Recruiting

Observational Study

Sponsor:

University of Manitoba

Code:

NCT04621396

Conditions

Type 2 Diabetes

Gestational Diabetes Mellitus

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Accepted

Interventions

Observational screening study

Study Details

Brief summary:

The overall aim of this project is to understand the independent roles of maternal factors, intrauterine exposures, genetic factors, and postnatal environment on the development of obesity and youth-onset type 2 diabetes (T2D) in childhood.

Conditions

Type 2 Diabetes

Gestational Diabetes Mellitus

Study ID

NCT04621396

Start date

Sep, 2013

Status verified date

Jun, 2026

Completion date

Dec, 2028

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Pregnant women with type 2 diabetes, gestational diabetes, or no diabetes.
  • From self-identified Indigenous heritage (e.g., Cree, Oji-Cree, Métis, Anishinaabe, etc.).
  • Are delivering and residing in Manitoba.
  • Mother/Father and children must be biological family members.

Exclusion Criteria:

  • Mothers or children with type 1 diabetes.
  • Residing outside of Manitoba.

Study Design

Enrollment

600 participants

Anticipated

Interventions and Outcome Measures

Arms

Next Generation Cohort

We will follow the children from mothers who either have T2D, GDM, or are controls.

Interventions

Observational screening study

Primary outcome measure

  • Obesity [ Time Frame: 18 years ]
  • Type 2 Diabetes [ Time Frame: 18 years ]

Central Contacts and Locations

Central contacts

Brandy A Wicklow, MD, MSc

204-787-1222bwicklow@hsc.mb.ca

Elizabeth AC Sellers, MD, MSc

204-787-3011esellers@hsc.mb.ca

Locations

Children's Hospital Research Institute of Manitoba/University of Manitoba

Recruiting

Winnipeg, Manitoba, Canada, R3E 3P4

Contacts

Brandy A Wicklow, MD, MSc

204781222bwicklow@hsc.mb.ca

More Information

Sponsor

University of Manitoba

Last update posted

Jul 2, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Manitoba on 2026-07-02.