Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT04717869

Conditions

Frailty

Sarcopenia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Ultrasound

Biomarker Analysis

Frailty Index

Study Details

Brief summary:

Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential targets to reduce frailty.

Conditions

Frailty

Sarcopenia

Study ID

NCT04717869

Start date

Sep 22, 2023

Status verified date

Jan, 2026

Completion date

Jul, 2026

Anticipated

Primary completion date

May, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU
  • ICU stay longer than 24 hours

Exclusion Criteria:

  • Patients with muscular or mitochondrial diseases affecting muscle quality or mass
  • Preexisting paralysis
  • Absence of lower limbs
  • Ongoing discussions about goals of care
  • Transfers from a skilled nursing facility
  • Children under the age of 18

Study Design

Enrollment

250 participants

Anticipated

Interventions and Outcome Measures

Arms

ICU Patients

Adult Surgical, Cardiothoracic, and Neuro- ICU patients will be enrolled within 48 hrs of admission

Interventions

Ultrasound

2D ultrasound image collection

Biomarker Analysis

Inflammatory and nutritional biomarker analysis

Frailty Index

A Frailty Index Questionnaire be completed by patients or their surrogates to determine the presence of frailty at ICU admission

Primary outcome measure

  • Discharge Disposition [ Time Frame: Patients will be followed from enrollment to hospital discharge. Approximately 2 weeks to 2 months ]
  • Length of ICU stay [ Time Frame: Patients will be followed from enrollment to ICU transfer. Approximately 2 weeks to 2 months ]
  • Length of Hospital stay [ Time Frame: Patients will be followed from enrollment until discharge from the hospital. Approximately 2 weeks to 2 months ]

Central Contacts and Locations

Central contacts

Jennifer Scovotti, MA

3102064484jscovotti@mednet.ucla.edu

Locations

Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine

Recruiting

Los Angeles, California, United States, 90095

Contacts

Jennifer Scovotti, MA

3102064484jscovotti@mednet.ucla.edu

Principal Investigator:

Cecilia Canales, MD, MPH

More Information

Sponsor

University of California, Los Angeles

Last update posted

Jan 30, 2026

Last verified

Jan, 2026

Keywords

  • Frailty
  • Sarcopenia
  • Ultrasound

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2026-01-30.