Recruiting
Early Phase 1

Observational Study

Sponsor:

University of Texas Southwestern Medical Center

Code:

NCT04838678

Conditions

Hypertension

Obesity

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Interventions

Neuropeptide Y

Study Details

Brief summary:

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

Conditions

Hypertension

Obesity

Study ID

NCT04838678

Start date

Jul 18, 2021

Status verified date

Sep, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Control - BMI<30, age 18-55
  • Hypertensive - BMI<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI>30, age 18-55 Obese-hypertensive- BMI>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring

Exclusion Criteria:

All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,

Study Design

Enrollment

100 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Healthy Control

Healthy age matched controls with no history of cardiovascular disease and normal bodyweight

experimental: Hypertensive

Hypertensive adults who are not obese

experimental: Obese

Obese adults who are not hypertensive

experimental: Obese-hypertensive

Obese adults who are being treated for hypertension

Interventions

Neuropeptide Y

intra-arterial infusion of neuropeptide Y

Primary outcome measure

  • Blood flow measured by doppler ultrasound [ Time Frame: Acutely on the day of study ]
  • Muscle sympathetic nervous system activity [ Time Frame: Acutely on the day of study ]

Central Contacts and Locations

Central contacts

Christopher M Hearon, Ph.D.

214-345-4624christopher.hearon@utsouthwestern.edu

Mary Childers

214-345-6459marychilders@texashealth.org

Locations

University of Texas Southwestern Medical Center

Recruiting

Dallas, Texas, United States, 75231

Contacts

CHristopher Hearon

8155405612christopherhearon@texashealth.org

More Information

Sponsor

University of Texas Southwestern Medical Center

Last update posted

Sep 3, 2026

Last verified

Sep, 2026

Keywords

  • NPY

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Texas Southwestern Medical Center on 2026-09-03.