Recruiting

Observational Study

Sponsor:

University of British Columbia

Code:

NCT04702945

Conditions

Covid-19

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Coronavirus Disease 2019 (COVID -19) is the largest public health crisis in over a century. There is an urgent need for high-quality population-level data to understand modifiable risks for disease severity, transmissibility, and to develop evidence-based prevention (i.e. vaccination), treatment and resource allocation strategies.

The Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) created a population-based registry of suspected and confirmed consecutive cases of COVID-19. The purpose of this registry is to derive and validate clinical decision rules, evaluate diagnostic tests and vaccine effectiveness, and complete cohort, case-control and observational studies to inform the pandemic response.

Conditions

Covid-19

Study ID

NCT04702945

Start date

Mar 1, 2020

Status verified date

Jan, 2021

Completion date

Dec 31, 2023

Anticipated

Primary completion date

Dec 31, 2022

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

The investigators defined two periods for enrollment based on the availability of COVID-19 testing. Research assistants used medical microbiology testing and discharge diagnoses to screen for potentially eligible patients.

In Period 1, COVID-19 testing in each province was restricted to specific patient populations (e.g., healthcare workers, admitted patients).

Inclusion Criteria:

  • Meeting the WHO suspect COVID-19 criteria: Fever (self-reported or subjective fever) and at least one symptom/sign of respiratory illness (e.g., flu-like illness, cough, shortness of breath)
  • Presenting to the emergency department and tested for COVID-19 in the emergency department

No exclusion criteria in Period 1

Period 2 started on the date which each province expanded testing criteria allowing clinicians to test patients based on clinical suspicion or policy.

Inclusion Criteria:

  • Presenting to the emergency department within 14 days of a positive COVID-19 (by self-report or in medical chart) and presents with clinical symptoms consistent with COVID-19
  • Tested for COVID-19 in the emergency department, or within 24 hours after emergency department arrival.

Exclusion Criteria

  • Patients tested for COVID-19 in the context of an elective admission (e.g., planned hip revision)
  • Patients tested for COVID-19 and seen in the emergency department directly by another service (e.g., trauma team activation)

Study Design

Enrollment

200000 participants

Anticipated

Interventions and Outcome Measures

Arms

Registry participants

Patients presenting to participating emergency departments with suspected and or confirmed COVID-19.

Primary outcome measure

  • Confirmed COVID-19 diagnosis [ Time Frame: 14 days ]

Central Contacts and Locations

Central contacts

Corinne M Hohl, MD, MSc

604-875-4111corinne.hohl@ubc.ca

Laurie Morrison, MD,MSc

416-864-6060Laurie.Morrison@unityhealth.to

Locations

Foothills Medical Centre

Recruiting

Calgary, Alberta, Canada

Peter Lougheed Centre

Recruiting

Calgary, Alberta, Canada

Rockyview General Hospital

Recruiting

Calgary, Alberta, Canada

South Health Campus

Recruiting

Calgary, Alberta, Canada

Northeast Community Health Centre

Recruiting

Edmonton, Alberta, Canada

Royal Alexandra Hospital

Recruiting

Edmonton, Alberta, Canada

University of Alberta Hospital

Recruiting

Edmonton, Alberta, Canada

Abbotsford Regional Hospital

Recruiting

Abbotsford, British Columbia, Canada

Royal Inland Hospital

Recruiting

Kamloops, British Columbia, Canada

Kelowna General Hospital

Recruiting

Kelowna, British Columbia, Canada

Royal Columbian Hospital

Recruiting

New Westminster, British Columbia, Canada

Lions Gate Hospital

Recruiting

North Vancouver, British Columbia, Canada

Eagle Ridge Hospital

Recruiting

Port Moody, British Columbia, Canada

Surrey Memorial Hospital

Recruiting

Surrey, British Columbia, Canada

Mount Saint Joseph Hospital

Recruiting

Vancouver, British Columbia, Canada

St. Paul's Hospital

Recruiting

Vancouver, British Columbia, Canada

Vancouver General Hospital

Recruiting

Vancouver, British Columbia, Canada

Saint John Regional Hospital

Recruiting

Saint John, New Brunswick, Canada

Dartmouth General Hospital

Recruiting

Dartmouth, Nova Scotia, Canada

Halifax Infirmary

Recruiting

Halifax, Nova Scotia, Canada

Cobequid Community Health Centre

Recruiting

Lower Sackville, Nova Scotia, Canada

Hants Community Hospital

Recruiting

Windsor, Nova Scotia, Canada

Hamilton General Hospital

Recruiting

Hamilton, Ontario, Canada

Juravinski Hospital

Recruiting

Hamilton, Ontario, Canada

Hotel Dieu Hospital

Recruiting

Kingston, Ontario, Canada

Kingston General Hospital

Recruiting

Kingston, Ontario, Canada

London Health Sciences Centre (University Hospital)

Recruiting

London, Ontario, Canada

London Health Sciences Centre (Victoria Hospital)

Recruiting

London, Ontario, Canada

The Ottawa Hospital - Civic Campus

Recruiting

Ottawa, Ontario, Canada

The Ottawa Hospital - General Campus

Recruiting

Ottawa, Ontario, Canada

Health Science North

Recruiting

Sudbury, Ontario, Canada

North York General Hospital

Recruiting

Toronto, Ontario, Canada

Sunnybrook Hospital

Recruiting

Toronto, Ontario, Canada

Toronto Western Hospital

Recruiting

Toronto, Ontario, Canada

Hôtel-Dieu de Lévis

Recruiting

Lévis, Quebec, Canada

Hôpital du Sacré-Coeur

Recruiting

Montréal, Quebec, Canada

Jewish General Hospital

Recruiting

Montréal, Quebec, Canada

Montréal General Hospital (MUHC)

Recruiting

Montréal, Quebec, Canada

Royal Victoria Hospital (MUHC)

Recruiting

Montréal, Quebec, Canada

Centre Hospitalier de l'Université Laval (CHU de Québec)

Recruiting

Québec, Quebec, Canada

Hôpital de l'Enfant-Jésus (CHU de Québec)

Recruiting

Québec, Quebec, Canada

Hôpital du Saint-Sacrement (CHU de Québec)

Recruiting

Québec, Quebec, Canada

Hôpital Saint-François d'Assise (CHU de Québec)

Recruiting

Québec, Quebec, Canada

Hôtel-Dieu de Québec (CHU de Québec)

Recruiting

Québec, Quebec, Canada

Institut universitaire de cardiologie et de pneumologie de Québec

Recruiting

Québec, Quebec, Canada

Pasqua Hospital

Recruiting

Regina, Saskatchewan, Canada

Regina General Hospital

Recruiting

Regina, Saskatchewan, Canada

Royal University

Recruiting

Saskatoon, Saskatchewan, Canada

Saskatoon City Hospital

Recruiting

Saskatoon, Saskatchewan, Canada

St Paul's Hospital

Recruiting

Saskatoon, Saskatchewan, Canada

More Information

Sponsor

University of British Columbia

Last update posted

Jan 11, 2021

Last verified

Jan, 2021

Keywords

  • Coronavirus
  • Infectious diseases
  • Registry

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of British Columbia on 2021-01-11.