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LIFT Intervention

Sponsor:

Northwestern University

Code:

NCT04836923

Conditions

Frailty

Cirrhosis

Liver Transplant

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

"LIver FrailTy" intervention (LIFT)

Study Details

Brief summary:

Frailty is a significant problem in patients undergoing liver transplant and is associated with poor outcomes and survival. Hence, optimizing physical fitness and counteracting frailty is important. However, many interventions are very resource intensive and therefore not feasible.

In this study, the investigators aim to test the effectiveness of a newly designed intervention to improve frailty in liver transplant candidates. The "LIver FrailTy" intervention (LIFT) will consist of an evaluation by a physical therapist, an individualized home exercise prescription (HEP), exercise tracking using a smart phone application, daily text reminders to exercise and recurrent telephone check-ins.

Conditions

Frailty

Cirrhosis

Liver Transplant

Study ID

NCT04836923

Start date

Oct 1, 2020

Status verified date

Apr, 2026

Completion date

Mar 1, 2024

Primary completion date

Mar 1, 2023

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients with a diagnosis of liver cirrhosis being evaluated for liver transplantation in hepatology/transplant evaluation clinic
  • English-speaking
  • Patients with access to a smart phone (with videoconference capabilities)
  • Vulnerable populations: We will include patients who are cognitively impaired due to hepatic encephalopathy and unable to consent for themselves.

Exclusion Criteria:

  • Patients < 18 years of age
  • Patients who require outpatient physical therapy.
  • Patients without the ability to consent for themselves or through a medical power of attorney.

Study Design

Enrollment

81 participants

Intervention Model

Single group

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: LIFT subgroup

Physical Therapy (PT) evaluation, an individualized home exercise prescription (HEP), daily text message reminders to exercise and weekly telephone check-ins with team members.

Interventions

"LIver FrailTy" intervention (LIFT)

Novel physical therapy intervention to decrease frailty in pre-transplant patients

Primary outcome measure

  • Frailty [ Time Frame: Baseline and final frailty assessment (mean time from baseline to final frailty assessment was 216 (± 157) days) ]
  • Patient-reported Physical Function [ Time Frame: Baseline and final frailty assessment (mean time from baseline to final frailty assessment was 216 (± 157) days) ]
  • Exercise Adherence Rate [ Time Frame: 1 month and 3 months after Enrollment, throughout the follow-up period (mean follow-up time is 259 (±190) days) ]

Central Contacts and Locations

More Information

Sponsor

Northwestern University

Last update posted

May 15, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-30. This information was provided to ClinicalTrials.gov by Northwestern University on 2026-05-15. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.