Recruiting

Observational Study

Sponsor:

Weill Medical College of Cornell University

Code:

NCT04852354

Conditions

Central Nervous System Tumor

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The purpose of this study is to improve upon the knowledge currently available about central nervous system (CNS) tumors. We will study the different characteristics of these tumors using tissue samples collected during surgery and post-autopsy. The aim is to create tumor cell lines and models to test how they respond to different drugs. This research will help improve treatment options and identify new targets for therapy.

Conditions

Central Nervous System Tumor

Study ID

NCT04852354

Start date

Jul 22, 2020

Status verified date

Dec, 2025

Completion date

Jul 22, 2029

Anticipated

Primary completion date

Jul 22, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Inclusion Criteria for Tumor patients undergoing neurosurgery (cohort 1)

1. Subject has presented with a suspected/confirmed neoplastic CNS lesion and is undergoing a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be removed.
2. There must be tissue available in excess of that required by neuropathology for diagnostic purposes.
3. Subject of all ages included.
4. Subjects who are pregnant can be included.
5. Subjects who are neonates (0-4 weeks) can be included.

Inclusion Criteria for Non-tumor patients undergoing neurosurgery (cohort 2)

1. Subject is between 4 weeks and 21 years of age and is undergoing a neurosurgical procedure at WCMC.
2. Subject does not have a CNS tumor diagnosis.
3. Subject should not be pregnant at the time of enrollment.

Inclusion Criteria for Autopsy tumor tissue donation (cohort 3)

1. Subject of all ages included
2. Subject has been diagnosed with a neoplastic CNS lesion at the time of passing.
3. Subjects who are pregnant can be included.
4. Subjects who are neonates (0-4 weeks) can be included.

Inclusion Criteria for parent of tumor patients

1. Subject is the biological parent of a patient undergoing/ who underwent a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be/ was removed.
2. Subject is the biological parent of patient enrolled in cohort 1.
3. Subject is not pregnant at the time of enrollment.

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Arms

Cohort 1: Tumor patients undergoing neurosurgery

Samples of tumor tissue, blood, CSF, saliva, skull, and dura will be taken during neurosurgery from tumor patients meeting the inclusion criteria.

Parents of tumor patients

Saliva samples will be taken from parents of tumor patients meeting the inclusion criteria.

Cohort 2: Non-Tumor patients undergoing neurosurgery

Blood and CSF samples will be taken from non-tumor patients meeting the inclusion criteria.

Cohort 3: Autopsy tumor tissue donation

Post-mortem biospecimens such as whole brain, spinal cord, biofluids (e.g., cerebrospinal fluid and blood) and skin biopsy will be collected through autopsy donation from brain tumor patients meeting the inclusion criteria.

Primary outcome measure

  • Evaluating and characterizing the genetic, immunohistochemical, cellular, and molecular profiles of pediatric neoplastic lesions [ Time Frame: Through study completion, average 1-3 years ]

Central Contacts and Locations

Central contacts

Jeffrey Greenfield, M.D.

212-746-2363jpgreenf@med.cornell.edu

Pediatric Neurosurgery

212-746-2363pediatricneurosurgery@med.cornell.edu

Locations

Weill Cornell Medicine

Recruiting

New York, New York, United States, 10021

Contacts

Jeffrey Greenfield, M.D.

212-746-2363jpgreenf@med.cornell.edu

Pediatric Neurosurgery

212-746-2363pediatricneurosurgery@med.cornell.edu

Principal Investigator:

Jeffrey Greenfield, M.D.

More Information

Sponsor

Weill Medical College of Cornell University

Last update posted

Dec 17, 2025

Last verified

Dec, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Weill Medical College of Cornell University on 2025-12-17.