Recruiting

Observational Study

Sponsor:

Oregon Health and Science University

Code:

NCT04804124

Conditions

Sleep

Cardiovascular Risk Factor

Eligibility Criteria

Sex: All

Age: 25 - 65

Healthy Volunteers: Accepted

Interventions

Regularized Sleep Schedule

Study Details

Brief summary:

This is a cross-sectional study with an optional intervention that will examine how extreme sleep durations relate to cardiovascular health, physical activity, and sleep quality by studying three groups of participants: short sleepers (≤ 6 hrs), long sleepers (≥ 9 hrs), and average duration sleepers (7-8 hrs). The optional intervention asks participants to maintain an 8-hour per night regular sleep schedule for one week.

Conditions

Sleep

Cardiovascular Risk Factor

Study ID

NCT04804124

Start date

Jun 9, 2021

Status verified date

Jul, 2026

Completion date

Sep 15, 2027

Anticipated

Primary completion date

Sep 15, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 25 - 65

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Men and women ages 25-65y
  • Lean and overweight (BMI 18.5-40 kg/m2)
  • No acute, chronic, or debilitating medical conditions
  • No prescription/non-prescription medications or drugs of abuse
  • Current non-smoker (tobacco and marijuana)
  • Persons who fit all the above criteria and are suitable based on a medical history and health habits questionnaire, and additional sleep and health profiling questionnaires may be eligible to participate.

Exclusion Criteria:

  • Persons with any acute, chronic, or debilitating medical condition except pre-hypertension will be excluded.
  • Persons with any symptoms of acute or active illness (e.g. fever, leukocytosis) will be excluded.
  • Persons with a history of severe psychiatric illness or psychiatric disorders will be excluded.
  • Persons with a history of regular night/or rotating shift work in the past year, or who have traveled more than three time zones during the one month prior to the study will be excluded.
  • Pregnant women, decisionally impaired adults, and prisoners will be excluded.

Study Design

Enrollment

24 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Short Sleepers

Reported nightly sleep time of ≤6 hours

experimental: Long Sleepers

Reported nightly sleep time of ≥9 hours

experimental: Average Duration Sleepers

Reported nightly sleep time of 7-8 hours

Interventions

Regularized Sleep Schedule

Participants may maintain a self-selected 8-hour per night sleep schedule as an optional intervention. Participants from any of the three groups may complete the intervention.

Primary outcome measure

  • Vascular Endothelial Function [ Time Frame: 2 weeks ]
  • Blood pressure [ Time Frame: 2 weeks ]
  • Sleep duration [ Time Frame: 2 weeks ]

Central Contacts and Locations

Central contacts

Nicole Chaudhary, MPH

5034942064burkeni@ohsu.edu

Locations

Oregon Health and Science University

Recruiting

Portland, Oregon, United States, 97239

Contacts

Saurabh S Thosar, PhD

503-494-2064clinphys@ohsu.edu

Principal Investigator:

Saurabh S Thosar, PhD

More Information

Sponsor

Oregon Health and Science University

Last update posted

Aug 4, 2026

Last verified

Jul, 2026

Keywords

  • cardiovascular
  • sleep duration
  • vascular endothelial function

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Oregon Health and Science University on 2026-08-04.