Recruiting

Lung Ultrasound

Sponsor:

Mayo Clinic

Code:

NCT04582279

Conditions

Post-Lung Transplantation Bronchiectasis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Lung ultrasound

Study Details

Brief summary:

This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Conditions

Post-Lung Transplantation Bronchiectasis

Study ID

NCT04582279

Start date

Oct 28, 2020

Status verified date

Feb, 2026

Completion date

Dec 30, 2026

Anticipated

Primary completion date

Oct 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adult patients (> 18 yrs) who had undergone single/double/heart-lung transplant
  • Asymptomatic
  • Normal spirometry defined as a FEV1 without significant drop from baseline (significant drop = >10% decrease from baseline)
  • Clear chest radiograph over allograft

Exclusion Criteria:

  • Patients who are unable to consent for the procedure
  • Patients with subcutaneous emphysema or other technical challenges that could interfere with satisfactory image acquisition- as deemed by the operator.

Study Design

Enrollment

90 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Receiving Ultrasound

Every patient will receive a lung ultrasound prior to each scheduled bronchoscopy until the study stops.

Interventions

Lung ultrasound

The lung ultrasound will be performed by a trained pulmonologist by gently pressing a probe to various areas of your chest. This is a non-invasive procedure and you should not feel any pain. The ultrasound will take less than 10 minutes.

Primary outcome measure

  • Establish predictive value of lung ultrasound [ Time Frame: Month 0 to month 12 ]

Central Contacts and Locations

Locations

Mayo Clinic in Florida

Recruiting

Jacksonville, Florida, United States, 32224

Contacts

Neha Shukla

904-953-3966shukla.neha@mayo.edu

More Information

Sponsor

Mayo Clinic

Last update posted

Feb 5, 2026

Last verified

Feb, 2026

Keywords

  • Post lung transplant
  • Lung bronchoscopy
  • Lung biopsy
  • Lung rejection

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-02-05.