting

Marion, Ohio, United States, 43302

Contacts

Principal Investigator:

Yvonne A. Efebera

OhioHealth Pickerington Methodist Hospital

Recruiting

Pickerington, Ohio, United States, 43147

Contacts

Principal Investigator:

Yvonne A. Efebera

OhioHealth Westerville Medical Campus/Westerville Cancer Center

Recruiting

Westerville, Ohio, United States, 43082

Contacts

Principal Investigator:

Yvonne A. Efebera

Mercy Hospital Oklahoma City

Recruiting

Oklahoma City, Oklahoma, United States, 73120

Contacts

Site Public Contact

405-752-3402

Principal Investigator:

Jay W. Carlson

Saint Alphonsus Cancer Care Center-Baker City

Recruiting

Baker City, Oregon, United States, 97814

Contacts

Principal Investigator:

Elie G. Dib

Saint Alphonsus Cancer Care Center-Ontario

Recruiting

Ontario, Oregon, United States, 97914

Contacts

Principal Investigator:

Elie G. Dib

Lehigh Valley Hospital-Cedar Crest

Recruiting

Allentown, Pennsylvania, United States, 18103

Contacts

Principal Investigator:

Elie G. Dib

Lehigh Valley Hospital - Muhlenberg

Recruiting

Bethlehem, Pennsylvania, United States, 18017

Contacts

Principal Investigator:

Elie G. Dib

Pocono Medical Center

Recruiting

East Stroudsburg, Pennsylvania, United States, 18301

Contacts

Principal Investigator:

Elie G. Dib

Penn State Health Medical Group - Andrews Patel Hematology/Oncology East

Recruiting

Harrisburg, Pennsylvania, United States, 17111

Contacts

Site Public Contact

717-526-1030

Principal Investigator:

Shin Mineishi

Lehigh Valley Hospital-Hazleton

Recruiting

Hazleton, Pennsylvania, United States, 18201

Contacts

Principal Investigator:

Elie G. Dib

Thomas Jefferson University Hospital

Recruiting

Philadelphia, Pennsylvania, United States, 19107

Contacts

Principal Investigator:

Adam F. Binder

Smilow Cancer Hospital Care Center - Westerly

Recruiting

Westerly, Rhode Island, United States, 02891

Contacts

Principal Investigator:

Sabrina Browning

Ralph H Johnson VA Medical Center

Recruiting

Charleston, South Carolina, United States, 29401

Contacts

Principal Investigator:

Oleksandra Lupak

Rapid City Regional Hospital

Recruiting

Rapid City, South Dakota, United States, 57701

Contacts

Principal Investigator:

Abdel-Ghani Azzouqa

University of Vermont Medical Center

Recruiting

Burlington, Vermont, United States, 05401

Contacts

Site Public Contact

802-656-4101rpo@uvm.edu

Principal Investigator:

Mansour Gergi

University of Vermont and State Agricultural College

Recruiting

Burlington, Vermont, United States, 05405

Contacts

Site Public Contact

802-656-8990rpo@uvm.edu

Principal Investigator:

Mansour Gergi

White River Junction Veteran Administration Medical Center

Recruiting

White River Junction, Vermont, United States, 05009

Contacts

Site Public Contact

866-687-8387

Principal Investigator:

Britt H. Olmsted

Saint Joseph Medical Center Hematology and Oncology - Silverdale

Recruiting

Silverdale, Washington, United States, 98383

Contacts

Principal Investigator:

Shahzad Siddique

ThedaCare Regional Cancer Center

Recruiting

Appleton, Wisconsin, United States, 54911

Contacts

Principal Investigator:

Yazhini Vallatharasu

Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton

Recruiting

Appleton, Wisconsin, United States, 54915

Contacts

Site Public Contact

AWRI.inquiry@ascension.org

Principal Investigator:

Jonathan S. Treisman

Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield

Recruiting

Brookfield, Wisconsin, United States, 53045

Contacts

Site Public Contact

AWRI.Inquiry@Ascension.org

Principal Investigator:

Jonathan S. Treisman

Aurora Cancer Care-Southern Lakes VLCC

Recruiting

Burlington, Wisconsin, United States, 53105

Contacts

Principal Investigator:

Thomas J. Saphner

Ascension Calumet Hospital-Chilton

Recruiting

Chilton, Wisconsin, United States, 53014

Contacts

Site Public Contact

AWRI.inquiry@ascension.org

Principal Investigator:

