Recruiting

Liquid Biopsy

Sponsor:

Jonsson Comprehensive Cancer Center

Code:

NCT04742608

Conditions

Thyroid Gland Carcinoma

Thyroid Gland Nodule

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection

Electronic Health Record Review

Study Details

Brief summary:

This study is being done to help researchers learn more about and successfully diagnose cancer using blood samples and tissue samples from surgeries in patients with suspicious thyroid nodules or thyroid cancer. Diagnosing cancer in this way, as opposed to biopsies, may be less invasive to the patient. Analyzing blood and tissues samples may also help researchers to differentiate non-cancerous tumors from thyroid cancer and detect high-risk mutations to guide treatment.

Conditions

Thyroid Gland Carcinoma

Thyroid Gland Nodule

Study ID

NCT04742608

Start date

Feb 21, 2020

Status verified date

Mar, 2026

Completion date

Feb 1, 2027

Anticipated

Primary completion date

Jun 9, 2025

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Aged 18 and older
  • Consented for thyroid surgery for thyroid cancer or indeterminate thyroid nodule

Exclusion Criteria:

  • Patients with concurrent malignancy

Study Design

Enrollment

250 participants

Anticipated

Interventions and Outcome Measures

Arms

Ancillary-correlative (biospecimen collection)

Patients undergo collection of blood samples on the day of surgery following anesthesia but prior to incision and at the first routine blood test following surgery. Patients who undergo remnant ablation after total thyroidectomy with radioactive iodine have an additional blood sample collected. Patients also undergo collection of tissue samples following surgical resection of thyroid nodule or thyroid cancer. Patients' medical records are also reviewed.

Interventions

Biospecimen Collection

Undergo collection of blood and tissue samples

Electronic Health Record Review

Medical charts are reviewed

Primary outcome measure

  • Sensitivity of molecular profile of thyroid-derived extracellular vesicles [ Time Frame: Up to 3 years ]
  • Specificity of molecular profile of thyroid-derived extracellular vesicles [ Time Frame: Up to 3 years ]
  • Negative predictive value of molecular profile of thyroid-derived extracellular vesicles [ Time Frame: Up to 3 years ]
  • Positive predictive value of molecular profile of thyroid-derived extracellular vesicles [ Time Frame: Up to 3 years ]

Central Contacts and Locations

Locations

UCLA / Jonsson Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90095

Contacts

James Wu

303-518-3186jameswu@mednet.ucla.edu

Principal Investigator:

James Wu

More Information

Sponsor

Jonsson Comprehensive Cancer Center

Last update posted

Mar 10, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Jonsson Comprehensive Cancer Center on 2026-03-10.