Recruiting

Prostate Cancer Classification

Sponsor:

Jonsson Comprehensive Cancer Center

Code:

NCT04765150

Conditions

Prostate Carcinoma

Eligibility Criteria

Sex: Male

Age: 18+

Healthy Volunteers: Not accepted

Interventions

3 Tesla Magnetic Resonance Imaging

Electronic Health Record Review

Study Details

Brief summary:

This study evaluates how new magnetic resonance imaging (MRI) and artificial intelligence techniques improve the image quality and quantitative information for future prostate MRI exams in patients with suspicious of confirmed prostate cancer. The MRI and artificial intelligence techniques developed in this study may improve the accuracy in diagnosing prostate cancer in the future using less invasive techniques than what is currently used.

Conditions

Prostate Carcinoma

Study ID

NCT04765150

Start date

Apr 1, 2021

Status verified date

May, 2026

Completion date

Jun 1, 2028

Anticipated

Primary completion date

Jun 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Male

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Male patients 18 years of age and older
  • Clinical suspicion of prostate cancer or biopsy-confirmed prostate cancer
  • Undergone or undergoing multi-parametric 3 T prostate MRI at the University of California at Los Angeles (UCLA)
  • Ability to provide consent

Exclusion Criteria:

  • Contraindications to MRI (e.g., cardiac devices, prosthetic valves, severe claustrophobia)
  • Contraindications to gadolinium contrast-based agents other than the possibility of an allergic reaction to the gadolinium contrast-based agent
  • Prior radiotherapy

Study Design

Enrollment

275 participants

Anticipated

Interventions and Outcome Measures

Arms

Observational (electronic health record review, 3 T MRI)

RETROSPECTIVE: Patients' medical records are reviewed.

PROSPECTIVE: Patients undergo additional 3T MRI imaging over 30 minutes before, during, or after their standard of care 3T MRI for a total of 1.5 hours.

Interventions

3 Tesla Magnetic Resonance Imaging

Undergo 3T MRI

Electronic Health Record Review

Medical charts are reviewed

Primary outcome measure

  • Development of quantitative dynamic contrast (DCE)-enhanced-magnetic resonance imaging (MRI) analysis techniques [ Time Frame: Up to 5 years ]
  • Development of diffusion weighted imaging (DWI) methods that reduce prostate geometric distortion [ Time Frame: Up to 5 years ]
  • Development of multi-class deep learning models [ Time Frame: Up to 5 years ]

Central Contacts and Locations

Central contacts

Nashla Barroso

(310) 794-7952nbarroso@mednet.ucla.edu

Locations

UCLA / Jonsson Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90095

Contacts

Nashla Barroso

310-794-7952nbarroso@mednet.ucla.edu

Principal Investigator:

Kyung H. Sung, PhD

More Information

Sponsor

Jonsson Comprehensive Cancer Center

Last update posted

Jul 7, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Jonsson Comprehensive Cancer Center on 2026-07-07.