Jonathan S. Treisman

Marshfield Clinic-Chippewa Center

Recruiting

Chippewa Falls, Wisconsin, United States, 54729

Contacts

Principal Investigator:

Adedayo A. Onitilo

Aurora Saint Luke's South Shore

Recruiting

Cudahy, Wisconsin, United States, 53110

Contacts

Principal Investigator:

Thomas J. Saphner

Marshfield Medical Center-EC Cancer Center

Recruiting

Eau Claire, Wisconsin, United States, 54701

Contacts

Principal Investigator:

Adedayo A. Onitilo

Ascension Southeast Wisconsin Hospital - Franklin

Recruiting

Franklin, Wisconsin, United States, 53132

Contacts

Site Public Contact

AWRI.Inquiry@Ascension.org

Principal Investigator:

Jonathan S. Treisman

Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson

Recruiting

Franklin, Wisconsin, United States, 53132

Contacts

Site Public Contact

AWRI.Inquiry@Ascension.org

Principal Investigator:

Jonathan S. Treisman

Aurora Health Care Germantown Health Center

Recruiting

Germantown, Wisconsin, United States, 53022

Contacts

Principal Investigator:

Thomas J. Saphner

Aurora Cancer Care-Grafton

Recruiting

Grafton, Wisconsin, United States, 53024

Contacts

Principal Investigator:

Thomas J. Saphner

Saint Vincent Hospital Cancer Center Green Bay

Recruiting

Green Bay, Wisconsin, United States, 54301

Contacts

Principal Investigator:

Brian L. Burnette

Saint Vincent Hospital Cancer Center at Saint Mary's

Recruiting

Green Bay, Wisconsin, United States, 54303

Contacts

Principal Investigator:

Brian L. Burnette

Aurora BayCare Medical Center

Recruiting

Green Bay, Wisconsin, United States, 54311

Contacts

Principal Investigator:

Thomas J. Saphner

Aurora Cancer Care-Kenosha South

Recruiting

Kenosha, Wisconsin, United States, 53142

Contacts

Principal Investigator:

Thomas J. Saphner

Gundersen Lutheran Medical Center

Recruiting

La Crosse, Wisconsin, United States, 54601

Contacts

Principal Investigator:

Kurt Oettel

Marshfield Medical Center - Ladysmith

Recruiting

Ladysmith, Wisconsin, United States, 54848

Contacts

Principal Investigator:

Adedayo A. Onitilo

William S Middleton VA Medical Center

Recruiting

Madison, Wisconsin, United States, 53705

Contacts

Site Public Contact

608-256-1901

Principal Investigator:

Christopher D. Fletcher

University of Wisconsin Carbone Cancer Center - University Hospital

Recruiting

Madison, Wisconsin, United States, 53792

Contacts

Principal Investigator:

Timothy M. Schmidt

Aurora Bay Area Medical Group-Marinette

Recruiting

Marinette, Wisconsin, United States, 54143

Contacts

Principal Investigator:

Thomas J. Saphner

Marshfield Medical Center-Marshfield

Recruiting

Marshfield, Wisconsin, United States, 54449

Contacts

Principal Investigator:

Adedayo A. Onitilo

Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon

Recruiting

Mequon, Wisconsin, United States, 53097

Contacts

Site Public Contact

AWRI.Inquiry@Ascension.org

Principal Investigator:

Jonathan S. Treisman

Aurora Cancer Care-Milwaukee

Recruiting

Milwaukee, Wisconsin, United States, 53209

Contacts

Principal Investigator:

Thomas J. Saphner

Ascension Southeast Wisconsin Hospital-Saint Joseph-Milwaukee

Recruiting

Milwaukee, Wisconsin, United States, 53210

Contacts

Principal Investigator:

Jonathan S. Treisman

Ascension Columbia Saint Mary's Hospital-Milwaukee Campus

Recruiting

Milwaukee, Wisconsin, United States, 53211

Contacts

Site Public Contact

AWRI.Inquiry@Ascension.org

Principal Investigator:

Jonathan S. Treisman

Ascension Saint Francis Hospital-Milwaukee

Recruiting

Milwaukee, Wisconsin, United States, 53215

Contacts

Site Public Contact

AWRI.Inquiry@Ascension.org

Principal Investigator:

