Recruiting

Partial Wrist Fusion

Sponsor:

University of Alberta

Code:

NCT04580225

Conditions

Wrist Arthritis

Wrist Arthropathy

Scapholunate Advanced Collapse

Scaphoid Nonunion

Post-traumatic; Arthrosis

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Four-Corner Arthrodesis

Three-Corner or Capitolunate Arthrodesis with Triquetral Excision

Study Details

Brief summary:

This randomized clinical trial (RCT) aims to compare clinical and radiographic outcomes of different partial wrist fusion techniques in participants with post-traumatic wrist arthritis. Participants with stage II or III scapholunate advanced collapse (SLAC) or scaphoid nonunion advanced collapse (SNAC) who meet the eligibility criteria will be randomly assigned to one of two parallel groups: Group A (partial wrist arthrodesis without triquetral excision i.e. four-corner arthrodesis), or Group B (partial wrist arthrodesis with triquetral excision i.e. three-corner or capitolunate arthrodesis with triquetral excision). The results of this study will provide evidence to guide surgeons in determining the ideal wrist fusion technique in the management of patients with post-traumatic wrist arthritis requiring surgery.

Conditions

Wrist Arthritis

Wrist Arthropathy

Scapholunate Advanced Collapse

Scaphoid Nonunion

Post-traumatic; Arthrosis

Study ID

NCT04580225

Start date

Jan 7, 2021

Status verified date

Jun, 2026

Completion date

Apr, 2027

Anticipated

Primary completion date

Apr, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Participant has a stage II or III scapholunate advanced collapse (SLAC) or scaphoid nonunion advanced collapse (SNAC) wrist and is a surgical candidate for the included surgical interventions

Exclusion Criteria:

  • Participant has been diagnosed with other forms of wrist arthritis other than SLAC or SNAC
  • Participant has significant arthritis of the ipsilateral hand/finger joint(s), major joint trauma, previous major wrist surgery, infection or neuromuscular pathology affecting the function of the ipsilateral upper extremity or ability to make a fist
  • Participant has a physical or mental health condition preventing completion of consent or questionnaires
  • Participant does not speak/read/understand English
  • Participant has no fixed address or means of contact
  • Participant is unwilling to complete necessary follow-ups
  • Surgeon concludes that eligible salvage techniques are not appropriate at the time of surgery (based on injury characteristics or concomitant wrist pathology)

Study Design

Enrollment

170 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Group A: Partial Wrist Arthrodesis without Triquetral Excision

Four-Corner Arthrodesis

active comparator: Group B: Partial Wrist Arthrodesis with Triquetral Excision

Three-Corner or Capitolunate Arthrodesis with Triquetral Excision

Interventions

Four-Corner Arthrodesis

Participants in Group A will receive a four-corner arthrodesis (fusion of the capitate, hamate, lunate, and triquetrum) with excision of the scaphoid.

Three-Corner or Capitolunate Arthrodesis with Triquetral Excision

Participants in Group B will receive a three-corner arthrodesis (fusion of the capitate, hamate, and lunate) or capitolunate arthrodesis (fusion of the capitate and lunate) with excision of the scaphoid and triquetrum.

Primary outcome measure

  • Grip Strength [ Time Frame: Completed at baseline (pre-surgery), 3-, 6-, 12-months post-surgery ]

Central Contacts and Locations

Central contacts

Dr. Armin Badre, MD, MSc, FRCSC

(780) 569-5494badre@ualberta.ca

Collaborative Orthopaedic Research (CORe)

(780) 492-0830

Locations

South Health Campus

Recruiting

Calgary, Alberta, Canada

Contacts

Sara Kayvani

403-956-3687sara.kayvani@ucalgary.ca

Principal Investigator:

Neil White, MD, FRCSC

Western Hand & Upper Limb Facility, Sturgeon Community Hospital

Recruiting

St. Albert, Alberta, Canada

Contacts

Research Coordinator, Sturgeon Community Hospital

(780) 418-7410

Principal Investigator:

Armin Badre, MD, MSc, FRCSC

Lawson Health Research Institute

Recruiting

London, Ontario, Canada

Contacts

Katrina Munro

katrina.munro@sjhc.london.on.ca

Principal Investigator:

Ruby Grewal, MD, FRCSC

The Ottawa Hospital - Civic Campus

Recruiting

Ottawa, Ontario, Canada

Contacts

Hoda Ghaziasgar, MSc

613-737-8899hghaziasgar@ohri.ca

Principal Investigator:

Manisha Mistry, MD, MSc, FRCSC

University of Saskatchewan

Recruiting

Saskatoon, Saskatchewan, Canada

Contacts

Laura A. Sims, MD, FRCSC

laurasims710@gmail.com

Principal Investigator:

Laura A. Sims, MD, FRCSC

More Information

Sponsor

University of Alberta

Last update posted

Jun 24, 2026

Last verified

Jun, 2026

Keywords

  • Post-traumatic wrist arthritis
  • Partial wrist fusions
  • Scapholunate advanced collapse
  • SLAC wrist
  • Scaphoid nonunion advanced collapse
  • SNAC wrist
  • Four-corner fusion
  • Bicolumnar wrist fusion
  • Three-corner fusion
  • Capitolunate fusion

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Alberta on 2026-06-24.