Recruiting

Exercise

Sponsor:

University of North Carolina, Greensboro

Code:

NCT04861818

Conditions

Aerobic Exercise

Cognitive Change

Eligibility Criteria

Sex: All

Age: 18 - 25

Healthy Volunteers: Accepted

Interventions

Moderate-intensity aerobic exercise

Study Details

Brief summary:

Cumulative evidence indicates that a single bout of exercise has beneficial impacts on memory in young adults. From a physiological perspective, acute exercise leads to changes of heart rate variability (HRV), which is associated with memory retrieval process. From a psychological perspective, acute exercise increases the arousal level and thus facilitates cognitive processing including memory storage and retrieval. Such HRV- and/or arousal-based effects of exercise on memory could be differed by the time of day in young adults based on their circadian rhythms of HRV. Moreover, young adults prefer afternoon or evening to morning in their circadian rhythms, demonstrating less wakefulness and lower memory performance in the morning relative to afternoon. Based on the potential psychophysiological mechanisms, exercise could impact young adults' memory differently by the time of day. The investigators aim to 1) determine the extent to which the time of day modulates how moderate-intensity cardiovascular exercise impacts verbal-auditory and visuospatial short- and long-term memory in young adults, and 2) consider potential psychological and physiological markers that may mediate exercise's effects on cognitive performance. As cognitive benefits of exercise might differ by the time of day, it is important to investigate such interaction and make the right recommendations of the timing of exercise for young adults in academic settings.

Conditions

Aerobic Exercise

Cognitive Change

Study ID

NCT04861818

Start date

Jun 21, 2021

Status verified date

Dec, 2024

Completion date

Dec 30, 2025

Anticipated

Primary completion date

Dec 30, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 25

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Between the ages of 18-25.
  • Currently meeting the American College of Sports Medicine's recommended guidelines of activity (at least 90 min/week of moderate and/or vigorous physical activity).
  • Willing to participate for 4 days (2 visits) and refrain from exercise outside of the lab for 4 days (1 day before and the day of two visits).

Exclusion Criteria:

  • Any known history of cardiac, pulmonary, or metabolic disease (e.g. cardiovascular disease, asthma, diabetes).
  • A current musculoskeletal injury, mental illness (e.g., depression, anxiety, or stress disorders), or sleep disorder.

Study Design

Enrollment

80 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Morning group

Participant are assigned to the morning group (7-9am) for 30-min exercise/rest interventions.

experimental: Afternoon group

Participant are assigned to the afternoon group (3-5pm) for 30-min exercise/rest interventions.

Interventions

Moderate-intensity aerobic exercise

Eligible participants will come into the lab on day 1 and 3 at the same time of day (either morning at 7-10am or afternoon at 3-5pm). They will be then randomly assigned for a rest or an exercise session prior to the memory test. For the rest condition, they will be required to sit and relax while watching Planet Earth for 30 minutes on a cycle ergometer. During the exercise session, they will complete a moderate-intensity cardiovascular exercise for 20 minutes following a 5-min warm-up and followed by a 5-min cool-down on a cycle ergometer. They will start the memory test immediately after the rest/exercise session.

Primary outcome measure

  • Verbal episodic memory change [ Time Frame: Immediately after the intervention, the first cognitive test ]
  • Visual episodic memory change [ Time Frame: Immediately after the intervention, the second cognitive test ]
  • Lure discrimination index change [ Time Frame: Immediately after the intervention, the third cognitive test ]
  • Working memory change [ Time Frame: Immediately after the intervention, the fourth cognitive test ]

Central Contacts and Locations

Central contacts

Locations

UNC Greensboro

Recruiting

Greensboro, North Carolina, United States, 27412

Contacts

More Information

Sponsor

University of North Carolina, Greensboro

Last update posted

Dec 17, 2024

Last verified

Dec, 2024

Keywords

  • Aerobic exercise
  • Physical activity
  • Cognition

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of North Carolina, Greensboro on 2024-12-17.