Recruiting

Loneliness Investigation

Sponsor:

Columbia University

Code:

NCT04577911

Conditions

Loneliness

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Interventions

Basic Science Experiment

Study Details

Brief summary:

Nearly half of the U.S. population sometimes or always experiences loneliness, which is alarming given that loneliness confers risk for negative mental and physical health outcomes. Extensive research suggests loneliness is characterized by subjective isolation: many lonely individuals maintain a number of relationships but still report feeling lonely. The goal of this proposal is to use functional magnetic resonance imaging to reveal how the brain represents our subjective connection to and isolation from other people, which will ultimately inform optimal ways to intervene to reduce loneliness.

Conditions

Loneliness

Study ID

NCT04577911

Start date

Apr 1, 2021

Status verified date

Dec, 2025

Completion date

Nov, 2026

Anticipated

Primary completion date

Nov, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Inclusion Criteria:

  • safe for MRI scanning
  • not taking psychiatric medication

Exclusion Criteria:

  • not safe for MRI scanning
  • taking psychiatric medication

Study Design

Enrollment

248 participants

Anticipated

Interventions and Outcome Measures

Interventions

Basic Science Experiment

participants complete cognitive tasks while undergoing functional magnetic resonance imaging (fMRI)

Primary outcome measure

  • Blood Oxygenated-Level Dependent (BOLD) Response [ Time Frame: 2 hours ]

Central Contacts and Locations

Central contacts

Locations

Columbia University Irving Medical Center

Recruiting

New York, New York, United States, 10032

Contacts

Meghan L Meyer, PhD

650-521-1701

More Information

Sponsor

Columbia University

Last update posted

Dec 16, 2025

Last verified

Dec, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Columbia University on 2025-12-16.