Recruiting

Observational Study

Sponsor:

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Code:

NCT04721652

Conditions

Chronic Kidney Disease Requiring Chronic Dialysis

Interdialytic Weight Gain

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Interdialytic weight gain determines how much fluid (ultrafiltration) has to be removed during each hemodialysis session. High ultrafiltration volumes stress the organism and lead to a higher risk of death. Thirst is the main driving factor of interdialytic weight gain, and thirst is mainly driven by salt intake, molecules that increase blood tonicity (such as sugar in diabetics) and fluid loss (such as in dehydration and blood loss). It has been speculated that fluid loss during hemodialysis could increase the sense of thirst immediately following dialysis, but this statement requires further evidence.

Conditions

Chronic Kidney Disease Requiring Chronic Dialysis

Interdialytic Weight Gain

Study ID

NCT04721652

Start date

Feb 25, 2021

Status verified date

Apr, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥ 18 years
  • Thrice weekly maintenance hemodialysis
  • Willing and able to provide written informed consent

Exclusion Criteria:

  • Diabetes Mellitus
  • Residual Urinary Volume > 500 ml/day
  • Being able to self-monitor one's body weight and blood pressure

Study Design

Enrollment

20 participants

Anticipated

Interventions and Outcome Measures

Arms

Hemodialysis Patients (nondiabetic)

Nondiabetic adult hemodialysis patients

Primary outcome measure

  • T50%IDWG [ Time Frame: Up to one week ]
  • Cumulative IDWG% curve [ Time Frame: Up to one week ]

Central Contacts and Locations

Central contacts

Christopher W. McIntyre, MD, PhD

+1(519)685-8500cmcint48@uwo.ca

Locations

Adam Linton Unit

Recruiting

London, Ontario, Canada, N6A 5W9

Westmount Kidney Care Centre

Recruiting

London, Ontario, Canada, N6K 1M6

Contacts

Christopher W. McIntyre, MD, PhD

519-685-8500cmcint48@uwo.ca

More Information

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Last update posted

May 4, 2026

Last verified

Apr, 2026

Keywords

  • Hemodialysis
  • Interdialytic Weight Gain
  • Thirst

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's on 2026-05-04.