Recruiting

Observational Study

Sponsor:

National Cancer Institute (NCI)

Code:

NCT04609072

Conditions

Cancer

General Research Use

Eligibility Criteria

Sex: All

Age: 30 - 70

Healthy Volunteers: Accepted

Study Details

Brief summary:

Background:

The National Cancer Institute, part of the National Institutes of Health, has partnered with nine health care systems across the U.S. to establish the Connect for Cancer Prevention Study. While researchers have made important discoveries, there is more to learn to lower the number of people affected by cancer. By taking part in Connect, participants can help researchers learn how the way we live, our genetics, and our health history may affect cancer risk.

Objective:

To study and better understand the causes of cancer and to find new ways to prevent it.

Eligibility:

The study will include 200,000 adults who get their health care from a partner health care system, are between 30 and 70 years old at enrollment, and have never had cancer. People remain eligible to join if they have or once had non-melanoma skin cancer, or a condition that may raise cancer risk (such as ductal carcinoma in situ, or DCIS).

Design:

Eligible recruits can sign up for Connect online by creating an account on MyConnect using their email address or phone number. After creating an account, they will complete the informed consent process. All information shared through MyConnect is secure to protect participant privacy. After joining the study, participants will be asked to answer online health surveys a few times a year, donate samples of blood, urine, and saliva every two to three years, and safely share access to their electronic health records with Connect. In the future, participants may donate unused samples that are collected at clinical visits, like tissue, stool, or blood, and may mail in samples collected at home. Participants may also share information from personal health trackers, like wearable devices or apps.

This information will help researchers study the health and behavior patterns that may affect cancer risk.

It takes time to understand the causes of cancer, so Connect will go on for many years. The longer people participate, the more researchers may learn. Participants can leave the study at any time.

Learn more about Connect by visiting cancer.gov/connectstudy.

Conditions

Cancer

General Research Use

Study ID

NCT04609072

Start date

Jul 26, 2021

Status verified date

Aug 18, 2026

Completion date

Dec 31, 2070

Anticipated

Primary completion date

Dec 31, 2070

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 30 - 70

Healthy Volunteers: Accepted

  • INCLUSION CRITERIA:

Due to the minimal risk nature of this protocol, all individuals interested and able to participate in Connect for Cancer Prevention, who meet the eligibility criteria at time of initial study invitation, will be able to participate. In order to be eligible to participate in this study, an individual must meet all of the following criteria:

  • Patients or members of participating IHCS at the time of enrollment
  • Age between 30 and 70 years old at study invitation

If an individual is determined to be ineligible at the time of enrollment due to age, the individual will be allowed to re-enroll at a later time once the recruit meets the age requirement. This includes recruits that did not meet the original age requirement of 40-65 years of age but now meet the updated age range of 30-70.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria at time of initial study invitation will be excluded from participation in this study:

  • Individuals with a confirmed history of invasive cancer (other than non-melanoma skin cancer)
  • Individuals with known cognitive impairment documented in their medical record

Study Design

Enrollment

200000 participants

Anticipated

Interventions and Outcome Measures

Arms

Healthy volunteers

Up to 200,000 men and women aged 30 to 70 years, with no personal history of cancer, and patients or members of participating integrated health care systems.

Primary outcome measure

  • cancer incidence, progression, and mortality [ Time Frame: year one and onward ]

Central Contacts and Locations

Central contacts

Nicolas A Wentzensen, M.D.

(866) 462-6621ConnectPI@nih.gov

Locations

Kaiser Permanente Colorado

Recruiting

Denver, Colorado, United States, 80247

Kaiser Permanente Georgia

Recruiting

Atlanta, Georgia, United States, 30305

Kaiser Permanente Hawaii

Recruiting

Honolulu, Hawaii, United States, 96814

Henry Ford Health Systems

Recruiting

Detroit, Michigan, United States, 48202

HealthPartners

Recruiting

Minneapolis, Minnesota, United States, 55425

Kaiser Permanente Northwest

Recruiting

Portland, Oregon, United States, 97086

Sanford Health

Recruiting

Sioux Falls, South Dakota, United States, 57117

Baylor Scott and White Health

Recruiting

Dallas, Texas, United States, 75246

Marshfield Clinic Health System

Recruiting

Marshfield, Wisconsin, United States, 54449

More Information

Sponsor

National Cancer Institute (NCI)

Last update posted

Aug 28, 2026

Last verified

Aug 18, 2026

Keywords

  • Risk Factors
  • medical conditions
  • Pathology
  • Blood
  • Urine
  • Natural History

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by National Cancer Institute (NCI) on 2026-08-28.