Jonathan S. Treisman

Aurora Saint Luke's Medical Center

Recruiting

Milwaukee, Wisconsin, United States, 53215

Contacts

Principal Investigator:

Thomas J. Saphner

Aurora Sinai Medical Center

Recruiting

Milwaukee, Wisconsin, United States, 53233

Contacts

Principal Investigator:

Thomas J. Saphner

Marshfield Medical Center - Minocqua

Recruiting

Minocqua, Wisconsin, United States, 54548

Contacts

Principal Investigator:

Adedayo A. Onitilo

ThedaCare Regional Medical Center - Neenah

Recruiting

Neenah, Wisconsin, United States, 54956

Contacts

Principal Investigator:

Yazhini Vallatharasu

Marshfield Medical Center - Neillsville

Recruiting

Neillsville, Wisconsin, United States, 54456

Contacts

Principal Investigator:

Adedayo A. Onitilo

Cancer Center of Western Wisconsin

Recruiting

New Richmond, Wisconsin, United States, 54017

Contacts

Principal Investigator:

David M. King

Saint Vincent Hospital Cancer Center at Oconto Falls

Recruiting

Oconto Falls, Wisconsin, United States, 54154

Contacts

Principal Investigator:

Brian L. Burnette

Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh

Recruiting

Oshkosh, Wisconsin, United States, 54904

Contacts

Site Public Contact

AWRI.inquiry@ascension.org

Principal Investigator:

Jonathan S. Treisman

Vince Lombardi Cancer Clinic - Oshkosh

Recruiting

Oshkosh, Wisconsin, United States, 54904

Contacts

Principal Investigator:

Thomas J. Saphner

Ascension All Saints Hospital-Spring Street-Racine

Recruiting

Racine, Wisconsin, United States, 53405

Contacts

Site Public Contact

AWRI.Inquiry@Ascension.org

Principal Investigator:

Jonathan S. Treisman

Aurora Cancer Care-Racine

Recruiting

Racine, Wisconsin, United States, 53406

Contacts

Principal Investigator:

Thomas J. Saphner

Marshfield Medical Center-Rice Lake

Recruiting

Rice Lake, Wisconsin, United States, 54868

Contacts

Principal Investigator:

Adedayo A. Onitilo

Vince Lombardi Cancer Clinic-Sheboygan

Recruiting

Sheboygan, Wisconsin, United States, 53081

Contacts

Principal Investigator:

Thomas J. Saphner

Marshfield Medical Center-River Region at Stevens Point

Recruiting

Stevens Point, Wisconsin, United States, 54482

Contacts

Principal Investigator:

Adedayo A. Onitilo

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Recruiting

Sturgeon Bay, Wisconsin, United States, 54235-1495

Contacts

Principal Investigator:

Brian L. Burnette

Aurora Medical Center in Summit

Recruiting

Summit, Wisconsin, United States, 53066

Contacts

Principal Investigator:

Thomas J. Saphner

Vince Lombardi Cancer Clinic-Two Rivers

Recruiting

Two Rivers, Wisconsin, United States, 54241

Contacts

Principal Investigator:

Thomas J. Saphner

Marshfield Clinic-Wausau Center

Recruiting

Wausau, Wisconsin, United States, 54401

Contacts

Principal Investigator:

Adedayo A. Onitilo

Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa

Recruiting

Wauwatosa, Wisconsin, United States, 53226

Contacts

Site Public Contact

AWRI.Inquiry@Ascension.org

Principal Investigator:

Jonathan S. Treisman

Aurora Cancer Care-Milwaukee West

Recruiting

Wauwatosa, Wisconsin, United States, 53226

Contacts

Principal Investigator:

Thomas J. Saphner

Aurora West Allis Medical Center

Recruiting

West Allis, Wisconsin, United States, 53227

Contacts

Principal Investigator:

Thomas J. Saphner

Marshfield Medical Center - Weston

Recruiting

Weston, Wisconsin, United States, 54476

Contacts

Principal Investigator:

Adedayo A. Onitilo

Marshfield Clinic - Wisconsin Rapids Center

Recruiting

Wisconsin Rapids, Wisconsin, United States, 54494

Contacts

Principal Investigator:

Adedayo A. Onitilo

More Information

Sponsor

ECOG-ACRIN Cancer Research Group

Last update posted

Aug 19, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-17. This information was provided to ClinicalTrials.gov by ECOG-ACRIN Cancer Research Group on 2026-08-19.